Local recurrence and metastatic disease in a typical N1 carcinoid bronchial tumour

Cañizares, M.A.; García-Fontán, Eva; Rivo, José Eduardo; González-Piñeiro, Ana

doi:10.1007/bf02712820

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…Metastatic disease for atypical carcinoid tumors was noted primarily in the bone [26], brain [27], and liver [23], which is consistent with previous reports. We note that for typical carcinoid the most common site of metastasis, when metastasis occurs at all, was the liver and bone, also consistent with previous case reports [26], [28] and [29]. …”

Section: Discussionsupporting

confidence: 92%

Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors

et al. 2014

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Objectives The optimal management of locally advanced and metastatic pulmonary carcinoid tumors remains to be determined. Materials and methods A retrospective review was conducted on patients with typical and atypical pulmonary carcinoid tumors treated at our institutions between 1990 and 2012. Results 300 patients were identified with pulmonary carcinoid, (80 patients with atypical carcinoid), of whom 29 presented with metastatic disease (16 atypical). Of evaluable patients, 26 (41%) with stages I–III atypical carcinoid tumors recurred at a median time of 3.7 years (range, 0.4–32), compared to 3 (1%) patients with typical carcinoid (range, 8–12.3). 39 patients were treated with chemotherapy, including 30 patients with metastatic disease (27 atypical), and 7 patients were treated with adjuvant platinum–etoposide chemoradiation (6 atypical, 1 typical, 6 stage IIIA, 1 stage IIB). At a median follow-up of 2 years there were 2 recurrences in the 7 patients receiving adjuvant treatment. Median survival after diagnosis of metastatic disease for patients with atypical pulmonary carcinoid was 3.3 years with a 5-year survival of 24%. Treatment regimens showing efficacy in pulmonary carcinoid include 15 patients treated with octreotide-based therapies (10% response rate (RR), 70% disease control rate (DCR), 15 month median progression-free survival (PFS)), 13 patients treated with etoposide + platinum (23% RR, 69% DCR, 7 month median PFS), and 14 patients treated with temozolomide-based therapies (14% RR, 57% DCR, 10 month median PFS). 8 of 10 patients with octreotide-avid disease treated with an octreotide-based regimen experienced disease control (1 partial response, 7 stable disease) for a median of 18 months (range 6–72 months). Conclusions These results support our previous finding that a subset of pulmonary carcinoid tumors are responsive to chemotherapy.

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Section: Discussionsupporting

confidence: 92%

Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors

et al. 2014

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“…This is contrary to the results reported by Fink et al [21] and Anne Naalsund et al [22] who introduced the right lobe, or Davila DG et al [23] who reported the lower right and left lobes as the most affected sites. Surgery was the most common treatment in our study and lobectomy was performed more than pneumonectomy, which was similar to other studies [24][25][26][27]. Morandi et al [28] reported in 2006 that carcinoid tumors had an equal prevalence between male and female patients and appeared to occur in women at a younger age than men (although this difference was not statistically significant).…”

Section: Discussionsupporting

confidence: 90%

Evaluation of demographic and rare clinical characteristics of patients with thoracic carcinoid tumor in Razi and Aria Hospitals of Rasht during 2006-2019

Aghajanzadeh¹,

Foumani²,

Tangestaninejad³

et al. 2022

GSC Adv. Res. Rev.

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Introduction: Carcinoid tumors are malignant neoplasms of low-malignant neuroendocrine cells. This study tended to evaluate the demographic and rare clinical characteristics of patients with thoracic carcinoid tumor during 2006-2016 at Razi and Aria Hospitals in Rasht. Materials and Methods: The present study was performed on records of 43 patients with lung carcinoid tumors referred to Razi and Aria Hospitals of Rasht during 2006-2019. Information on age, gender, rare clinical symptoms, smoking history, diagnosis tools, treatment and outcome were analyzed. Results: Of the 43 patients treated with definitive diagnosis of carcinoid tumor pathology, 31 patients had typic carcinoid tumor and 12 patients had atypic carcinoma (mean age 43.14±15.16 years). The most common clinical symptom was cough and hemoptysis. Two cases presented with Cushing’s syndrome. The most common diagnostic method in this study was simultaneous use of both CT scan and bronchoscopy. In 95.3% of cases, the tumor manifested as pulmonary and in 4.7% of cases it was extrapulmonary. Right lower lobe was the most common site of tumor involvement and lobectomy was the most frequent surgical procedure performed. Conclusion: based upon our study the most common clinical sign of thoracic carcinoid was cough and the tumor was pulmonary in 95.3% of cases. Right lower lobe was the most common site of involvement and the most frequent surgical procedure performed was lobectomy. The outcome was good.

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“…Surgery was the most common treatment in our study and lobectomy was performed more than pneumonectomy, which was similar to other studies. [ 25 26 27 28 ] Morandi et al . [ 29 ] reported in 2006 that carcinoid tumors had an equal prevalence of gender and appeared to occur in women at a younger age than men (although this difference was not statistically significant).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of demographic and rare clinical characteristics of patients with thoracic carcinoid tumor in Razi and Aria Hospitals of Rasht during 2006-2016

Aghajanzadeh¹,

Asgary²,

Fomani³

et al. 2022

Journal of Family Medicine and Primary Care

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Introduction: Carcinoid tumors are malignant neoplasms of neuroendocrine cells. This study tended to evaluate the demographic and rare clinical characteristics of patients with thoracic carcinoid tumor during 2006-2016 at Razi and Aria Hospitals in Rasht. Materials and Methods: The present study was performed on records of 43 patients with lung carcinoid tumors referred to Razi and Aria Hospitals of Rasht during 2006-2016. Information on age, gender, rare clinical symptoms, smoking history, diagnosis tools, treatment, and outcome were analyzed. Results: Of 43 patients treated with definitive diagnosis of carcinoid tumor pathology, 31 patients had typic carcinoid tumor and 12 patients with atypic carcinoma (mean age 43.14 ± 15.16 years). The most common clinical symptom was cough and hemoptysis. Two cases presented with cushing syndrome, The most common diagnostic method in this study was simultaneous use of both CT scans and bronchoscopy. In 95.3% of cases, the tumor was pulmonary and in 4.7% of cases, it was extrapulmonary. Right lower lobe was the most common site of tumors and most of the surgeries used were lobectomy. Conclusion: This study showed that the most common clinical sign of thoracic carcinoid is cough and the tumor is pulmonary in 95.3% of cases. Right lower lobe was the most common site of tumors and most of the surgeries used were lobectomy. outcome was good.

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Local recurrence and metastatic disease in a typical N1 carcinoid bronchial tumour

Cited by 5 publications

References 11 publications

Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors

Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors

Evaluation of demographic and rare clinical characteristics of patients with thoracic carcinoid tumor in Razi and Aria Hospitals of Rasht during 2006-2019

Evaluation of demographic and rare clinical characteristics of patients with thoracic carcinoid tumor in Razi and Aria Hospitals of Rasht during 2006-2016

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