Local T cell subsets in mumps meningitis.

Nagai, Hiromi; Morishima, Tsuneo; Morishima, Yasuo; Isomura, Shin; Suzuki, Shiori

doi:10.1136/adc.58.11.927

Cited by 14 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in agreement with the data reported by others [ 12,14,15] and similar to the findings in patients with multiple sclerosis [10,20].…”

Section: Discussionsupporting

confidence: 83%

“…As regards acute inflammation of the CNS, only few monoclonal studies of mononuclear cell subsets were published so far [1,12,14,15] Pan-T cells were found to be between 49 and 76% in PB and ranged from 66 to 95% in CSF, showing always higher CSF values. In cases with mumps meningitis and rubella and measles enceph alitis, there was a high percentage of suppressor/cytotoxic cells in CSF, leading to a very low OKT4/OKT8 ratio from 0.31 to 0.74% in this compartment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Bamborschke

Wullen²,

Beil³

1990

Eur Neurol

View full text Add to dashboard Cite

Mononuclear cell subsets in cerebrospinal fluid (CSF) and peripheral blood (PB) were monitored during the clinical course in 23 patients with acute meningitis using 6 monoclonal antibodies. Significant differences between aseptic and bacterial meningitis mainly consisted of a higher percentage of OKT4-positive cells in PB in the acute phase of bacterial meningitis. Significant differences between CSF and PB are found in the amount of most cell subtypes at all times except the acute phase of bacterial meningitis. The OKT4/OKT8 ratio was always significantly higher in CSF and correlated with the acuity of inflammation in bacterial meningitis.

show abstract

“…This is in agreement with the data reported by others [ 12,14,15] and similar to the findings in patients with multiple sclerosis [10,20].…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Bamborschke

Wullen²,

Beil³

1990

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…Besides, in enteroviral meningitis, neutralizing antibody is scarcely found in the cerebrospinal fluid (24). Since the predominant subsets ofT cells in enteroviral and mumps viral meningitis are CD4+ (29) and CD8+ (25,26), respectively, PMNL may also contribute to the subsequent CD4+ T cell infiltration in enteroviral meningitis. PMNL may be thus important as the first line of host defence in enteroviral meningitis.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, in enteroviral meningitis, neutralizing antibody is scarcely found in the cerebrospinal fluid (24). In contrast, both cytotoxic T cells and specific antibodies are detected in mumps viral meningitis (25)(26)(27). PMNL may be thus important as the first line of host defence in enteroviral meningitis.…”

Section: Discussionmentioning

confidence: 99%

Relationship of interleukin‐8 and colony‐stimulating factors to neutrophil migration in aseptic meningitis

et al. 1996

View full text Add to dashboard Cite

Polymorphonuclear neutrophilic leucocyte (PMNL) migration into the subarachnoid space in aseptic meningitis of probable enteroviral aetiology was evaluated in relation to cerebrospinal fluid and serum levels of interleukin-8 (IL-8), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). IL-8 levels reached a plateau within 12h of onset, while M-CSF and G-CSF levels reached a peak between 12 and 24 h after onset, corresponding to the peak increase in PMNL count. G-CSF levels had the closest correlation with PMNL count. M-CSF levels were weakly correlated with PMNL count. IL-8 levels were not correlated with PMNL count except within 12 h of onset. IL-8 and G-CSF were detected predominantly in cerebrospinal fluid, while the M-CSF levels in the two compartments were not different except between 12 and 24 h after onset. It is considered that IL-8 triggers rapid and transient migration of PMNL, and that G-CSF then promotes gradual and consistent infiltration of PMNL.

show abstract

“…Therefore, I developed an ecotoxicity database for paddy pesticides used mainly in Japan. 22) The reliability of the information is categorized into four classes according to the Organization for Economic Cooperation and Development (OECD) Manual for the Assessment of Chemicals: 1=reliable without restrictions, 2=reliable with restrictions, 3=not reliable, and 4=not assignable. The reliability of data in original papers in scientific journals was evaluated according to the method proposed by Hobbs et al 23) In their method, the quality of data presented in published research papers is assessed by awarding scores based on a series of criteria or questions designed to ascertain the scientific rigor of the testing.…”

Section: Development Of An Ecotoxicity Databasementioning

confidence: 99%

Studies on ecological risk assessment of pesticide using species sensitivity distribution

Nagai

2017

J. Pestic. Sci.

View full text Add to dashboard Cite

Species sensitivity distribution (SSD) is a key concept of probabilistic analysis for quantifying ecological risk. I developed a method of probabilistic ecological risk assessment in Japan with a case study of the herbicide simetryn. Then, risk comparison among eleven herbicides was conducted using the developed method. However, one of the most important limitations of SSD application is the lack of sufficient toxicity data for SSD analysis. Thus, an ecotoxicity database was developed for the application of SSD to a wide range of pesticides. After that, I proposed that species batteries of the five species should be the standardized dataset for the SSD analysis of insecticides and herbicides. Finally, I have published a technical guidance document for SSD analysis written in Japanese to promote the application of SSDs in Japan. The remarkable point is that the supplemental Excel-based tool makes it easy to analyze SSDs and conduct ecological risk assessments.

show abstract

Local T cell subsets in mumps meningitis.

Cited by 14 publications

References 5 publications

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Quantitation of Lymphocyte Subsets in Cerebrospinal Fluid and Blood during the Clinical Course of Aseptic and Bacterial Meningitis

Relationship of interleukin‐8 and colony‐stimulating factors to neutrophil migration in aseptic meningitis

Studies on ecological risk assessment of pesticide using species sensitivity distribution

Contact Info

Product

Resources

About