Local Reactions to I.V. Diazepam in Three Different Formulations

Olesen, Anne Vingaard; Hüttel, M.

doi:10.1093/bja/52.6.609

Cited by 68 publications

(3 citation statements)

References 6 publications

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“…Os exemplos clássicos de lesões vasculares decorrentes do tipo de drogas são: 1) glicose hipertônica (33) ; 2) diclofenaco (34) ; 3) difenil hidantoína (35) ; 4) diazepan (36) ; 5) praxilene (37) ; 6) epoprostenol (38) ; 7) anfotericina B (39) , além das lesões desencadeadas pela velocidade de infusão (40) . Para os cinco fatores de risco relacionados ao cateter intravascular e a sua permanência num mesmo sítio de inserção, obtivemos três fatores de risco com escores e" 0,80 (quadro 2); foi ainda observado o fator de risco Material de composição da agulha do cateter com escore 0,77 e cor do dispositivo com escore < 0,50.…”

Section: Método Método Método Método Métodounclassified

Risco para trauma vascular: proposta do diagnóstico e validação por peritos

Arreguy-Sena

Carvalho

2009

Rev. Bras. Enferm.

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RESUMO RESUMO RESUMO RESUMO RESUMO Pesquisa de validação conceitual e de conteúdo que objetivou compor o título, os mecanismos de vulnerabilidade e os fatores de risco para o diagnóstico de enfermagem "Risco para Trauma Vascular", segundo a taxonomia da NANDA, bem como validar os elementos desse diagnóstico, a partir da opinião de 60 peritos. Foram identificados 51 fatores relacionados a cinco eixos: medicação e forma/ periodicidade de infusão; cateter intravascular e permanência num mesmo sítio; fixação do cateter intravascular; indivíduo, seus hábitos, padrão comunicacional, estilo de vida e capacidade sensório-motora; e decisões profissionais, política institucional e procedimento. Destes, foram validados 28 fatores de vulnerabilidade (escore e" 0,80). Os resultados evidenciaram "Risco para Trauma Vascular" ser um novo diagnóstico de enfermagem; sugere-se a validação clínica do mesmo. Descritores Descritores Descritores Descritores Descritores: Enfermagem; Processos de enfermagem; Diagnóstico de enfermagem.ABSTRACT ABSTRACT ABSTRACT ABSTRACT ABSTRACT This concept and content validation study aimed to compose the title, vulnerability mechanisms and risk factors for the nursing diagnosis "Risk for Vascular Trauma", according to the taxonomy proposed by NANDA, as well as to validate the elements of this diagnosis, based on 60 experts' opinion. Fifty-one factors were identified, related to five axes: medication and infusion form/periodicity; intravascular catheter and dwelling in the same site; fixation of the intravascular catheter; individuals, their habits, communication standard, lifestyle and sensory-motor ability; and professional decisions, institutional policy and procedures. Among these, 28 vulnerability factors were identified (score e" 0.80). The results evidenced that "Risk for Vascular Trauma" is a new nursing diagnosis, and its clinical validation is suggested. Descriptors: Descriptors: Descriptors: Descriptors: Descriptors: Nursing; Nursing process; Nursing diagnosis. RESUMEN RESUMEN RESUMEN RESUMEN RESUMEN Investigación de validación conceptual y de contenido con objeto de componer el título, los mecanismos de vulnerabilidad y los factores de riesgo para el diagnóstico de enfermería "Riesgo para Trauma Vascular", según la propuesta de la taxonomía de la NANDA, y también validar los elementos de ese diagnóstico, a partir de la opinión de 60 peritos. Fueron identificados 51 factores relacionados a cinco ejes: medicación y forma/periodicidad de infusión; cateter intravascular y permanencia en un mismo sitio; fixación del cateter intravascular; individuo, sus hábitos, patrón comunicacional, estilo de vida y capacidad sensorio-motora; y decisiones profesionales, política institucional y procedimiento. De estos, fueron validados 28 factores de vulnerabilidad (score e" 0,80). Los resultados evidenciaron que "Riesgo para Trauma Vascular" es un nuevo diagnóstico de enfermería; su validación clínica es sugerida. Descriptores Descriptores Descriptores Descriptores Descriptores: Enfermería; Proceso de enferme...

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Section: Método Método Método Método Métodounclassified

Risco para trauma vascular: proposta do diagnóstico e validação por peritos

Arreguy-Sena

Carvalho

2009

Rev. Bras. Enferm.

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“…Low concentration of propylene glycol in intravenous diclofenac injection produced a less adverse effect as compared to high propylene glycol concentration 7,9 . In one study investigators 14 found that diazepam in propylene glycol developed a higher incidence of thrombophlebitis as compared to diazepam dissolved in oil and emulsified in water without loss of therapeutic effect. Among three marketed compounds, Voveran is recommended for intravenous infusion while Jonac AQ and Dynapar AQ are recommended for intravenous bolus and infusion.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

IJPSR

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Diclofenac is the most popular and widely prescribed nonsteroidal anti-inflammatory drug (NSAID). However, no preclinical data are available on repeated diclofenac IV bolus injection. In the present study, forty male Wistar rats were randomly divided in in total of four groups with 10 rats in each group. The control group received 0.9% sodium chloride injection. Marketed injectable Diclofenac Sodium formulations of Jonac AQ (75 mg/mL), Dynapar AQ (75 mg/mL) and Voveran (75 mg/mL) were administered in group 2, 3 and 4 respectively @ 15.4 mg/kg body weight as IV bolus injection daily for seven days in the lateral tail vein. At the end of seven days treatment period, six animals per group were sacrificed. The remaining four animals per group were sacrificed after seven days recovery period. On day 8 of the study, 9/10 rats in the Voveran group, 10/10 rats in the Dynapar AQ group and 6/10 rats in Jonac AQ group showed an injection site reaction. On day 15 (reversal necropsy) of the study, 4/4 rats in Voveran group, 4/4 rats in the Dynapar AQ group and 3/4 rats in Jonac AQ group showed injection site reaction. Microscopically, intravenous injection of Jonac AQ, Dynapar AQ and Voveran induced necrosis of tail skin, thrombosis and/or thrombophlebitis, degeneration/regeneration of skeletal muscles and subcutaneous fibrosis of variable severity. In conclusion, macroscopically and microscopically, among all three marketed Diclofenac Sodium injections, Voveran group caused more severe local reaction followed by the Dynapar AQ group while Jonac AQ injection was better tolerated and revealed less severe reaction at the local injection site.

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“…It is an oil-in-water emulsion in which the active ingredient, diazepam, has been dissolved in the oil phase ( 1 ). The frequency of localized venous side-effects using this preparation is lower than for water-based solutions of diazepam (2), which all contain several pharmacologically active organic solvents (3,4).…”

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confidence: 96%

Intravenous infusion of Diazemuls® in the control of status‐like epileptic seizures of different etiology

Høgskilde

Sørensen

Thisted

et al. 1987

Acta Anaesthesiol Scand

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This report concerns three patients in whom continuous intravenous infusion of Diazemuls (diazepam dissolved in soya bean oil and emulsified) diluted in 5.5% glucose was used for the controlling of epileptic seizures (status). Diazemuls infusion was effective in one patient with complex partial status epilepticus; in another patient with convulsion secondary to a brain stem infarct, the convulsions were abolished; while only reduced jerking was achieved in the third patient suffering from myoclonic jerks caused by anoxic brain damage. Infusion time ranged from 15 to 33 h. The serum concentrations of diazepam obtained during the infusions were higher than recommended in the literature for treatment of status epilepticus, but could not be correlated to either clinical efficacy or infusion rate.

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Local Reactions to I.V. Diazepam in Three Different Formulations

Cited by 68 publications

References 6 publications

Risco para trauma vascular: proposta do diagnóstico e validação por peritos

Risco para trauma vascular: proposta do diagnóstico e validação por peritos

Untitled

Intravenous infusion of Diazemuls® in the control of status‐like epileptic seizures of different etiology

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