Local Plasticity of Dendritic Excitability Can Be Autonomous of Synaptic Plasticity and Regulated by Activity-Based Phosphorylation of Kv4.2

Labno, Anna; Warrier, Ajithkumar; Wang, Sheng; Zhang, Xiang

doi:10.1371/journal.pone.0084086

Cited by 11 publications

(11 citation statements)

References 53 publications

(54 reference statements)

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“…In contrast, we found neuronal excitability, but not excitatory synaptic physiology, to be altered by devaluation. In line with our findings, previous studies have reported excitability changes independently of synaptic plasticity (Egorov et al, 2002; Labno et al, 2014). It is proposed that alterations in excitability may serve as a transient priming mechanism for initial associative memory formation before synaptic changes take place (Moyer et al, 1996; Janowitz and Van Rossum, 2006; Mozzachiodi and Byrne, 2010).…”

Section: Discussionsupporting

confidence: 93%

Reward Devaluation Attenuates Cue-Evoked Sucrose Seeking and Is Associated with the Elimination of Excitability Differences between Ensemble and Non-ensemble Neurons in the Nucleus Accumbens

Sieburg

Ziminski

Margetts-Smith

et al. 2019

eNeuro

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Animals must learn relationships between foods and the environmental cues that predict their availability for survival. Such cue-food associations are encoded in sparse sets of neurons or "neuronal ensembles" in the nucleus accumbens (NAc). For these ensemble-encoded, cue-controlled appetitive responses to remain adaptive, they must allow for their dynamic updating depending on acute changes in internal states such as physiological hunger or the perceived desirability of food. However, how these neuronal ensembles are recruited and physiologically modified following the update of such learned associations is unclear. To investigate this, we examined the effects of devaluation on ensemble plasticity at the levels of recruitment, intrinsic excitability, and synaptic physiology in sucrose-conditioned Fos-GFP mice that express green fluorescent protein (GFP) in recently activated neurons. Neuronal ensemble activation patterns and their physiology were examined using immunohistochemistry and slice electrophysiology, respectively. Reward-specific devaluation following 4 d of ad libitum sucrose consumption, but not general caloric devaluation, attenuated cue-evoked sucrose seeking. This suggests that changes in the hedonic and/or incentive value of sucrose, and not caloric need, drove this behavior. Moreover, devaluation attenuated the size of the neuronal ensemble recruited by the cue in the NAc shell. Finally, it eliminated the relative enhanced excitability of ensemble (GFP ϩ) neurons against non-ensemble (GFP Ϫ) neurons New Research

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Section: Discussionsupporting

confidence: 93%

Reward Devaluation Attenuates Cue-Evoked Sucrose Seeking and Is Associated with the Elimination of Excitability Differences between Ensemble and Non-ensemble Neurons in the Nucleus Accumbens

Sieburg

Ziminski

Margetts-Smith

et al. 2019

eNeuro

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“…This confirms a similar finding on the effect of global CaMKII overexpression (thus increasing CaMKII*) on fear conditioning, see (Cao et al, 2008; Wang et al, 2003). On any simple model, such memory deficits would not be expected if processes unrelated to CaMKII stored memory, as proposed by (Murakoshi et al, 2017); in this case, such processes could serve as a basis of memory recall even when CaMKII-dependent effects on synapses or other cellular properties (Fan et al, 2005; Labno et al, 2014; Sametsky et al, 2009) were saturated.…”

Section: Discussionmentioning

confidence: 98%

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage

Rossetti

Banerjee

Kim

et al. 2017

Neuron

121

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Summary The abundant synaptic protein, CaMKII, is necessary for long-term potentiation (LTP) and memory. However, whether CaMKII is required only during initial processes or whether it also mediates memory storage remains unclear. The most direct test of a storage role is the erasure test. In this test, a putative memory molecule is transiently inhibited after learning. The key prediction is that this should produce persistent memory erasure. We conducted this test using transient viral (HSV) expression of dominant-negative CaMKII-alpha (K42M) in the hippocampus. This produced persistent erasure of conditioned place avoidance. As an additional test, we found that expression of activated CaMKII (T286D/T305A/T306A) impaired place avoidance, a result not expected if a process other than CaMKII stores memory. Our behavioral results, taken together with prior experiments on LTP, strongly support a critical role of CaMKII in LTP maintenance and memory storage.

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“…Expressed in the dendritic spines of the post-synaptic density (PSD) [39,40], this protein is an actin-crosslinking protein [41] that is involved with synaptic plasticity [39]. This is interesting because changes in dendrite activity might be related to synaptic plasticity [42,43].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Mouse Brain Subjected to Spaceflight

Mao

Sandberg

Gridley

et al. 2018

IJMS

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There is evidence that spaceflight poses acute and late risks to the central nervous system. To explore possible mechanisms, the proteomic changes following spaceflight in mouse brain were characterized. Space Shuttle Atlantis (STS-135) was launched from the Kennedy Space Center (KSC) on a 13-day mission. Within 3–5 h after landing, brain tissue was collected to evaluate protein expression profiles using quantitative proteomic analysis. Our results showed that there were 26 proteins that were significantly altered after spaceflight in the gray and/or white matter. While there was no overlap between the white and gray matter in terms of individual proteins, there was overlap in terms of function, synaptic plasticity, vesical activity, protein/organelle transport, and metabolism. Our data demonstrate that exposure to the spaceflight environment induces significant changes in protein expression related to neuronal structure and metabolic function. This might lead to a significant impact on brain structural and functional integrity that could affect the outcome of space missions.

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Local Plasticity of Dendritic Excitability Can Be Autonomous of Synaptic Plasticity and Regulated by Activity-Based Phosphorylation of Kv4.2

Cited by 11 publications

References 53 publications

Reward Devaluation Attenuates Cue-Evoked Sucrose Seeking and Is Associated with the Elimination of Excitability Differences between Ensemble and Non-ensemble Neurons in the Nucleus Accumbens

Reward Devaluation Attenuates Cue-Evoked Sucrose Seeking and Is Associated with the Elimination of Excitability Differences between Ensemble and Non-ensemble Neurons in the Nucleus Accumbens

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage

Proteomic Analysis of Mouse Brain Subjected to Spaceflight

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