Local recurrence after mastectomy for breast cancer: analysis of clinicopathological, biological and prognostic characteristics

Carreño, Guillermo Andrés Torres; Casar, José M. del; Corte, M.D.; González, Luis O.; Bongera, Miguel; Merino, Antonio; Juan, Germán; Obregón, Raúl Álvarez; Martı́nez, Enrique; Vizoso, F

doi:10.1007/s10549-006-9310-0

Cited by 44 publications

(27 citation statements)

References 59 publications

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“…Correno did not observe any statistically significant association between AR expression and local recurrences [35], which, however, has not been confirmed in our study.…”

Section: Discussioncontrasting

confidence: 98%

Androgen receptors as a prognostic and predictive factor in breast cancer.

Agrawal

Jeleń²,

Grzebieniak³

et al. 2008

Folia Histochem Cytobiol.

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Many theoretical and experimental models indicate that androgen receptors can play an important role as prognostic factors in breast cancer. The aim of this study was to evaluate the correlations between the presence of androgen receptors on cancer cells and other selected prognostic and predictive factors with established clinical significance in women with breast cancer after radical surgical treatment. 488 adult females were included in the study, who underwent primary radical surgery for breast cancer. 428 patients (87.7%) had Patey's conservative radical mastectomy and 60 (12.3%) Halsted's radical mastectomy. The mean age at operation was 54.3, ranging from 32 to 79. The mean length of hospitalization was 7.2 days for the patients after Patey's mastectomy and 9.8 days for those after Halsted's mastectomy. The androgen receptor is the most frequently detected steroid receptor on breast cancer cells. Therapeutic efficacy of adjuvant hormone therapy was higher in the group of androgen receptor-positive patients than in androgen receptor-negative ones. The prognosis for androgen receptor-positive patients who underwent adjuvant hormone therapy was better than for those androgen receptor-positive patients who did not receive hormone therapy after primary radical surgery for breast cancer. Assessment of androgen receptor levels on cancer cells should become a routine procedure with patients undergoing primary radical surgery for breast cancer, as it seems to be an important predictive factor.

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“…Correno did not observe any statistically significant association between AR expression and local recurrences [35], which, however, has not been confirmed in our study.…”

Section: Discussioncontrasting

confidence: 98%

Androgen receptors as a prognostic and predictive factor in breast cancer.

Agrawal

Jeleń²,

Grzebieniak³

et al. 2008

Folia Histochem Cytobiol.

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“…Recurrence appeared to be stage-dependent and independent of the use of IBR. In addition, this wide range is possibly due to potential bias because of inadequate axillary sampling, incomplete surgical technique, and suboptimal systemic therapy [56]. A recent pooled analysis by Jatoi and Proschan of six randomized trials comparing mastectomy and breast conservation in the treatment of primary breast cancer examined mortality and LR [57].…”

Section: Discussionmentioning

confidence: 99%

New concept for immediate breast reconstruction for invasive cancers: feasibility, oncological safety and esthetic outcome of post-neoadjuvant therapy immediate breast reconstruction versus delayed breast reconstruction: a prospective pilot study

Giacalone

Rathat

Daurès

et al. 2010

Breast Cancer Res Treat

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Feasibility and oncological safety of postadjuvant skin-sparing mastectomy (SSM) plus immediate breast reconstruction (IBR) cannot be evaluated by randomized trials. However, comparative study could modify guidelines for the oncosurgical treatment of invasive breast cancer. Our study compared the feasibility, oncological safety and esthetic outcome of SSM plus latissimus dorsi (LD) flap IBR after chemotherapy (CT) and radiotherapy (RT) with the standard management for invasive breast cancer: mastectomy as primary treatment, adjuvant CT and RT, and LD flap delayed breast reconstruction (DBR). Twenty-six selected patients with stages IIA-IIIA breast cancer were offered post-neoadjuvant SSM plus IBR with LD flap plus implant (IBR group). Seventy-eight other patients had primary mastectomy, adjuvant CT and RT, and LD-assisted DBR (DBR group). After 4.1 years (range 1-8) of follow-up, feasibility, oncological safety, and esthetic outcome were compared. Sixteen (61%) early complications were reported for the IBR group versus 44 (56%) for the DBR group (P = 0.645). Early implant loss was 0% in IBR versus 12% in DBR. IBR had 8 (30%) late complications versus 17 (21%) for DBR (P = 0.362). Capsular contracture and reconstruction failure rates were similar. Local recurrence was 7.7% (2/26) in IBR and 6.4% (5/78) in DBR (P = 0.823). Cosmetic evaluation by independent physicians and by the patients themselves was identical in the two groups. Our concept provides a basis for offering more women the opportunity to elect for immediate reconstruction, even in the setting of radiation therapy.

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“…Carreno et al [33] did not find any prognostic value for IHC-AR N with regard to local recurrence using a single TMA core from 25 patients. This is in agreement with our observations, which showed no prognostic information regarding RFS (Table II).…”

Section: Journal Of Surgical Oncologymentioning

confidence: 92%