Local surgical excision versus endoscopic resection for rectal carcinoid: A meta-analysis.

Sui, Qiaoqi; Lin, Junzhong; Peng, Jianhong; Zhao, Yujie; Deng, Yuxiang; Pan, Zhizhong

doi:10.7150/jca.21476

Cited by 6 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, those between 10 and 20 mm in size remain controversial. Recent studies have shown oncological safety comparable to that of local surgical excision for lesions 20 mm or smaller in diameter without adverse features and treated with ER (20). In the present study, 80.9% of the tumors were less than 10 mm in size, whereas 19.1% of the tumors larger than 10 mm.…”

Section: Discussionsupporting

confidence: 59%

Efficacy and safety of hybrid endoscopic submucosal dissection compared with endoscopic submucosal dissection for rectal neuroendocrine tumors and risk factors associated with incomplete endoscopic resection

Wang¹,

Chai²,

Linghu³

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

Background: Neuroendocrine tumors (NETs) are rising in prevalence, particularly with the rectal area.This study evaluated and compared the safety and effectiveness of hybrid endoscopic submucosal dissection (ESD) with those of ESD for rectal NETs and risk factors associated with incomplete endoscopic resection.Methods: A total of 272 consecutive patients who underwent ESD or hybrid ESD for rectal NETs at the Chinese PLA General Hospital in the period from February 2011 to September 2018 were involved in this study. Data were collected from clinical and endoscopic databases. The procedure time, en bloc resection, complete resection, complication, and recurrence rates were evaluated.Results: In the hybrid ESD group were 111 patients (who had 119 lesions between them), with a further 161 patients (164 lesions) in the ESD group. No significance was found in baseline characteristics between the two groups. Hybrid ESD had a significantly shorter mean procedure time than ESD (13.2±8.3 vs. 18.1±9.7 min, P=0.000). Hybrid ESD showed similar en bloc resection (99.2% vs. 98.2%; P=0.373), complete resection (94.1% vs. 90.9%, P=0.641), and postprocedural bleeding (2.5% vs. 0.6%, P=0.313) rates to ESD. Univariate and multivariate analysis showed that higher histopathological grade was associated with incomplete resection.Conclusions: For rectal NET, both ESD and hybrid ESD are effective and safe forms of treatment.Hybrid ESD provides an alternative option in the treatment of rectal NETs. Further developments are needed to improve the complete resection rate, especially concerning tumors with higher histopathological grade.

show abstract

Section: Discussionsupporting

confidence: 59%

Efficacy and safety of hybrid endoscopic submucosal dissection compared with endoscopic submucosal dissection for rectal neuroendocrine tumors and risk factors associated with incomplete endoscopic resection

Wang¹,

Chai²,

Linghu³

et al. 2020

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…In traditional cognition, surgery is the best treatment for carcinoids, and the surgical method is selected according to the size of the carcinoid, depth of invasion, and lymph node metastasis [6,7]. At the same time, studies have shown that endoscopic treatment can have a better effect on carcinoids that measure less than 2 cm in diameter [8][9][10]. Small-probe endoscopic ultrasonography (EUS) is becoming increasingly widely used in endoscopy because of its simple operation and because it can provide references for the size, origin level, depth of invasion, surrounding lymph nodes, and blood vessels of the lesion, thus further guiding the resection of submucosal lesions [11,12].…”

Section: Introductionmentioning

confidence: 99%

Application of small-probe endoscopic ultrasonography combined with precut endoscopic mucosal resection in the treatment of rectal carcinoids

ZHANG

Bian

2022

Preprint

View full text Add to dashboard Cite

Purpose: We sought to explore the application value of small-probe endoscopic ultrasonography (EUS) in combination with precut endoscopic mucosal resection (EMR) in the treatment of rectal carcinoids. Methods: Biopsies were performed on patients with rectal submucosal swelling found by colonoscopy at our hospital, and patients whose pathological results were considered indicative of a neuroendocrine tumor were evaluated further. After EUS and computed tomography examinations, patients without peripheral disease or metastasis were treated with precut EMR. Results: Thirty-eight patients were considered to have neuroendocrine tumors by pathological biopsy; of these, 37 patients were treated with precut EMR, and one patient with muscularis propria involvement was treated with surgery. The precut EMR operation time was 28 ± 12 minutes, the whole resection rate was 96.6%, and the complete resection rate was 100%. There were no cases of intraoperative perforation, all of which were located in the rectum. The lesion diameter range was 0.6 to 2.0 cm. There were 10 cases of immediate bleeding during the operation and one case of delayed bleeding after the operation. The length of postoperative follow-up was three to 12 months without recurrence or metastasis. Conclusion: Small-probe ultrasound endoscopy can clarify the depth and diameter of rectal carcinoid invasion, demonstrating a high guiding value for the selection of treatment methods. Precut EMR is a safe, time-saving, and effective method for treating rectal neuroendocrine tumors less than 20 mm in diameter.

show abstract

“…Endoscopic appearance is a kind of information which can be easily assessed and available in most of the patients. Studies about endoscopy for rectal NET are actually not rare but most of them mainly focused on investigating the complete excision rates of different endoscopic or local resection methods [5][6][7]. Few studies investigated the capability of endoscopic appearance of rectal NET to evaluate its malignant behavior.…”

Section: Introductionmentioning

confidence: 99%

Development of a novel scoring system based on endoscopic appearance for management of rectal neuroendocrine tumors

et al. 2020

View full text Add to dashboard Cite

Background and study aims: The clinical significance of endoscopic appearance of rectal neuroendocrine tumor (NET) was poorly understood. We aimed to develop a novel scoring system based on endoscopic appearances to predict endoscopically advanced disease of patients with rectal NET when initially diagnosed. Patients and methods: Patients diagnosed as well-differentiated rectal NET between January 2005 and December 2019 were retrospectively included. Logistic regression analyses were applied to study the relationship between endoscopic appearance and advanced disease. The whole dataset was randomly divided into training set and validating set, and were used to develop and validate a novel scoring system respectively. Results: In total, 309 patients were included. Endoscopic appearance of rectal NET was significantly associated with advanced disease (P<0.001). A novel scoring system was developed based on endoscopic appearance including tumor size, tumor shape and mucosal surface using training set. The area under curve (AUC) of the scoring system to predict advanced disease was 0.953 (95%CI, 0.915-0.991; P<0.001) and 0.960 (95%CI, 0.905-1.000; P<0.001) in training set and validating set respectively. Furthermore, the scoring system was significantly associated with tumor grade. Patients with high score had significantly worse DFS and OS than patients with low score based on the novel scoring system (P<0.001). Conclusion: The proposed novel scoring system based on endoscopic appearance of primary tumor can help accurately identify patients with endoscopically advanced disease who are not suitable for endoscopic resection. In addition, it is of great value in monitoring tumor recurrence and overall survival of patients with rectal NET.

show abstract

Local surgical excision versus endoscopic resection for rectal carcinoid: A meta-analysis.

Cited by 6 publications

References 29 publications

Efficacy and safety of hybrid endoscopic submucosal dissection compared with endoscopic submucosal dissection for rectal neuroendocrine tumors and risk factors associated with incomplete endoscopic resection

Efficacy and safety of hybrid endoscopic submucosal dissection compared with endoscopic submucosal dissection for rectal neuroendocrine tumors and risk factors associated with incomplete endoscopic resection

Application of small-probe endoscopic ultrasonography combined with precut endoscopic mucosal resection in the treatment of rectal carcinoids

Development of a novel scoring system based on endoscopic appearance for management of rectal neuroendocrine tumors

Contact Info

Product

Resources

About