Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium

Zidi, Sourour; Bediar-Boulaneb, F; Belguendouz, Houda; Belkhelfa, Mourad; Medjeber, Oussama; Laouar, Omar; Henchiri, Cherifa; Touil-Boukoffa, Chafia

doi:10.1177/0394632017742505

Cited by 18 publications

(12 citation statements)

References 43 publications

(80 reference statements)

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“…In addition, IL-6 and other UVB-associated proinflammatory secretions contribute to the infiltration of different immune cells that produce proangiogenic factors [35, 36]. Further substantiating our hypothesis of an enhanced tear film cytokine production are the increased IL-6 levels found in reflex tears of pterygium patients [37]. However, to our knowledge, no report has yet been published regarding the course of these proinflammatory cytokine levels after surgical intervention and into the recovery period post pterygiectomy.…”

Section: Introductionsupporting

confidence: 63%

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

Acker

Haagdorens

Roelant

et al. 2019

Mediators of Inflammation

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Pterygium is a common eye disease, linked to an increased exposure to UV radiation and dry environments. The associated pathology culminates in visual impairment and, in some rare cases, blindness. However, there remains a lot of uncertainty concerning the pathogenesis of this fibrovascular lesion. As the composition of the tear film provides a reflection into the pathological changes at the ocular surface, tear analysis represents an ideal approach to gain insight in the progression of disease following pterygiectomy. This study enrolled 19 patients and age/gender-matched healthy controls. Tear film levels of interleukin- (IL-) 6, IL-8, and vascular endothelial growth factor (VEGF) were investigated over time, and preoperative concentrations were linked to corneal neovascularization and pterygium size. Diminished tear film levels were found in unilateral patients who show no clinical signs of pterygium recurrence over a period of one year. Hence, our results highlight the potential of using the course of IL-6, IL-8, and VEGF levels in tears as biomarkers for recovery. In addition, when focusing on the affected eyes (i.e., primary and recurrent pterygium), we detected fold changes in preoperative cytokine concentrations to correspond with disease severity. As our proposed biomarkers did not reveal a linear relationship with corneal neovascularization nor the invasive behaviour of pterygium, no exact role in the pterygium pathology could be established. Hence, our data point to these factors being contributors rather than decisive players in the pathological processes.

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Section: Introductionsupporting

confidence: 63%

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

Acker

Haagdorens

Roelant

et al. 2019

Mediators of Inflammation

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“…Various studies have shown that LPS stimulation induces the secretion of various proinflammatory mediators, such as NO and ROS [24, 25]. The production and secretion of NO can induce local tissue damage and further trigger inflammation [26]. Therefore, the inhibition of NO production is an important therapeutic strategy for the treatment of inflammatory diseases [27].…”

Section: Discussionmentioning

confidence: 99%

SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway

Chen

et al. 2019

Oxidative Medicine and Cellular Longevity

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Mastitis has severely affected the cattle industry worldwide and has resulted in decreased dairy production and cattle reproduction. Although prevention and treatment methods have been implemented for decades, cattle mastitis is still an intractable disease. Sirtuin 7 (SIRT7) is an NAD+-dependent deacetylase that is involved in various biological processes, including ribosomal RNA synthesis and protein synthesis, DNA damage response, metabolism, and tumorigenesis. However, whether SIRT7 participates in inflammation remains unknown. Our results revealed that SIRT7 is downregulated in tissue samples from mastitic cattle. Therefore, we isolated dairy cow mammary epithelial cells (DCMECs) from breast tissues and developed an in vitro model of lipopolysaccharide- (LPS-) induced inflammation to examine SIRT7 function and its potential role in inflammation. We showed that SIRT7 was significantly downregulated in LPS-treated DCMECs. SIRT7 knockdown significantly increased the LPS-stimulated production of inflammatory mediators, like reactive oxygen and nitric oxide, and upregulated TAB1 and TLR4. In addition, SIRT7 knockdown significantly increased the phosphorylation of TAK1 and NF-κBp65 in LPS-treated DCMECs. Moreover, SIRT7 knockdown promoted the translocation of NF-κBp-p65 to the cell nucleus and then increased the secretion of inflammatory cytokines (IL-1β and IL-6). In contrast, SIRT7 overexpression had the opposite effects when compared to SIRT7 knockdown in LPS-treated DCMECs. In addition, SIRT7 overexpression attenuated LPS-induced DCMEC apoptosis. Taken together, our results indicate that SIRT7 can suppress LPS-induced inflammation and apoptosis via the NF-κB signaling pathway. Therefore, SIRT7 may be considered as a potential pharmacological target for clinical mastitis therapy.

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“…Given the nature of pterygium lesions, even when it is symptomatic, it usually generates at most irritation, itching or burning sensation, tearing, red eye or foreign body sensation, determining a mild eye pain [18][19]. Zidi et al have demonstrated that the clinical redness is significantly correlated with the chronic inflammatory response (P < 0.001) [1]. Signs of blurred vision appear when the lesion is significantly grown and it partially covers the cornea [20], obscuring the visual axis, or it may determine astigmatism [15].…”

Section: Resultsmentioning

confidence: 99%

“…To our knowledge, there are no similar studies, based on lesion sizes measured before surgery and associated symptoms, in order to correlate our findings. Zidi et al have searched for a connection between the extent of pterygium lesions and the chronic inflammatory response, identifying a reverse correlation between those two parameters, but did not perform a comparison between males and females [1]. In fact, UV light, which is one of the main factors in pterygium formation [21], induces a series of chronic inflammation cells within the conjunctiva.…”

Section: Resultsmentioning

confidence: 99%

“…Pter ygium has three components: the head that corresponds to the tip of the lesion, has a grey colour and it is not vascularized; the neck connects it to the body and presents neoformation and anastomotic blood vessels; the body represents the largest area, with multiple blood vessels that assure the lesion nutrition and presents a straight or a radial aspect, from the tip towards the body of the lesion. Pterygium may be composed by small atrophic lesions, or by large aggressive lesions, with a rapid fibrovascular progression, inflammatory infiltration (through the presence of Tlymphocytes), degraded extracellular matrix, that may alter the cornea structure and, in severe cases, lesions may even surround the optical centre of the cornea, inducing astigmatism [1][2].…”

mentioning

confidence: 99%

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Considerations Upon Pterygium Perception in Terms of Symptoms Induced by Inflammatory Response, According to Sex and Age

Mercut¹,

Crăiţoiu²,

Dima³

et al. 2019

Rev. Chim.

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Pterygium is a common eye disease, which affects both males and females, and is usually described by most patients as painless and unaesthetic. In case pterygium is symptomatic, the perceived ocular discomfort level is determined by a series of symptoms, among which we have studied tearing, foreign body sensation and blurred vision. Based on patients� evaluation, we have generated a perception score regrouping the presence or absence of symptoms, and we have analysed it according to various age decades and sex. In this study, our data revealed a correlation between the presence of the studied symptoms and the size of the lesion measured when patients opted for professional medical care (P [ 0.01). We have also determined that males and females with similar lesions in terms of size have a different perception upon pterygium; there are also differences regarding symptoms presence or absence, for various age decades and lifestyle context. In general, pterygium perception score indicated that males are more constant in their evaluation, presenting increased score values for higher ages; females tend to seek out medical treatment later than males, especially for higher ages, and present greater perception scores which do not seem to be correlated with age decades.

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Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium

Cited by 18 publications

References 43 publications

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

SIRT7 Regulates Lipopolysaccharide-Induced Inflammatory Injury by Suppressing the NF-κB Signaling Pathway

Considerations Upon Pterygium Perception in Terms of Symptoms Induced by Inflammatory Response, According to Sex and Age

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