Local translation in neuronal compartments: how local is local?

Rangaraju, Vidhya; Dieck, Susanne tom; Schuman, Erin M.

doi:10.15252/embr.201744045

Cited by 161 publications

(155 citation statements)

References 217 publications

(344 reference statements)

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“…Growing evidence has suggested that local translation near the stimulated spines occurs, and influences cytoskeletal remodeling during spine morphogenesis (Jung et al, 2014; Rangaraju et al, 2017). We next discuss molecular networks controlling local translation and its implications for spine structural plasticity.…”

Section: Protein Synthesis-dependent Remodeling Of the Spinementioning

confidence: 99%

Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization

Nakahata

Yasuda

2018

Front. Synaptic Neurosci.

177

161

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Dendritic spines are small protrusive structures on dendritic surfaces, and function as postsynaptic compartments for excitatory synapses. Plasticity of spine structure is associated with many forms of long-term neuronal plasticity, learning and memory. Inside these small dendritic compartments, biochemical states and protein-protein interactions are dynamically modulated by synaptic activity, leading to the regulation of protein synthesis and reorganization of cytoskeletal architecture. This in turn causes plasticity of structure and function of the spine. Technical advances in monitoring molecular behaviors in single dendritic spines have revealed that each signaling pathway is differently regulated across multiple spatiotemporal domains. The spatial pattern of signaling activity expands from a single spine to the nearby dendritic area, dendritic branch and the nucleus, regulating different cellular events at each spatial scale. Temporally, biochemical events are typically triggered by short Ca2+ pulses (~10–100 ms). However, these signals can then trigger activation of downstream protein cascades that can last from milliseconds to hours. Recent imaging studies provide many insights into the biochemical processes governing signaling events of molecular assemblies at different spatial localizations. Here, we highlight recent findings of signaling dynamics during synaptic plasticity and discuss their roles in long-term structural plasticity of dendritic spines.

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Section: Protein Synthesis-dependent Remodeling Of the Spinementioning

confidence: 99%

Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization

Nakahata

Yasuda

2018

Front. Synaptic Neurosci.

177

161

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“…In neurons, mRNAs can be trafficked to distant sites in axons and dendrites for local translation and processing [52][53][54][55][56][57]. A range of neuronal transmembrane proteins, including AMPARs, NMDARs and GABA B Rs, can be translated using both somatic and dendritically localised ribosome patterned rough ER.…”

Section: Local Dendritic Translation and Secretory Pathway Traffickingmentioning

confidence: 99%

Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

et al. 2017

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Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

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“…These locally generated proteins contribute to growth and function of axons as well as retrograde signaling for injury responses and survival in the peripheral nervous system (PNS) (2,3). The transport of mRNAs into axons and their translation within axons can be regulated by extracellular stimuli (4).…”

Section: Introductionmentioning

confidence: 99%