Local treatment of a contaminated skin wound using an original drug combination and magnetic therapy in an experiment

Abstract

Currently, treatment of contaminated skin wounds aggravated by ischemia of superficial soft tissues is a problem that presents certain difficulties. The search for the new ways of treatment and drugs possessing a multidirectional effect is a relevant problem. In this study, we aimed to explore the peculiarities of wound evolution and the effectiveness of the designed combination of medicines and magnetic therapy in a contaminated skin wound case. For the experiment, we divided male Wistar rats into 3 groups and modeled a contaminated skin wound in each of the animals. In the first group, no treatment was performed, in the second, we used the developed combination (benzalkonium chloride, dexpanthenol, pentoxifylline and carboxymethylcellulose sodium salt, combined with magnetic therapy), in the third — ointment with dioxomethyltetrahydropyrimidine + chloramphenicol and magnetic therapy. Planimetry, acid-base balance registration, measurements of microhemocirculation and local temperature of the wound bed underpinned monitoring assessment of the wounds. At the end of the study, the wound area in the second group was 10.7 and 3.7 (p < ; 0.05 ) times smaller than in the first and third groups, respectively, and healing rate — 2.6 and 1.3 (p < 0.05 ) times faster. The maximum values of microhemocirculation and the lowest pH were registered in the second group. Thus, combination of drugs and magnetotherapy we designed promoted healing of a contaminated skin wound, which allows recommending this treatment method for further study at the preclinical level.