Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983

Tanis, E.; Nordlinger, Bernard; Mauer, Murielle; Sørbye, Halfdan; Coevorden, Frits van; Gruenberger, Thomas; Schlag, Peter M.; Punt, C.J.A.; Ledermann, Jonathan A.; Ruers, Theo J.M.

doi:10.1016/j.ejca.2013.12.008

Cited by 185 publications

(107 citation statements)

References 15 publications

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“…our results are also supported by the results of a recently published study (29) that reports local tumor recurrence after RFA and surgical resection in two independent European organisation for Research and treatment of Cancer (EoRtC) studies. In that study, local recurrence rate per lesion after RFA or surgery was not significantly different in lesions up to 3 cm.…”

Section: Discussionsupporting

confidence: 80%

Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation of Recurrent Colorectal Cancer Liver Metastases after Hepatectomy

et al. 2014

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Introduction: to assess the results and outcome of radiofrequency ablation in the treatment of recurrent colorectal liver metastases.Patients and Methods: between January 2005 and September 2012, we treated 59 patients with recurrent colorectal metastases not amenable to surgery with 77 radiofrequency ablation procedures. radiofrequency was indicated if oncologic resection was technically not possible or the patient was not fit for major surgery. a total of 91 lesions were treated. the mean number of liver tumors per patient was 1.5, and the mean tumor diameter was 2.3 cm. in 37.5% of the cases, lesions had a subcapsular location, and 34% were close to a vascular structure.Results: the morbidity rate was 18.7%, and there were no post-procedural deaths. distant extrahepatic recurrence appeared in 50% of the patients. local recurrence at the site of ablation appeared in 18% of the lesions. local recurrence rate was 6% in lesions less than 3 cm and 52% in lesions larger than 3 cm. the size of the lesions (more than 3 cm) was an independent risk factor for local recurrence (p < 0.05). Survival rates at 1, 3, and 5 years were 94.5%, 65.3%, and 21.7%, respectively. Discussion: radiofrequency ablation is a safe procedure and allows local tumor control in lesions less than 30 mm (local recurrence of 6%) and provides survival benefits in patients with recurrent colorectal liver metastases.

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Section: Discussionsupporting

confidence: 80%

Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation of Recurrent Colorectal Cancer Liver Metastases after Hepatectomy

et al. 2014

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“…Data on oligometastases of lung cancer have frequently been reported [21,22,23]. Oligometastatic prostate cancer and oligometastatic liver disease in colorectal cancer are also often discussed [5,24,25,26]. So far, malignant melanoma and malignancies of the cervix and breast are reported less frequently in the context of oligometastasis [27,28,29].…”

Section: Discussionmentioning

confidence: 99%

Multidisciplinary Tumor Board Recommendations for Oligometastatic Malignancies: A Prospective Single-Center Analysis

et al. 2019

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Background: The treatment of oligometastatic disease is challenging and few data exist to guide treatment decisions. The objective of this study was to improve the data on the prevalence and treatment of patients with oligometastatic disease. Methods: We conducted a prospective single-center analysis that included all consecutive patients discussed in multidisciplinary tumor boards (MDT) between February and July 2017. Patients with oligometastatic disease were identified and treatment strategies were evaluated. Results: 1,673 patients were included in this study, 609 (36.4%) presented with metastatic disease, 151 (9%) had oligometastatic disease. Common metastatic sites were brain, liver, and lung. Lung cancer patients were the largest cohort (20.5%) among all patients with oligometastatic disease compared with other tumor entities. The majority of oligometastatic patients (68.9%) received local treatment with or without additional chemotherapy, 17.9% were recommended systemic therapy alone. MDT recommended watchful waiting for 4.6% of the patients. Conclusion: Patients with oligometastatic disease represent a considerable proportion of all patients in MDT. In this study, 68.9% of patients with oligometastatic disease received regional treatment. This shows a possible treatment shift from palliative to potentially curative intent. These data may be used to design prospective clinical trials to optimize the treatment of oligometastatic disease.

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“…Size of the initial lesion has also been shown to be a predictive factor for local tumor progression, with lesions >3 cm in size having recurrence rates up to seven times higher than those <3 cm in size (18). Although this may be a factor in some cases, other biological factors should still be considered, rather than simply an arbitrary size cutoff.…”

Section: Discussionmentioning

confidence: 99%

Local tumor progression patterns after radiofrequency ablation of colorectal cancer liver metastases

Napoleone

Kielar²,

Hibbert³

et al. 2016

Diagn Interv Radiol

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Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983

Cited by 185 publications

References 15 publications

Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation of Recurrent Colorectal Cancer Liver Metastases after Hepatectomy

Safety and Efficacy of Ultrasound-Guided Radiofrequency Ablation of Recurrent Colorectal Cancer Liver Metastases after Hepatectomy

Multidisciplinary Tumor Board Recommendations for Oligometastatic Malignancies: A Prospective Single-Center Analysis

Local tumor progression patterns after radiofrequency ablation of colorectal cancer liver metastases

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