Local serotonergic signaling in mammalian follicles, oocytes and early embryos

Dubé, François; Amireault, Pascal

doi:10.1016/j.lfs.2007.09.034

Cited by 78 publications

(70 citation statements)

References 92 publications

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“…Serotonin and 5-HT receptors are found in oocytes, COC, follicular fluid, and embryos in mammals (Dubé & Amireault 2007). The serotonin content in the rat oviduct ranged from 2.06 to 3.34 mg/g fresh tissue (Juorio et al 1989).…”

Section: Discussionmentioning

confidence: 99%

“…In human, serotonin in the preovulatory follicles and the cystically degenerated follicles were 14.3G8.9 and 12.2G6.2 mg/100 ml respectively (Bó dis et al 1992). In the female reproductive organs, serotonin is mainly released from cumulus cells and is associated with the regulation of steroidogenesis and oocyte maturation (Dubé & Amireault 2007). Serotonin at 100 pmol/l induced progesterone released from human granulose cells (Bódis et al 1993).…”

Section: Discussionmentioning

confidence: 99%

“…Because serotonin and 5-HT receptors are found in oocytes, cumulus-oocyte complexes (COC), follicular fluid, and embryos in mammals (Dubé & Amireault 2007), some consider that serotonergic signals are associated with regulation of steroidogenesis, oocyte maturation, and embryonic development. Another study (Meizel & Turner 1983) demonstrated that serotonin and 5-methoxytryptamine, a 5-HT 4 receptor agonist, induce an acrosome reaction (AR) in hamster spermatozoa.…”

Section: Introductionmentioning

confidence: 99%

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Serotonin-enhanced hyperactivation of hamster sperm

Fujinoki¹

2011

Reproduction

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The effects of serotonin on reproductive function were examined using hamster spermatozoa. When serotonin at concentrations from 1 fmol/l to 1 mmol/l was added to modified Tyrode's albumin lactate pyruvate (mTALP) medium, hyperactivation was significantly enhanced. Agonists and antagonists of 5-hydroxytryptamine hydrochloride (5-HT) receptors (5-HT 2 and 5-HT 4 receptors) were added to the medium. Both 5-HT 2 and 5-HT 4 receptor agonists significantly enhanced hyperactivation, although the effect was greater than the former. However, both 5-HT 2 and 5-HT 4 receptor antagonists significantly suppressed serotonin-enhanced hyperactivation, with the former suppressing stimulation by a lower concentration of serotonin than the latter. These results indicate that serotonin enhances hyperactivation via 5-HT 2 and/or 5-HT 4 receptors in a dose-dependent manner.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serotonin-enhanced hyperactivation of hamster sperm

Fujinoki¹

2011

Reproduction

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“…In addition to the raphe, several other tissues produce large amounts of 5-HT by E14, namely the pineal gland, where 5-HT is a precursor of melatonin, and the enterochromaffin and myenteric cells in the gut (Cote et al, 2007). Other tissues, such as the pancreatic beta cells (Paulmann et al, 2009), the parafollicular cells of the thyroid, the ovarian cumulus cells (Dube and Amireault, 2007), the dorsal root ganglia, and the taste buds (Huang et al, 2005) produce smaller amounts of the amine. Collectively, these tissue sources outside of the brain produce $95% of 5-HT.…”

Section: -Ht Sources During Developmentmentioning

confidence: 99%

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

Trowbridge¹,

Narboux-Nême²,

Gaspar³

2010

The Anatomical Record

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A large number of hyposerotonergic genetic models have been generated over the past few years. Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Here we review these various models from a developmental perspective, beginning with a description of the sources of 5-HT during development. We then summarize the neurological and behavioral alterations that have been observed in the genetic hyposerotonergic models. Although these models appear to have normal brain development and do not exhibit any gross morphological defects, problems in somatic growth and physiological functions have been observed. Abnormal adult behavior is also seen, although whether it results from depletion of 5-HT during development or functional 5-HT deficiencies in adult life remains unclear. Evidence from these hyposerotonergic models suggests that the developing brain may not need 5-HT for the establishment of general organization and structure. However, central 5-HT appears to be necessary for postnatal body growth, maturation of respiratory and vegetative control, and possibly for the development of normal adult behavior. Anat Rec, 294:1615Rec, 294: -1623Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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“…At least 15 serotonin receptors, grouped into 7 families due to their signaling mechanisms, have been cloned (20). In mammals, multiple serotonin receptor subtypes are located within the reproductive tract (15). Preimplantation mouse embryos express the serotonin receptors 5-HT1D and 5-HT7 (3,17,44).…”

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confidence: 99%

Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling

Doherty

Kwon

Taylor

2011

American Journal of Physiology-Endocrinology and Metabolism

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Doherty LF, Kwon HE, Taylor HS. Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. Am J Physiol Endocrinol Metab 300: E86-E93, 2011. First published October 19, 2010 doi:10.1152/ajpendo.00439.2010.-Tryptophan 2,3-dioxygenase (TDO) is expressed in endometrium and catabolizes tryptophan, a precursor in the biosynthesis of serotonin. Tryptophan metabolism is an important mechanism for regulation of serotonin levels. Preimplantation mouse embryos are known to express serotonin receptors, specifically the 5-HT1D and 5-HT7 serotonin receptor subtypes. Here we demonstrate that Hoxa10 regulates endometrial TDO expression and improves embryo viability through increased serotonin production. Transfection of pcDNA-Hoxa10 to the murine uterus increased total TDO expression. In vitro, epithelial cell TDO expression was decreased after transfection with Hoxa10. Decreased glandular TDO in response to HOXA10 may augment serotonin production by increasing tryptophan availability. Conversely, stromal TDO expression increased with constitutive Hoxa10 expression. In mice, epithelial serotonin was increased in response to constitutive expression of Hoxa10. Embryo quality was impaired after treatment with Hoxa10 antisense. Blockade of serotonin receptors 1D and 7 also resulted in impaired embryo development, indicating an essential role for Hoxa10 induction of TDO and subsequent serotonin production in embryo development. Transfection of pcDNA-TDO also decreased the number of T cells in the endometrial stroma. We have shown a novel mechanism by which HOXA10 regulates endometrial TDO expression. In the endometrial stroma, HOXA10 increases TDO mRNA, which may increase tryptophan catabolism, allowing for immune tolerance at the time of embryo implantation. In endometrial glands, HOXA10 decreases TDO mRNA leading to increased serotonin that in turn acts to promote normal embryo development. tryptophan degradation; implantation; serotonin THE INDUCTION OF RECEPTIVITY in the mammalian endometrium requires specific molecular and structural alterations in response to hormonal signals. These changes occur within the glandular epithelium and the endometrial stroma to create a favorable environment for embryo implantation. The specific genes responsible for inducing endometrial receptivity, as well as their regulation and function at the time of implantation, remain incompletely characterized.Hoxa10 is a member of the homeobox (Hox) gene family, which encodes transcription factors that function to control embryonic development and to regulate gene expression within the endometrium during the menstrual cycle (39). Hox genes expressed within the reproductive tract regulate normal developmental patterning during the embryonic period and continue to function in the adult. Hoxa10 is expressed by the endometrial glands and stroma throughout the menstrual cycle and its expression is regulated by estradiol and progesterone (36, 38). Mice with targeted disruption of either Hoxa10 or Hoxa11 are infe...

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Local serotonergic signaling in mammalian follicles, oocytes and early embryos

Cited by 78 publications

References 92 publications

Serotonin-enhanced hyperactivation of hamster sperm

Serotonin-enhanced hyperactivation of hamster sperm

Genetic Models of Serotonin (5‐HT) Depletion: What do They Tell Us About the Developmental Role of 5‐HT?

Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling

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