Local resection of benign periampullary tumors

Treitschke, Frank; Beger, H. G.

doi:10.1093/annonc/10.suppl_4.s212

Cited by 34 publications

(21 citation statements)

References 15 publications

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“…Surgical resection of ampullary adenomas is associated with low morbidity and mortality, and ampullary adenocarcinoma is more often resectable and has an increased survival time relative to pancreatic adenocarcinoma (2,5,29). Typical 5-year survival rates for ampullary adenocarcinoma after pancreaticoduodenectomy are around 60%, compared with the dismal 5-year survival rate of around 3.5% for carcinomas of pancreatic ductal origin (29,30).…”

Section: Discussionmentioning

confidence: 99%

“…Ampullary adenoma represents the precursor lesion to adenocarcinoma, and a coexistent adenoma can be identified frequently in patients with ampullary adenocarcinoma (1, 2). Because of their premalignant nature, ampullary adenomas are often resected either by polypectomy or, in the case of larger lesions, by pancreaticoduodenectomy (1,4,5). An association between adenomas of the ampullary region and pancreatic intraductal neoplasia has not been documented previously.…”

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confidence: 99%

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Neoplasms of the Ampulla of Vater with Concurrent Pancreatic Intraductal Neoplasia: A Histological and Molecular Study

et al. 2001

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Adenoma and adenocarcinoma of the ampulla of Vater are uncommon neoplasms of the gastrointestinal tract that are found with increased frequency in familial adenomatous polyposis syndrome (1-3). Ampullary adenoma represents the precursor lesion to adenocarcinoma, and a coexistent adenoma can be identified frequently in patients with ampullary adenocarcinoma (1, 2). Because of their premalignant nature, ampullary adenomas are often resected either by polypectomy or, in the case of larger lesions, by pancreaticoduodenectomy (1,4,5). An association between adenomas of the ampullary region and pancreatic intraductal neoplasia has not been documented previously. Adenocarcinoma of the pancreas is often associated with pancreatic intraductal neoplasia (PanIN), which is thought to represent the precursor lesion for this cancer (6 -12). Several case reports documenting progression of high-grade (HG) PanIN to invasive pancreatic adenocarcinoma over time (17 mo to 29 y) support the role of PanIN as a precursor of carcinoma (10,13,14).The relationship between ampullary adenoma and PanIN has not been investigated previously, and only one analysis of the relationship between

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Neoplasms of the Ampulla of Vater with Concurrent Pancreatic Intraductal Neoplasia: A Histological and Molecular Study

et al. 2001

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“…Villous adenoma should not be diagnosed superficially or else malignant part will be missed (Fenoglio-Preiser CM et al, 1999). Treitschke et al reported that by the evaluation of frozen sections of both ampullary and PC, periampullary frozen tissues shows higher accuracy than ampullary carcinoma (Treitschke F et al, 1999). …”

Section: Tissue Diagnosismentioning

confidence: 99%

Review on Clinical and Molecular Diagnosis of Periampullary carcinoma

2016

Int. J. Adv. Res. Biol. Sci.

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Cancer is one of the predominant diseases and the incidence is largely seen in men when compared to women. Periampullary carcinoma (PC) is an uncommon heterogeneous group of cancer arising from the head region of the pancreas, distal common bile duct and the duodenum. PC can be diagnosed conventionally by clinical and molecular evaluations. Here we evaluate the best way of diagnosis for periampullary carcinoma. Clinical diagnosis deals with the imaging studies including PET (Positron Emission Tomography scan), Computerized Tomography (CT scan), Endoscopic Ultrasonography (EUS), ERCP (Endoscopic Retrograde Cholangiopancreatography) and pathological examination. Molecular examination deals with the evaluation of gene mutation and protein sequences; both the evaluations have their limitation but they have specific application to detect the disease. Comparing with all the imaging and pathological techniques, EUS is the best way to detect cancer because it has the high throughput screening especially in the staging of tumors. Molecular diagnosis is very much focused in the identification of the gene responsible for the carcinoma and it can be achieved by some of the downstream processes such as PCR, RFLP and sequencing.

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“…Adenomas or adenocarcinomas representing > 95% of these lesions [21,22] . AA are benign lesions but, can potencially develop into ampullary carcinomas in a comparable progression to that of colorectal cancer [2,3,[23][24][25][26][27][28][29] .…”

Section: Epidemiologymentioning

confidence: 99%

“…Presenting symptoms are usually non-specific, reflecting biliary or pancreatic obstruction. The most common presentation is with painless jaundice, which is present in 50%-75% of patients [21,[31][32][33][34] . Cholangitis or acute pancreatitis are rare manifestations [35][36][37][38] .…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Endoscopic management of adenomatous ampullary lesions

Espinel¹

2015

WJM

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Lesions of the ampulla of Vater represent an uncommon group of gastrointestinal malignancies. The majority of lesions of the ampulla of Vater are either adenomas or adenocarcinomas. Ampullary lesions are often incidental findings. Accurate preoperative diagnosis and staging of ampullary tumors is imperative for predicting prognosis and determining the most appropriate therapeutic approach. Endoscopic ampullectomy is a safe and efficacious therapeutic procedure that can obviate the need for potentially major surgical intervention. This review will provide the framework for the diagnosis and management of ampullary lesions from the perspective of the practicing gastroenterologist. Strategies for safe and successful endoscopic ampullectomy with a focus on accurate preoperative diagnosis and staging, resection technique, and management of complications are presented. Core tip: Adenomatous ampullary lesions are rare. Endoscopic retrograde cholangiopancreatography and endoscopic ultrasound (EUS) have changed the management of patients with these lesions. Endoscopic ampullectomy is a technique that has revolutionized the treatment of these lesions avoiding potential complications of surgery. We herein discuss the epidemiology, the role of EUS in the local staging and the role of endoscopy in the treatment of the adenomatous ampullary neoplasms.Espinel J, Pinedo E, Ojeda V, Guerra del Rio M. Endoscopic management of adenomatous ampullary lesions. World J REVIEW

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Local resection of benign periampullary tumors

Cited by 34 publications

References 15 publications

Neoplasms of the Ampulla of Vater with Concurrent Pancreatic Intraductal Neoplasia: A Histological and Molecular Study

Neoplasms of the Ampulla of Vater with Concurrent Pancreatic Intraductal Neoplasia: A Histological and Molecular Study

Review on Clinical and Molecular Diagnosis of Periampullary carcinoma

Endoscopic management of adenomatous ampullary lesions

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