Local Tissue Damage in Cows after Intramuscular Administration of Preparations Containing Phenylbutazone, Flunixin, Ketoprofen and Metamizole

Pyörälä, Satu; Laurila, Tapio; Lehtonen, Sanna; Leppä, Sirpa; Kaartinen, Liisa

doi:10.1186/bf03547031

Cited by 32 publications

(6 citation statements)

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“…Intramuscular injections can result in elevated plasma CK concentration due to local muscle trauma at the injection site, 53 and a placebo administered by the same route was included in the study design to control for this. A small study of five animals suggested that, although intramuscular administration of ketoprofen does not appear to be painful, CK concentration following intramuscular ketoprofen administration is elevated for up to 50 hours postinjection compared with CK concentration in cows administered saline, 54 and this may explain the results seen. Larger injection volumes are associated with increased tissue damage, 54 and this may be why a similar effect was not seen in calves in this study.…”

Section: Discussionmentioning

confidence: 95%

“…A small study of five animals suggested that, although intramuscular administration of ketoprofen does not appear to be painful, CK concentration following intramuscular ketoprofen administration is elevated for up to 50 hours postinjection compared with CK concentration in cows administered saline, 54 and this may explain the results seen. Larger injection volumes are associated with increased tissue damage, 54 and this may be why a similar effect was not seen in calves in this study. In calves born to primiparous dams, plasma CK concentration was higher than in those born to multiparous dams.…”

Section: Discussionmentioning

confidence: 95%

See 1 more Smart Citation

Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial

et al. 2018

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Dystocia is considered painful and stressful for both the dam and the calf, although systematic evidence of this is limited. Few studies have investigated biochemical markers of stress and pain postpartum and whether any adverse effects are ameliorated by administration of analgesia. In this study, cow-calf pairs experiencing both mild to moderate farmer assistance and no assistance at parturition were randomly assigned to either treatment or placebo group in a two-by-two design (animals subject to veterinary intervention were excluded). The treatments were the NSAID ketoprofen or saline, administered within three hours of parturition. Blood samples taken in the immediate postpartum period, and at 24 hours, 48 hours and 7 days after parturition, were analysed for plasma concentrations of creatine kinase and cortisol (cows and calves) and plasma L-lactate and total protein concentration (calves). Stress biomarkers were highest in the immediate postpartum period and declined over time (P<0.05). Cow plasma cortisol was higher in animals experiencing assisted parturition in the immediate postpartum period (P=0.023); by 24 hours no difference was evident. Intervention with NSAID analgesia did not result in beneficial changes in stress biomarkers. Based on biomarkers alone, this suggests limited benefits of NSAID treatment in unassisted or mild to moderately assisted parturition.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 95%

Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial

et al. 2018

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“…The extra-label administration of flunixin via intramuscular (i.m.) route has been associated with myonecrosis and damage to muscle tissue in cattle (Pyörälä et al, 1999;Smith et al, 2008). Consequently, a subcutaneous (s.c.) route of administration may be more practical than i.v.…”

Section: Introductionmentioning

confidence: 99%

Effect of preemptive flunixin meglumine and lidocaine on behavioral and physiological indicators of pain post-band and knife castration in 6-mo-old beef calves

et al. 2019

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One hundred and seventy-four Angus bull calves (248 ± 27.1 kg of body weight (BW), 6-mo-old) were used in a 71 d study to assess the efficacy of the combination of flunixin meglumine and lidocaine in mitigating pain associated with band and knife castration. The experiment consisted of a 3 × 2 factorial design that included castration method -sham (C), band (B) or knife (K); and medicationlidocaine (scrotal ring block 30 mL, 2% HCl lidocaine) and flunixin meglumine (single s.c. dose of 2.2 mg/kg BW) (M), or saline solution (NM). Animals were weighed on d 0 and weekly until d 71 (final BW) post-castration to obtain ADG. Physiological indicators included salivary cortisol collected on d 0 (30, 60, 120 and 240 min), d 2, 8, and weekly until d 48 postcastration; scrotal and eye temperature assessed on d 1, 2, 6, 8, and weekly until d 36 postcastration; fecal samples for E. coli collected on d 0, 2, 6, 8, and 22 post-castration. Behavioral measures included stride length on d 0, 8, and weekly until d 36, visual analog scale (VAS) evaluated during castration, and feeding behavior collected daily from d 0 to d 71 post-castration.Final BW and ADG were greater (P < 0.05) in C than B and K castrated calves. Salivary cortisol concentrations were greater (P < 0.05) in B and K calves than C calves up to 4-h post-castration, and remained greater in K calves up to 48-h post-castration, while concentrations were lower (P = 0.01) in M than NM calves. Fecal E. coli varied daily (P = 0.01) however, no obvious pattern over time. Scrotal temperature was greatest (P < 0.05) in K, intermediate in C and lowest in B calves, except at 30 min, and 22 and 36 d post-castration where they did not differ from C calves. Eye temperature was greater (P < 0.05) in B and K than C calves on d 2 and 8 post-castration. No differences (P > 0.10) were observed for stride length. The VAS scores were greater (P = 0.01) in K than C and B calves, while NM had greater scores (P < 0.01) than M calves. Dry matter intake and meal size were greater (P = 0.05) in M than NM calves. Meal duration was greater (P = 0.01) in B and C than K calves on d 0, while K calves had greater (P < 0.01) meal duration than C calves 3 1 and 2-wk post-castration. Overall, the combination of flunixin meglumine and lidocaine reduced physiological and behavioral indicators of pain, suggesting that their combined use was effective at mitigating pain associated with band and knife castration.

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“…The flunixin meglumine administration following the recommended dose (1.1 to 2.2 mg/kg) and route (IV) in cattle has WPs of 36 hours and four days for milk and meat. Flunixin meglumine is highly irritating when injected IM [137]. It was also associated with the vehicle propylene glycol used in the formulation, known to be irritating to muscle tissue [138].…”

Section: Drug Treatment-related Factorsmentioning

confidence: 99%

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

Cantón

Lanusse

Moreno

2021

Animals

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Drugs are used in veterinary medicine to prevent or treat animal diseases. When rationally administered to livestock following Good Veterinary Practices (GVP), they greatly contribute to improving the production of food of animal origin. Since humans can be exposed chronically to veterinary drugs through the diet, residues in food are evaluated for effects following chronic exposures. Parameters such as an acceptable daily intake (ADI), the no-observed-adverse-effect level (NOAEL), maximum residue limits (MRLs), and the withdrawal periods (WPs) are determined for each drug used in livestock. Drug residues in food exceeding the MRLs usually appear when failing the GVP application. Different factors related either to the treated animal or to the type of drug administration, and even the type of cooking can affect the level of residues in edible tissues. Residues above the MRLs can have a diverse negative impact, mainly on the consumer’s health, and favor antimicrobial resistance (AMR). Drug residue monitoring programmes are crucial to ensure that prohibited or authorized substances do not exceed MRLs. This comprehensive review article addresses different aspects of drug residues in edible tissues produced as food for human consumption and provides relevant information contributing to rational pharmacotherapy in food-producing animals.

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Local Tissue Damage in Cows after Intramuscular Administration of Preparations Containing Phenylbutazone, Flunixin, Ketoprofen and Metamizole

Cited by 32 publications

References 10 publications

Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial

Postpartum ketoprofen treatment does not alter stress biomarkers in cows and calves experiencing assisted and unassisted parturition: a randomised controlled trial

Effect of preemptive flunixin meglumine and lidocaine on behavioral and physiological indicators of pain post-band and knife castration in 6-mo-old beef calves

Rational Pharmacotherapy in Infectious Diseases: Issues Related to Drug Residues in Edible Animal Tissues

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