Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi‐institutional retrospective study

Guida, Michele; Campana, Luca Giovanni; Curatolo, P.; Strippoli, Sabino; Bonadies, A; Grilz, Gretha; Cabula, Carlo; Rotunno, Roberta; Bucher, S.; Solari, Nicola; Santoriello, A; Valpione, Sara; Róssi, Carlo

doi:10.1002/jso.24287

Cited by 30 publications

(11 citation statements)

References 38 publications

(57 reference statements)

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“…First line treatment is radical surgery with at least 3 cm margins and adjuvant radiotherapy since the tumor extends well beyond the limits of the apparent clinical lesion, and multifocality is frequent [ 2 ]. If surgery is contraindicated or visceral metastases have already developed, chemotherapy with paclitaxel and/or doxorubicin may be indicated but provides modest results [ 11 , 12 ]. Electrochemotherapy may be a valid option or serve as neoadjuvant therapy prior to surgical excision [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

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An Ecchymosis with Fulminant Evolution

et al. 2021

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We present the case of an 83-year-old woman who presented with an advanced cutaneous angiosarcoma of the head. The tumor had first appeared as a small ecchymosis on her forehead 3 months before admission. There was an extremely rapid and dramatic evolution, as evidenced by photographic documentation by her relatives. Unfortunately, the delay in access to the healthcare system due to the COVID-19 pandemic lockdown and the fulminant growth were the main determinants for our patient outcome.

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Section: Discussionmentioning

confidence: 99%

“…If surgery is contraindicated or visceral metastases have already developed, chemotherapy with paclitaxel and/or doxorubicin may be indicated but provides modest results [ 11 , 12 ]. Electrochemotherapy may be a valid option or serve as neoadjuvant therapy prior to surgical excision [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

An Ecchymosis with Fulminant Evolution

et al. 2021

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“…Patients who underwent cardiac surgery, radiofrequency ablation (RFA), transarterial chemoembolization (TACE), or who have comorbidities such as diabetes can be treated by ECT [ 60 , 61 ]. Its efficacy is well demonstrated for cutaneous and subcutaneous primary and metastatic melanomas [ 62 ], primary and metastatic basal cell carcinoma [ 63 , 64 ], primary and metastatic squamous cell carcinoma [ 65 , 66 ], keratoacanthoma [ 67 ], ungual warts [ 68 ], Kaposi’s sarcoma [ 3 , 69 ], Merkel cell carcinoma [ 70 ], cutaneous primary and metastatic lesions of breast cancer [ 62 , 71 ], soft tissue sarcoma (STS) [ 72 ], cutaneous B-cell lymphoma [ 73 , 74 ], superficial angiosarcoma [ 75 ], locally advanced and metastatic angiosarcoma [ 76 ], and as palliative therapy for tumor complications [ 77 , 78 , 79 ].…”

Section: Clinical Applications Of Ect In Melanomamentioning

confidence: 99%

Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma

et al. 2021

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Electrochemotherapy (ECT) is an effective bioelectrochemical procedure that uses controlled electrical pulses to facilitate the increase of intracellular concentration of certain substances (electropermeabilization/ reversible electroporation). ECT using antitumor drugs such as bleomycin and cisplatin is a minimally invasive targeted therapy that can be used as an alternative for oncologic patients not eligible for surgery or other standard therapies. Even though ECT is mainly applied as palliative care for metastases, it may also be used for primary tumors that are unresectable due to size and location. Skin neoplasms are the main clinical indication of ECT, the procedure reporting good curative results and high efficiency across all tumor types, including melanoma. In daily practice, there are many cases in which the patient’s quality of life can be significantly improved by a safe procedure such as ECT. Its popularity must be increased because it has a safe profile and minor local adverse reactions. The method can be used by dermatologists, oncologists, and surgeons. The aim of this paper is to review recent literature concerning electrochemotherapy and other clinical applications of electroporation for the targeted therapy of metastatic melanoma.

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“…[3][4][5] Although the use of electrochemotherapy for feline angiosarcoma has not previously been reported, a recent retrospective study in humans described the efficacy of electrochemotherapy with bleomycin in 19 patients with angiosarcoma. 6 Two months after treatment, 12 patients (63 per cent) had responded to electrochemotherapy, with eight patients showing complete response and four showing partial response, suggesting that this protocol could also be beneficial in veterinary patients.…”

Section: Introductionmentioning

confidence: 98%

Multimodal treatment approach in a case of feline ventral abdominal angiosarcoma

Maldonado-Moreno¹,

Clemente-Vicario²,

Gonzalez-Gash³

et al. 2019

Vet Record Case Reports

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A 14-year-old male neutered domestic shorthair cat presented for a recurrent angiosarcoma. Previously, the mass was incompletely resected twice at the referring practice with subsequent dehiscence and recurrence. The lesion was re-excised with dirty margins and the cat was treated with courses of adjunct chemotherapy (doxorubicin and toceranib) until progression of the angiosarcoma was noted four months after surgery. A fourth surgery was performed, resecting the mass en bloc with 2 cm margins and one fascial plane, achieving clean margins. Doxorubicin was resumed postoperatively, but nine weeks later another inguinal mass developed. Electrochemotherapy with intravenous bleomycin was elected as a rescue treatment, which resulted in complete response for three months. One month later, the patient presented with anaemia, tachycardia, tachypnoea and hypothermia. Staging revealed renal and pulmonary nodules. Due to declining quality of life and progressive disease, the owners elected euthanasia, at which time the cat had survived 13 months following initial diagnosis.

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Local treatment with electrochemotherapy of superficial angiosarcomas: Efficacy and safety results from a multi‐institutional retrospective study

Abstract: Electrochemotherapy may represent a new locoregional treatment for selected patients with superficial angiosarcomas. J. Surg. Oncol. 2016;114:246-253. © 2016 Wiley Periodicals, Inc.

Cited by 30 publications

References 38 publications

An Ecchymosis with Fulminant Evolution

An Ecchymosis with Fulminant Evolution

Electrochemotherapy and Other Clinical Applications of Electroporation for the Targeted Therapy of Metastatic Melanoma

Multimodal treatment approach in a case of feline ventral abdominal angiosarcoma

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