Local Regulation of Blood Flow

Siegel, G.; Walter, Axel; Thiel, M.; Ebeling, B. J.

doi:10.1007/978-1-4684-1188-1_47

Cited by 14 publications

(1 citation statement)

References 18 publications

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“…Its activation would lead to a change in vascular tone depending on the basal level of wall tone [3,4,13]. The flow sensor could be a glycosaminoglycan which can increase the availability of its anionic sites to which Na+ can bind under shear stress conditions [28,29], The dependence of flow responses on such an extracellular Na+-dependent site would explain the sensi tivity of the flow response to small changes in extracellu lar Na+ in rabbit resistance arteries [2][3][4] and in the RFV [10]. Vessel wall Na+ is mainly located in the extracellular space which contains proteoglycans forming water-filled compartments with low conductivity [30], The extracellu lar concentration of Na+ increases in vessels from hyper tensive subjects, suggesting a possible link between extra cellular Na+ and vessel tone [27], Flow increased 22Na+ compared to 45Ca2+ net uptake by a much greater amount (7.9-fold) than exposure to histamine.…”

Section: Discussionmentioning

confidence: 99%

Intraluminal Flow Preferentially Increases Net Sodium Uptake in the Rabbit Facial Vein

Henrion

Bevan²

1995

J Vasc Res

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The infusion of physiological salt solution into the lumen of ring segments of the isolated rabbit facial vein induces an increase in vessel wall tone. Changes in ²²Na⁺ and ⁴⁵Ca²⁺ net uptake as well as ²²Na⁺ unidirectional efflux in response to flow in this vessel were compared to the response to histamine (1 µM) and to angiotensin II (0.1 µM). ²²Na⁺ net uptake per unit force developed in response to flow was 7.9-fold greater than that for histamine (1 µM) and twice that for angiotensin II (0.1 µM). In comparison, ⁴⁵Ca²⁺ net uptake per unit force in response to flow, histamine and K⁺ were similar. Flow-induced contraction and the related ⁴⁵Ca²⁺ and ²²Na⁺ net uptake were decreased by amiloride (30 µM) and methyl isobutyl amiloride (30 µM) without changes in ⁴⁵Ca²⁺ or ²²Na⁺ net uptake per unit force. Ouabain (10 µM) enhanced flow-induced contraction and the related ²²Na⁺ net uptake. Both ouabain (10 µM) and Bay K 8644 (1 µM) increased flow-induced contraction and the related ⁴⁵Ca²⁺ net uptake whereas they decreased the ⁴⁵Ca²⁺ net uptake per unit force. Flow, histamine and angiotensin II increased the unidirectional efflux of ²²Na⁺. This increase in ²²Na⁺ unidirectional efflux was attenuated by ouabain (10 µM). These experiments demonstrate that the increases in wall force due to flow, histamine and angiotensin II are associated with increases in ²²Na⁺ net uptake and unidirectional efflux. Flow preferentially promotes the entry of Na⁺, compared to histamine and angiotensin II.