Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs

Al-Mashhadi, Rozh H; Al-Mashhadi, Ahmed Ludvigsen; Nasr, Zahra; Mortensen, Martin Bødtker; Lewis, Esmeralda A; Camafeita, Emilio; Ravlo, Kristian; Al-Mashhadi, Zheer; Kjær, Daniel Willy; Palmfeldt, Johan; Bie, Peter; Jensen, Jesper Møller; Nørgaard, Bjarne Linde; Falk, Erling; Vázquez, Jesús; Bentzon, Jacob F.

doi:10.1016/j.jacc.2020.11.059

Cited by 20 publications

(8 citation statements)

References 28 publications

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“…A recent experimental study has suggested that high blood pressure per se exacerbates atherogenesis of coronary arteries in the absence of proatherogenic humoral factors 28 . In conditions without traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, and current smoking, the present study found that annualized dense calcium PVC was significantly lower in participants with normal SBP maintain than in those with ≥elevated SBP maintain .…”

Section: Discussionsupporting

confidence: 47%

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Won

Park

Heo

et al. 2022

Clinical Cardiology

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Background Atherosclerosis‐related adverse events are commonly observed even in conditions with low cardiovascular (CV) risk. Longitudinal data regarding the association of normal systolic blood pressure maintenance (SBPmaintain) with coronary plaque volume changes (PVC) has been limited in adults without traditional CV disease. Hypothesis Normal SBPmaintain is important to attenuate coronary atherosclerosis progression in adults without baseline CV disease. Methods We analyzed 95 adults (56.7 ± 8.5 years; 40.0% men) without baseline CV disease who underwent serial coronary computed tomographic angiography with mean 3.5 years of follow‐up. All participants were divided into two groups of normal SBPmaintain (follow‐up SBP < 120 mm Hg) and ≥elevated SBPmaintain (follow‐up SBP ≥ 120 mm Hg). Annualized PVC was defined as PVC divided by the interscan period. Results Compared to participants with normal SBPmaintain, those with ≥elevated SBPmaintain had higher annualized total PVC (mm3/year) (0.0 [0.0–2.2] vs. 4.1 [0.0–13.0]; p < .001). Baseline total plaque volume (β = .10) and the levels of SBPmaintain (β = .23) and follow‐up high‐density lipoprotein cholesterol (β = −0.28) were associated with annualized total PVC (all p < .05). The optimal cutoff of SBPmaintain for predicting plaque progression was 118.5 mm Hg (sensitivity: 78.2%, specificity: 62.5%; area under curve: 0.700; 95% confidence interval [CI]: 0.59–0.81; p < .05). SBPmaintain ≥ 118.5 mm Hg (odds ratio [OR]: 4.03; 95% CI: 1.51–10.75) and baseline total plaque volume (OR: 1.03; 95% CI: 1.01–1.06) independently influenced coronary plaque progression (all p < .05). Conclusion Normal SBPmaintain is substantial to attenuate coronary atherosclerosis progression in conditions without established CV disease.

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Section: Discussionsupporting

confidence: 47%

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Won

Park

Heo

et al. 2022

Clinical Cardiology

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show abstract

“…Despite being a well-established independent risk factor for atherosclerosis, the mechanism by which hypertension accelerates CAD has remained elusive. A recent study shed light on this important issue by demonstrating that increased pressure per se facilitates coronary atherosclerosis, independent of humoral changes associated with hypertension, by increasing smooth muscle cell activity and intimal accumulation of LDLs (Al-Mashhadi et al, 2021).…”

Section: Hypertensionmentioning

confidence: 99%

Atherosclerosis: Recent developments

Björkegren

Lusis

2022

Cell

469

248

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“…Thus the high risk may due to the effects of elevated blood pressure on the progression of atherosclerosis. 28 , 29 , 30 Secondly, high SBP is a predictor of ulceration of carotid plaques which are associated with a high risk of ischemic stroke. 31 Thirdly, since the etiological diagnosis for non‐lacunar infarction in this subgroup study was mainly artery to artery embolic strokes, multiple acute cerebral infarcts in non‐lacunar infarction may indicate an unstable source of thromboembolism.…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, baseline high blood pressure might be an indicator of the previous history of hypertension. Thus the high risk may due to the effects of elevated blood pressure on the progression of atherosclerosis 28–30 . Secondly, high SBP is a predictor of ulceration of carotid plaques which are associated with a high risk of ischemic stroke 31 .…”

Section: Discussionmentioning

confidence: 99%

Systolic blood pressure and recurrent stroke in patients with different lesion patterns on diffusion weighted imaging

Chen

Xie

et al. 2022

J of Clinical Hypertension

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Little is known about the relationship between baseline systolic blood pressure (SBP) and subsequent clinical events in patients with different lesion patterns on diffusion weighted imaging (DWI). We analyzed the Acute Non-disabling Cerebrovascular Events (CHANCE) trial dataset. Patients were categorized into negative DW imaging (no detectable lesions), lacunar infarction (single lesion ≤15 mm) and nonlacunar infarction (single lesion >15 mm or multiple lesions) based on lesion patterns on DWI. The primary outcome was recurrent stroke within 90 days. Cox proportional hazards models were used to assess the association between SBP levels and stroke outcomes in patients with different lesion patterns. A total of 1089 patients were analyzed. We found 258 cases (23.7%) with negative DW imaging, 392 (36.0%) with lacunar infarction and 439 (40.3%) with non-lacunar infarction. Patients with non-lacunar infarction had the highest incidence of stroke at 90-day (P < .001).In non-lacunar infarction group, compared with SBP < 160 mmHg, patients with SBP ≥ 160 mmHg had significantly higher risk of 90-day recurrent stroke (20.3% vs. 10.7%; adjusted hazard ratio 1.81, 95% confidence interval 1.09-3.00). No significant association was found between SBP and clinical outcomes in patients with negative DWI and lacunar stroke groups. The result at 1 year was similar as at 90-day. Therefore, non-lacunar infarction, the most common lesion pattern in CHANCE study, had the highest risk of recurrent stroke and combined vascular events both in 90 days and Pan Chen and Qiong Wu contributed equally.

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Local Pressure Drives Low-Density Lipoprotein Accumulation and Coronary Atherosclerosis in Hypertensive Minipigs

Cited by 20 publications

References 28 publications

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Longitudinal quantitative assessment of coronary atherosclerosis related to normal systolic blood pressure maintenance in the absence of established cardiovascular disease

Atherosclerosis: Recent developments

Systolic blood pressure and recurrent stroke in patients with different lesion patterns on diffusion weighted imaging

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