Local tissue and blood eosinophils in newborn infants

Matheson, A.; Rosenblum, Arthur H.; Glazer, Richard; Dacanay, Eleonora

doi:10.1016/s0022-3476(57)80067-5

Cited by 30 publications

(12 citation statements)

References 8 publications

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“…1). These values are well within the reported normal range for infants and children in this age group (16,17,19). The difference between these two groups was not statistically significant.…”

Section: Peripheral Blood Eosinophil Counts In Controlssupporting

confidence: 87%

“…These include age and the degree of reduction of peripheral blood eosinophilia related to infection itself. Infected infants less than two months of age were studied separately because infants of this age have been reported to have higher circulating eosinophil counts than older infants (16,17). In the present study, infected infants less than 2 months of age had higher eosinophil counts than older infected infants.…”

Section: Discussionmentioning

confidence: 53%

“…Because previous studies have suggested that eosinophil counts in nasal mucosa (15)(16)(17) and peripheral blood (16) (17) may be greater in the newborn period than at 2 to 3 months of age, peripheral blood eosinophil counts and ECP content of NPS in infants less than 2 months of age were considered separately. These infants included 9 with URI alone, 4 with pneumonia, and 10 with bronchiolitis.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease

Garofalo

Dorris

Ahlstedt

et al. 1994

Pediatric Allergy Immunology

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Infants and young children with acute viral respiratory illness were studied to determine the association of peripheral blood eosinophil counts and concentrations of eosinophil cationic protein (ECP) in nasopharyngeal secretions with the development and severity of bronchiolitis. Subjects included those with upper respiratory illness (URI) alone, pneumonia or bronchiolitis. Controls consisted of healthy infants, and those hospitalized with non-respiratory illnesses. While peripheral blood eosinophil counts were suppressed in all infected infants greater than two months of age, eosinophil counts in patients with bronchiolitis were significantly greater than in those with URI alone. ECP concentrations were significantly greater among individuals with bronchiolitis than other infected infants. For bronchiolitis cases with detectable peripheral blood eosinophils, eosinophil counts correlated weakly and inversely with oxygen saturations. In contrast, ECP concentrations were strongly inversely correlated with initial oxygen saturation. ECP concentrations were also significantly correlated with peripheral blood eosinophil counts. Viral infections suppress peripheral blood eosinophil counts in infants greater than two months of age, although the effect is somewhat overcome in patients with bronchiolitis. The form and severity of bronchiolitis is much more strongly related to degranulation of eosinophils in the respiratory tract than to peripheral blood eosinophil counts.

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Section: Peripheral Blood Eosinophil Counts In Controlssupporting

confidence: 87%

Section: Discussionmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease

Garofalo

Dorris

Ahlstedt

et al. 1994

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…Possible explanations for the finding of eosinophilic infiltrates in EB include increased peripheral and tissue eosinophilia in neonates, excessive eosinophil chemotactic factors, or nonspecific injury to the skin during early neonatal life . Local tissue eosinophilia can occur in newborns, and one study reported that nasal tissue eosinophilia was present in 30% of newborns . However, this does not explain the presence of eosinophils in adults with EB.…”

Section: Discussionmentioning

confidence: 99%

Dermal eosinophilic infiltrate in junctional epidermolysis bullosa

et al. 2015

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Junctional epidermolysis bullosa (JEB) is a rare genodermatosis characterized by a split in the lamina lucida usually because of mutations in LAMA3, LAMB3 and LAMC2 resulting in absence or reduction of laminin-332. Rare subtypes of JEB have mutations in COL17A1, ITGB4, ITGA6 and ITGA3 leading to reduction or dysfunction of collagen XVII, integrin α6β4 and integrin α3. The classic finding under light microscopy is a paucicellular, subepidermal split. We describe the unusual presence of an eosinophilic infiltrate in the bullae and subjacent dermis in a neonate with JEB, generalized intermediate (formerly known as non-Herlitz-type JEB), discuss the histologic differential diagnosis for a subepidermal blister in a neonate, review the literature regarding cases of epidermolysis bullosa (EB) presenting with inflammatory infiltrates, and discuss mechanisms to explain these findings. This case highlights that eosinophils can rarely be seen in EB and should not mislead the dermatopathologist into diagnosing an autoimmune blistering disorder.

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“…Tissue eosinophilia in EB could also be explained as transient neonatal tissue eosinophilia, which is present in about 30% of newborns ( 11), eosinophilic chemotactic properties of protease present in the blister fluid of EB ( 12, 13) or chemotactic substances secreted by mast cells ( 6, 14).…”

Section: Discussionmentioning

confidence: 99%