Local treatment of abdominal wound reduces tumor implantation

Wu, Justin S.; Pfister, Suzanne M.; Ruiz, Martha B.; Connett, Judith M.; Fleshman, James W.

doi:10.1002/(sici)1096-9098(199809)69:1<9::aid-jso3>3.0.co;2-7

Cited by 20 publications

(8 citation statements)

References 20 publications

(25 reference statements)

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“…Comparing this study with one from 1998 in which tumoricidal chemicals were used to treat the instruments to reduce tumour implantation at the wound sites. This earlier study used hamsters instead of mice but followed a similar model (8).…”

Section: Message For the Clinicmentioning

confidence: 99%

Honey: nutritional and medicinal value

Khan

Abadin

Rauf

2007

International Journal of Clinical Practice

115

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Honey is not only used as nutrition but also used in wound healing and as an alternative treatment for clinical conditions ranging from gastrointestinal tract (GIT) problems to ophthalmic conditions. We did the literature search and found interesting facts about the nutritional and medicinal value of honey. No wonder, it is a good source of nutrition, the results of the studies prove that it also helps in wound healing. On burns, it has an initial soothing and later rapid healing effects. It has been used as wound barrier against tumour implantation in laparoscopic oncological surgery. No infection has been reported from the application of honey to open wounds. It has a potential therapeutic role in the treatment of gingivitis and periodontal disease. Based on these facts, the use of honey in the surgical wards is highly recommended and patients about to undergo surgery should ask their surgeons if they could apply honey to their wounds postoperation.

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Section: Message For the Clinicmentioning

confidence: 99%

Honey: nutritional and medicinal value

Khan

Abadin

Rauf

2007

International Journal of Clinical Practice

115

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“…After the first report 1 concerning trocar site recurrence (TSR), there was concern about the increased incidence of TI associated with laparoscopic oncological surgery. Although numerous experimental studies [2][3][4][5][6][7][8] showed an increased incidence of TSR, clinical trials [9][10][11] didnotconfirmthisfinding.Inanycase, reports of TSR diminished the widespread use of laparoscopy in malignant disease and evoked the concern of TI once more.…”

Section: Discussionmentioning

confidence: 99%

“…20 Contributing to the implantation of tumor cells may be pneumoperitoneum, carbon dioxide, increased abdominal pressure, the desufflation rate of pneumoperitoneum, and a chimney effect of carbon dioxide leakage around the trocars. [2][3][4][5][6][7][8]19 Wu et al 5 demonstrated that local treatment of abdominal wounds with povidone-iodine and silver sulfadiazine reduced TI. However, these agents do not accelerate wound healing, as does honey, and may in fact impair it.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7][8][9][10][11] The mechanism of TSR, which is most likely a form of TI, remains unclear despite numerous studies. [2][3][4][5][6][7][8] Exfoliation of tumor cells due to tumor manipulation may lead to TI. 11,19 Jones et al 3 showed increasing amounts of the deposition of free intraperitoneal viable tumor cells into experimental trocar site wounds as local isolated recurrences.…”

Section: Commentmentioning

confidence: 99%

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Protective Covering of Surgical Wounds With Honey Impedes Tumor Implantation

Hamzaoğlu

Sarıbeyoğlu²,

Durak³

et al. 2000

Arch Surg

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Tumor implantation (TI) development at the surgicalwoundfollowingcancersurgeryisstillanunresolved concern. Trocar site recurrence, which is likely a form of TI, has become one of the most controversial topics and, with thewidespreadacceptanceoflaparoscopicsurgery,hascaused renewed interest in questions about TI. Honey has positive effects on wound healing. Physiological and chemical properties of honey might prevent TI when applied locally. Design, Interventions, and Main Outcome Measures: Sixty BALB/c strain mice, divided into 2 groups, were wounded in the posterior neck area. Group 1 mice formed the control group, and group 2 mice had wounds coated with honey before and after tumor inoculation. All wounds were inoculated with transplantable Ehrlich ascites tumor. The presence of TI was confirmed in the wounded area by histopathological examination on the 10th day. Results: Tumor implantation was achieved in all group 1 animals and verified by palpable mass and histopathological examination. In group 2 mice, although TI could not be detected macroscopically, it was revealed by pathological examination in 8 cases. Tumor implantation was less likely in group 2 mice (8 of 30 vs 30 of 30; PϽ.001).

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“…72 Other studies have focused on the local treatment of trocar wounds such as the application of povidone-iodine solution or silver sulfadiazine prior to pneumoperitoneum with moderate reduction of the tumor cell implantation rate in a hamster model. 112 In another study, the more drastic excision of laparoscopic abdominal wound sites significantly reduced the incidence of tumor cell implantation on wound sites. 113 However, the clinical use of the latter measure is impractical and remains unproved.…”

Section: Experimental Studies On Preventive Measuresmentioning

confidence: 94%

Wound Recurrences Following Laparoscopic-Assisted Colectomy for Cancer

Stocchi

Nelson

2000

Arch Surg

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To determine the incidence and clinical relevance of wound recurrences (WRs) following laparoscopic-assisted colectomy for cancer; to analyze the most recent experimental studies examining possible pathogenic mechanisms; and to delineate possible prevention strategies. Data Sources: A MEDLINE search was conducted using the words "colectomy," "laparoscopy," and "recurrence, local." Additional articles were retrieved by crossreferencing. Study Selection: All clinical and experimental studies retrieved were reviewed and subjectively selected according to their relevance for clinical practice. Data Extraction: Clinical data from 1990 to 2000 with series analyzing 50 or more patients were preferentially considered. Experimental data were considered based on the most rigorous study designs and the potential impact of experimental findings on clinical practice. Data Synthesis: The incidence of WRs in large series and based on current techniques is comparable to what has been reported for WR following open colectomy. While the pathogenesis of early WR occurrences remains unclear, experience and appropriate training in laparoscopic-assisted colectomy are essential to minimize the incidence of WRs. Results from experimental studies are still controversial, and available data from prospective randomized clinical trials are still limited. Conclusions: Results from prospective randomized trials are needed to provide definitive answers regarding the incidence and survival impact of WRs. Until then, WR may be considered a technical complication following laparoscopic-assisted colectomy.

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Local treatment of abdominal wound reduces tumor implantation

Cited by 20 publications

References 20 publications

Honey: nutritional and medicinal value

Honey: nutritional and medicinal value

Protective Covering of Surgical Wounds With Honey Impedes Tumor Implantation

Wound Recurrences Following Laparoscopic-Assisted Colectomy for Cancer

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