Local recurrence in rectal cancer can be predicted by histopathological factors

Dresen, Raphaëla C.; Peters, Elke E.M.; Rutten, H.J.T.; Nieuwenhuijzen, Grard A. P.; Demeyere, Thomas; Brule, Adriaan J. C. van den; Kessels, Alfons; Beets‐Tan, Regina G. H.; Krieken, J.H.J.M. van; Nagtegaal, Irıs D.

doi:10.1016/j.ejso.2009.03.007

Cited by 79 publications

(36 citation statements)

References 29 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, a trend for increased risk of death (HR ¼ 1.9; P ¼ 0.065) was recorded that did not reach statistical significance probably due to the limited number of events occurring during the short follow-up period. In contrast, the presence of CVE was revealed as an independent prognostic factor for decreased OS in agreement with several previous reports (25,26). In addition, in the subset of patients with available specimen at the completion of the adjuvant chemotherapy, the persistence of CEACAM5mRNA-positive cells was a strong prognostic factor of decreased DFS and OS.…”

Section: Discussionsupporting

confidence: 52%

Prognostic Significance of the Detection of Peripheral Blood CEACAM5mRNA-Positive Cells by Real-Time Polymerase Chain Reaction in Operable Colorectal Cancer

Vardakis

Messaritakis

Papadaki

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: To evaluate the clinical relevance of circulating CEACAM5mRNA-positive cells in patients with operable colorectal cancer (CRC).Methods: Peripheral blood was obtained from 265 patients with operable CRC before the initiation of adjuvant systemic therapy from 96 normal donors and RNA prepared from the Lovo and ARH-77 CRC and leukemic cell lines, respectively, was used as positive and negative controls. The detection of CEACAM5mRNA-positive cells was done using a real-time PCR assay. The association with known prognostic factors and the effect of CEACAM5mRNA-positive cells on patients' prognosis was investigated.Results: The analytical detection limit of the method was found to correspond to 0.7 Lovo cell equivalence/5 mg RNA, with a sensitivity of 1 tumor cell/10 5 normal cells and a specificity of 97%.Ninety-eight (37%) patients had detectable circulating CEACAM5mRNA-positive cells. Detection of CEACAM5mRNA-positive cells was significantly associated with higher relapse rate (P < 0.001), decreased disease-free survival (DFS; P < 0.001), higher death rate (P ¼ 0.017), and decreased median overall survival (P ¼ 0.025). Multivariate analysis revealed that the detection of circulating CEACAM5mRNA-positive cells was an independent prognostic factor for decreased DFS [HR ¼ 3.4; 95% CI: 2.0-5.9; P < 0.001].Conclusions: Detection of peripheral blood CEACAM5mRNA-positive cells is an adverse prognostic factor correlated with poor clinical outcome in patients with operable CRC.

show abstract

Section: Discussionsupporting

confidence: 52%

Prognostic Significance of the Detection of Peripheral Blood CEACAM5mRNA-Positive Cells by Real-Time Polymerase Chain Reaction in Operable Colorectal Cancer

Vardakis

Messaritakis

Papadaki

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

show abstract

“…In conclusion, optimal tuning of multimodal treatment options including aggressive surgical regimens may result in maximized disease-free survival of approximately 30% [78,79,80] and an overall survival of roughly 50% at 5 years when an R0 resection for locally recurrent CRC is achieved [78,79,80,81]. …”

Section: Recurrent Diseasementioning

confidence: 99%

Surgery for Colorectal Cancer - Trends, Developments, and Future Perspectives

et al. 2016

View full text Add to dashboard Cite

Background: Although colorectal surgery is long established as the mainstay treatment for colon cancer, certain topics regarding technical fine-tuning to increase postsurgical recurrence-free survival have remained a matter of debate throughout the past years. These include complete mesocolic excision (CME), treatment strategies for metastatic disease, significance of hyperthermic intraperitoneal chemotherapy (HIPEC), and surgical techniques for the treatment of colorectal cancer recurrence. In addition, new surgical techniques have been introduced in oncologic colorectal surgery, and their potential to provide sufficiently radical resection has yet to be proven. Methods: A structured review of the literature was performed to identify the current state of the art with regard to the mentioned key issues in colorectal surgery. Results: This article provides a comprehensive review of the current literature addressing the above-mentioned current challenges in colorectal surgery. The focus lies on the impact of CME and, in relation to this, on lymph node dissection, as well as on treatment of metastatic disease including peritoneal spread, and finally on the treatment of recurrent disease. Conclusion: Uniformly, the current literature reveals that surgery aiming at complete malignancy elimination within multimodal treatment approaches represents the fundamental quantum leap for the achievement of long-term tumor-free survival.

show abstract

“…27,41,63 The 2 most important predictors of radical resection of local recurrence are previous anterior resection instead of APR and the absence of pain at the time of recurrence. 43,64,65 Intraluminal recurrences, especially after initial local excision, are separated from the bony pelvis and sacral nerves by remaining soft tissue, thereby not resulting in pain and enabling resection with adequate margins in almost all patients. 26,35,39 Given the worse outcome for local recurrence after prior APR, optimal primary treatment of distal cancers is of utmost importance.…”

Section: Discussionmentioning

confidence: 99%

Intentionally curative treatment of locally recurrent rectal cancer: a systematic review

Tanis

Doeksen

Lanschot

2013

cjs

View full text Add to dashboard Cite

Intentionally curative treatment of locally recurrent rectal cancer: a systematic reviewBackground: There is a lack of outcome data beyond local recurrence rates after primary treatment in rectal cancer, despite more information being necessary for clinical decision-making. We sought to determine patient selection, therapeutic modalities and outcomes of locally recurrent rectal cancer treated with curative intent. Methods:We searched MEDLINE (1990-2010) using the medical subject headings "rectal neoplasms" and "neoplasm recurrence, local." Selection of cohort studies was based on the primary intention of treatment and availability of at least 1 outcome variable. Results:We included 55 cohort studies comprising 3767 patients; 8 studies provided data on the rate of intentionally curative treatment from an unselected consecutive cohort of patients (481 of 1188 patients; 40%). Patients were symptomatic with pain in 50% (796 of 1607) of cases. Overall, 3088 of 3767 patients underwent resection. The R0 resection rate was 56% (1484 of 2637 patients). The rate of external beam radiotherapy was 100% in 9 studies, 0% in 5 studies, and ranged from 12% to 97% in 37 studies. Overall postoperative mortality was 2.2% (57 of 2515 patients). Five-year survival was at least 25%, with an upper limit of 41% in 11 of 18 studies including at least 50 resections. We found a significant increase in reported survival rates over time (r 2 = 0.214, p = 0.007). Conclusion:More uniformity in treatment protocols and reporting on outcomes for locally recurrent rectal cancer is warranted. The observed improvement of reported survival rates in time is probably related to better patient selection and optimized multimodality treatment in specialized centres.

show abstract

Local recurrence in rectal cancer can be predicted by histopathological factors

Cited by 79 publications

References 29 publications

Prognostic Significance of the Detection of Peripheral Blood CEACAM5mRNA-Positive Cells by Real-Time Polymerase Chain Reaction in Operable Colorectal Cancer

Prognostic Significance of the Detection of Peripheral Blood CEACAM5mRNA-Positive Cells by Real-Time Polymerase Chain Reaction in Operable Colorectal Cancer

Surgery for Colorectal Cancer - Trends, Developments, and Future Perspectives

Intentionally curative treatment of locally recurrent rectal cancer: a systematic review

Contact Info

Product

Resources

About