Local Sleep Taking Care of High-Maintenance Cortical Circuits under Sleep Restriction

Fisher, Simon P.; Vyazovskiy, Vladyslav V.

doi:10.5665/sleep.4156

Cited by 12 publications

(6 citation statements)

References 40 publications

(53 reference statements)

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“…While it is essential to identify mechanisms in order to effectively target interventions, it is also important to recognize that our understanding of sleep function and regulation continues to evolve. For example it has become increasingly clear in recent years that, rather than being a global state, sleep can be considered a localized phenomenon, taking place independently in discrete neural circuits and even individual cells (Fisher and Vyazovskiy, 2014; Nir et al, 2011). Therefore perceptions of inadequate sleep may capture defective sleep processes that we have yet to identify on a physiological level.…”

Section: Discussionmentioning

confidence: 99%

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Sprecher

Bendlin

Racine

et al. 2015

Neurobiology of Aging

192

160

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Midlife may be an ideal window for intervention in Alzheimer’s disease (AD). To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using Positron Emission Tomography (PET) with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale (ESS) and the Medical Outcomes Study (MOS) Sleep Scale in 98 cognitively healthy adults (aged 62.4 ± 5.7 years) from the Wisconsin Registry for Alzheimer’s Prevention. We used multiple regression to test the extent to which sleep scores predicted regional amyloid burden. Participants reporting less adequate sleep, more sleep problems and greater somnolence on the MOS had greater amyloid burden in AD-sensitive brain regions (angular gyrus, frontal medial orbital cortex, cingulate gyrus and precuneus). Amyloid was not associated with reported sleep amount, symptoms of sleep disordered breathing, trouble falling asleep or ESS. Poor sleep may be a risk factor for AD and a potential early marker of AD or target for preventative interventions in mid-life.

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Section: Discussionmentioning

confidence: 99%

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Sprecher

Bendlin

Racine

et al. 2015

Neurobiology of Aging

192

160

View full text Add to dashboard Cite

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“…Neurophysiology of somnolence is still unclear, although acute and chronic daytime sleepiness might be associated with decreasing functional connectivity in the DMN [ 71 ], reflecting a local sleep phase whereby some areas of the brain might be in a sleep state during consciousness [ 72 ]. Other recent studies have shown that the pattern of cerebral activity after acute sleep restriction is highly dependent on level of drowsiness.…”

Section: Discussionmentioning

confidence: 99%

Acute Sleep Deprivation Induces a Local Brain Transfer Information Increase in the Frontal Cortex in a Widespread Decrease Context

Alonso

Romero

Mañanas

et al. 2016

Sensors

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Sleep deprivation (SD) has adverse effects on mental and physical health, affecting the cognitive abilities and emotional states. Specifically, cognitive functions and alertness are known to decrease after SD. The aim of this work was to identify the directional information transfer after SD on scalp EEG signals using transfer entropy (TE). Using a robust methodology based on EEG recordings of 18 volunteers deprived from sleep for 36 h, TE and spectral analysis were performed to characterize EEG data acquired every 2 h. Correlation between connectivity measures and subjective somnolence was assessed. In general, TE showed medium- and long-range significant decreases originated at the occipital areas and directed towards different regions, which could be interpreted as the transfer of predictive information from parieto-occipital activity to the rest of the head. Simultaneously, short-range increases were obtained for the frontal areas, following a consistent and robust time course with significant maps after 20 h of sleep deprivation. Changes during sleep deprivation in brain network were measured effectively by TE, which showed increased local connectivity and diminished global integration. TE is an objective measure that could be used as a potential measure of sleep pressure and somnolence with the additional property of directed relationships.

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“…118 This is a likely consequence of "local sleep" pressure affecting local neural assemblies or high maintenance cortical circuits, and/or deactivation of arousal promoting systems. [119][120][121] In other words, the increased need for sleep at the local level can lead to a breakdown of functions in specific neural areas, as well as a breakdown of connectivity between cortical areas, leading to loss of specific functions or affecting a large number of functions and behaviours. A meta-analysis on seven experimental neuroimaging and sleep manipulation studies showed that sleep deprivation leads to decreased activity in the fronto-parietal attention and salience networks.…”

Section: Circadian Disruptionmentioning

confidence: 99%

Health consequences of shift work and insufficient sleep

Kecklund

Axelsson

2016

BMJ

731

631

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This review summarises the literature on shift work and its relation to insufficient sleep, chronic diseases, and accidents. It is based on 38 meta-analyses and 24 systematic reviews, with additional narrative reviews and articles used for outlining possible mechanisms by which shift work may cause accidents and adverse health. Evidence shows that the effect of shift work on sleep mainly concerns acute sleep loss in connection with night shifts and early morning shifts. A link also exists between shift work and accidents, type 2 diabetes (relative risk range 1.09-1.40), weight gain, coronary heart disease (relative risk 1.23), stroke (relative risk 1.05), and cancer (relative risk range 1.01-1.32), although the original studies showed mixed results. The relations of shift work to cardiometabolic diseases and accidents mimic those with insufficient sleep. Laboratory studies indicate that cardiometabolic stress and cognitive impairments are increased by shift work, as well as by sleep loss. Given that the health and safety consequences of shift work and insufficient sleep are very similar, they are likely to share common mechanisms. However, additional research is needed to determine whether insufficient sleep is a causal pathway for the adverse health effects associated with shift work.

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Local Sleep Taking Care of High-Maintenance Cortical Circuits under Sleep Restriction

Cited by 12 publications

References 40 publications

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults

Acute Sleep Deprivation Induces a Local Brain Transfer Information Increase in the Frontal Cortex in a Widespread Decrease Context

Health consequences of shift work and insufficient sleep

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