In this paper, we represent $n$-qubits as hypermatrices and consider various applications to quantum entanglement. In particular, we use the higher-order singular value decomposition of hypermatrices to prove that the $\pi$-transpose is an LU invariant. Additionally, through our construction we show that the matrix representation of the combinatorial hyperdeterminant of $2n$-qubits can be expressed as a product of the second Pauli matrix, allowing us to derive a formula for the combinatorial hyperdeterminant of $2n$-qubits in terms of the $n$-tangle.