Local structural connectivity is associated with social cognition in autism spectrum disorder

d’Albis, Marc-Antoine; Guevara, Pamela; Guevara, Miguel; Laidi, Charles; Boisgontier, Jennifer; Sarrazin, Sophie; Duclap, Delphine; Delorme, Richard; Bolognani, Federico; Czech, Christian; Bouquet, Céline; Moal, Myriam Ly‐Le; Holiga, Štefan; Amestoy, Anouck; Scheid, Isabelle; Gaman, Alexandru; Leboyer, Marion; Poupon, Cyril; Mangin, Jean‐François; Houenou, Josselin

doi:10.1093/brain/awy275

Cited by 60 publications

(31 citation statements)

References 39 publications

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“…By contrast, our data demonstrate a prolonged MMN latency in response to tonefrequency deviants in the whole ASD group, as reported in AS individuals. As is known, previous research also suggests a key role of the brain temporal regions in either processing language and social cognition abilities (60)(61)(62) or auditory memory processes in ASD individuals (63). Taking these results that refer to available studies together, our findings yield the knowledge that ASD individuals present a significant impairment in pre-attentive temporal auditory processing (64), showing a slower response in the sound duration identification task (65).…”

Section: Discussionsupporting

confidence: 77%

Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

et al. 2020

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The present study investigates the differences in auditory mismatch negativity (MMN) parameters given in a sample of young subjects with autism spectrum disorder (ASD, n = 37) with or without co-occurrent attenuated psychosis syndrome (APS). Our results show that ASD individuals present an MMN decreased amplitude and prolonged latency, without being influenced by concurrent APS. Additionally, when correlating the MMN indexes to clinical features, in the ASD + APS group, we found a negative correlation between the severity of autistic symptoms and the MMN latency in both frequency (f-MMN r = −0.810; p < 0.0001) and duration (d-MMN r = −0.650; p = 0.006) deviants. Thus, our results may provide a more informative characterization of the ASD sub-phenotype when associated with APS, highlighting the need for further longitudinal investigations.

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Section: Discussionsupporting

confidence: 77%

Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

et al. 2020

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“…Systems neuroscience has recently gained unprecedented opportunities to interrogate the human brain at multiple scales in both health and disease 4,6,8,9,18 . Although a wealth of studies in autism spectrum conditions have examined local disturbances in cortical morphology 12,19 and functional connectivity 6,10,14,20,21 as well as mesoscale functional miswiring [22][23][24][25] , less is known about macroscopic changes in structural connectivity [26][27][28][29] . Previous studies observed atypical diffusivity parameters and streamline connections in local brain regions and pathways in autism 27,28 .…”

Section: Introductionmentioning

confidence: 99%

“…Although a wealth of studies in autism spectrum conditions have examined local disturbances in cortical morphology 12,19 and functional connectivity 6,10,14,20,21 as well as mesoscale functional miswiring [22][23][24][25] , less is known about macroscopic changes in structural connectivity [26][27][28][29] . Previous studies observed atypical diffusivity parameters and streamline connections in local brain regions and pathways in autism 27,28 . Such information can be inferred via diffusion magnetic resonance imaging (dMRI) and tractographic algorithms that reconstruct structural wiring [30][31][32][33][34][35] .…”

Section: Introductionmentioning

confidence: 99%

Connectome and microcircuit models implicate atypical subcortico-cortical interactions in autism pathophysiology

Park

Hong

Valk

et al. 2020

Preprint

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Both macroscale connectome miswiring and microcircuit anomalies have been suggested to play a role in the pathophysiology of autism. However, an overarching framework that consolidates these macro and microscale perspectives of the condition is lacking. Here, we combined connectome-wide manifold learning and biophysical simulation models to understand associations between global network perturbations and microcircuit dysfunctions in autism. Our analysis established that autism showed significant differences in structural connectome organization relative to neurotypical controls, with strong effects in low-level somatosensory regions and moderate effects in high-level association cortices. Computational models revealed that the degree of macroscale anomalies was related to atypical increases of subcortical inputs into cortical microcircuits, especially in sensory and motor areas. Transcriptomic decoding and developmental gene enrichment analyses provided biological context and pointed to genes expressed in cortical and thalamic areas during childhood and adolescence. Supervised machine learning showed the macroscale perturbations predicted sociocognitive symptoms and repetitive behaviors. Our analyses provide convergent support that atypical subcortico-cortical interactions may contribute to both microcircuit and macroscale connectome anomalies in autism.

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“…Growing evidence suggests that functional disconnectivity within and across large-scale neural networks is a central hallmark of clinically overlapping neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia (Sharma et al, 2017 ; van den Heuvel et al, 2017 ). Indeed, numerous studies by diffusion tensor imaging (DTI; Cheung et al, 2008 ; Nickel et al, 2017 ; Boets et al, 2018 ; d’Albis et al, 2018 ) and histopathology (Drakesmith et al, 2016 ; Aoki et al, 2017 ) have demonstrated regional deficits in the white matter volume, microstructural alterations in white matter tracts, and aberrant oligodendroglial features in patients with schizophrenia or ASD. Post-mortem microarray and quantitative real-time PCR (qRT-PCR) analysis have revealed a reduction in the expression of oligodendroglia-related genes in multiple brain regions of schizophrenic patients (Tkachev et al, 2003 ; Aberg et al, 2006 ; Sokolov, 2007 ) and children with ASD (Broek et al, 2014 ; Tian et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Poly(I:C) Challenge Alters Brain Expression of Oligodendroglia-Related Genes of Adult Progeny in a Mouse Model of Maternal Immune Activation

Zhang

Chen²,

Yan

et al. 2020

Front. Mol. Neurosci.

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Zhang et al. MIA Alters Oligodendroglia-Related Genes The analysis focused on SOX-10 (SRY-related HMG-box 10), MAG (myelin-associated glycoprotein), and Tf (transferrin) expression in the hippocampus and the surrounding memory-related cortical regions in either hemisphere. Results: Specifically, ISH reveals that in the brain of prenatal poly(I:C)-exposed mouse offspring in the MIA model (gestation day 9), mRNA expression of the genes SOX10, MAG and Tf were generally reduced in the limbic system including the hippocampus, retrosplenial cortex and parahippocampal gyrus on either side of the hemispheres. qRT-PCR further confirms the reduction of SOX10, MAG, and Tf expression in the medial prefrontal cortex, sensory cortex, amygdala, and hippocampus. Conclusions: Our present results provide direct evidence that prenatal exposure to poly(I:C) elicits profound and long-term changes in transcript level and spatial distribution of myelin-related genes in multiple neocortical and limbic regions, notably the hippocampus and its surrounding memory-related neural networks. Our work demonstrates the potential utility of oligodendroglia-related genes as biomarkers for modeling neurodevelopmental disorders, in agreement with the hypothesis that MIA during pregnancy could lead to compromised white matter connectivity in ASD.

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Local structural connectivity is associated with social cognition in autism spectrum disorder

Cited by 60 publications

References 39 publications

Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

Connectome and microcircuit models implicate atypical subcortico-cortical interactions in autism pathophysiology

Poly(I:C) Challenge Alters Brain Expression of Oligodendroglia-Related Genes of Adult Progeny in a Mouse Model of Maternal Immune Activation

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