Local Recurrence After Laparoscopic Radiofrequency Thermal Ablation of Hepatic Tumors

Siperstein, Allan; Garland, Adella M.; Engle, K. L.; Rogers, Stanley J.; Berber, Eren; Foroutani, Arash; String, A.; Ryan, Tamara; Ituarte, Philip H.G.

doi:10.1007/s10434-000-0106-x

Cited by 212 publications

(125 citation statements)

References 23 publications

(26 reference statements)

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“…However, they also reported that there were no significant differences of overall and disease-free survival between surgical resection and rFA when the patients were in child-Pugh class B (8). the incidence of local failure after RFA was reported to be as low as 1.8%, but reached 12-18% as reported by other authors (21)(22)(23). In our department, the local recurrence rate after rFA is higher compared with that for surgery, but the difference is not significant (8.3 vs. 1.3%, p=0.13).…”

Section: Discussionsupporting

confidence: 48%

Radiofrequency ablation induces dedifferentiation of hepatocellular carcinoma

Tajima¹,

Ohta²,

Okamoto³

et al. 2010

Oncology Letters

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Section: Discussionsupporting

confidence: 48%

Radiofrequency ablation induces dedifferentiation of hepatocellular carcinoma

Tajima¹,

Ohta²,

Okamoto³

et al. 2010

Oncology Letters

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“…40 Our local recurrence rate of 3.6% after RFA of HCC is similar to local recurrence rates of 6% to 12% reported in recent surgical RFA series. 17,18 Currently, we are evaluating color flow Doppler ultrasonography with and without intravenously administered ultrasound contrast (Levovist, Schering Plough, Kenilworth, NJ) to determine whether this technique will improve our accuracy in monitoring the zone of coagulative necrosis induced by RFA, thus reducing the incidence of incomplete treatment and local recurrence.…”

Section: Discussionmentioning

confidence: 99%

Radiofrequency Ablation of Hepatocellular Cancer in 110 Patients With Cirrhosis

et al. 2000

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ObjectiveTo determine the treatment efficacy, safety, local tumor control, and complications related to radiofrequency ablation (RFA) in patients with cirrhosis and unresectable hepatocellular carcinoma (HCC). Summary Background DataMost patients with HCC are not candidates for resection because of tumor size, location, or hepatic dysfunction related to cirrhosis. RFA is a technique that permits in situ destruction of tumors by means of local tissue heating. MethodsOne hundred ten patients with cirrhosis and HCC (Child class A, 50; B, 31; C, 29) were treated during a prospective study using RFA. Patients were treated with RFA using an open laparotomy, laparoscopic, or percutaneous approach with ultrasound guidance to place the RF needle electrode into the hepatic tumors. All patients were followed up at regular intervals to detect treatment-related complications or recurrence of disease. ResultsAll 110 patients were followed up for at least 12 months after RFA (median follow-up 19 months). Percutaneous or intraoperative RFA was performed in 76 (69%) and 34 patients (31%), respectively. A total of 149 discrete HCC tumor nodules were treated with RFA. The median diameter of tumors treated percutaneously (2.8 cm) was smaller than that of lesions treated during laparotomy (4.6 cm). Local tumor recurrence at the RFA site developed in four patients (3.6%); recurrent HCC subsequently developed in other areas of the liver in all four. New liver tumors or extrahepatic metastases developed in 50 patients (45.5%), but 56 patients (50.9%) had no evidence of recurrence. There were no treatment-related deaths, but complications developed in 14 patients (12.7%) after RFA.

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“…Depending on the tumor location, RFA can be performed laparoscopically or percutaneously [125,126,127,128,129,130]. Existing data report on all kinds of endocrine tumors.…”

Section: Locoregional Ablative Therapymentioning

confidence: 99%