Local recurrence of brain metastasis reduced by intra-operative hyperthermia treatment

Abstract

Purpose: Brain metastasis is a common complication in cancer patients. Local recurrence after total resection of metastatic brain tumor has been frequently reported. In this study, we developed a new hyperthermia device and applied it to metastatic brain tumor patients intra-operatively to study if hyperthermia treatment could reduce local tumor recurrence. Materials and methods: A total of 63 metastatic brain patients were enrolled in the study with an informed consent obtained from every patient. After total resection of the tumor, the hyperthermia device was applied intra-operatively to the resection cavity. The surrounding brain tissue at 5 mm in depth from the tumor resection margin was raised to 42.5 C for a total of 60 minutes (Clinical Research Information Service Registration Number: KCT0001308). Results: A total of 10 local recurrences were observed in 63 patients who received hyperthermia treatment showing a local recurrence rate of 15.8%. It was significantly lower than the local recurrence rate of those who received conventional treatment (34%) when analyzed with one tailed z-test (p value: .001). Kaplan-Meier analysis also showed a significantly lower recurrence rate in the hyperthermia treatment group (p value: .0003). Complications included two cases of seizures and two cases of wound infection. Conclusions: Results of this study suggest that intra-operative hyperthermia treatment after total resection of metastatic brain tumor could reduce local recurrence of tumor. We believe that intraoperative hyperthermia treatment could be used as an adjuvant therapy to surgery and post-operative radiotherapy, or as a salvage treatment in patients who cannot receive further radiotherapy.

Clinical Significance of Precise Hyperthermic Intraperitoneal Chemotherapy Up-regulation RP11-356I2.2 Restraining the Occurrence and Development of Gastric Cancer

“…Some studies have also shown that hyperthermia can enhance the immune attack on tumors (Frey et al, 2012). Studies have shown that postoperative hyperthermia can reduce local recurrence of brain metastases (Byun et al, 2018). HIPEC has traditionally been used for the treatment of peritoneal cancer and in combination with tumor Cell Reduction Surgery (CRS).…”

Hyperthermia treatment advances for brain tumors

“…HT intracavitary devices have also been developed and reported in a phase I clinical trial [248]. This devise is comprised of a water pump that circulates hot water to a cavitated gold coated sphere.…”

“…Design HT modality Brain tumor type Byun et al [248] Clinical Novel hyperthermia device BM Schooneveldt et al [247] Clinical M/W PT Bredlau et al [244] Preclinical R/F Canines with no tumors Rozumenko et al [249] Clinical LSTT HGGs Roussakow SV, 2017 [246] Clinical EHT HGGs Cha et al [243] Preclinical EHT Human GBM (U87-MG þ A172) Man et al [32] Preclinical M/W Human GBM (patient derived glioma stem cells specimens 3691 and 387) Coluccia et al [237] Clinical U/S HGGs James et al [14] Preclinical R/F Rodent glioma (9L gliosarcoma) McDannold et al [236] Clinical U/S HGGs Wismeth et al [245] Clinical EHT HGGs Park et al [238] Clinical U/S HGGs HT: hyperthermia; R/F: radio-frequency hyperthermia; EHT: electro-hyperthermia; U/S: ultrasound; M/W: microwave hyperthermia; LSTT: laser surface thermal therapy; BM: brain metastasis; HGGs: high grade gliomas; PT: pediatric tumor.…”

Мёссбауэровские исследования состава и магнитной структуры нанокомпозитов Fe-=SUB=-3-=/SUB=-O-=SUB=-4-=/SUB=-/γFe-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=- типа ядро--оболочка при температура 300 и 80 K (Часть I)

“…[5]. При достижении температур 42−44 • C злокачественные клетки погибают, тогда как здоровые клетки не повреждаются [4][5][6][7]. МГТ лечение с использованием локализованных в опухоль МНЧ является одним из наиболее перспективных методов лечения агрессивного, разрушительного и не поддающегося лечению рака головного мозгаглиобластомы [8].…”