Local plants as potential sources of tannins in Egypt. Part VII (Rubiaceae to Vitaceae)

Sherbeiny, A. E. A. El; Saleh, Nabiel A.M.; Sissi, H. I. El

doi:10.1007/bf01104907

Cited by 5 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aerial parts were used as central nerves system (CNS) depressant, hypothermic and semen coagulant activity [2]. Literature survey revealed little information concerning the chemical constituents, Saleh et al [3] reported the possible presence of tannins in the plant leaves. Mohammed [4] reported the isolation of D-mannitol from I. undulata leaves, which was reported to ameliorate some metabolic disorders in schistosomal mansoni infected mice [5].…”

Section: Introductionmentioning

confidence: 99%

Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. Leaves

Mohammed¹

2014

Nat Prod Chem Res

View full text Add to dashboard Cite

Leaves of Ixora undulata Roxb. were investigated phytochemically for the first time for its alkaloidal content, which resulted in the isolation of a novel unusual thiazepine alkaloid glycoside identified as 7-[(β-D-glucopyranosyl)oxy]-6-hydroxy-2-methoxy-4,5-dihydro-1,3-thiazepine and trivially named as Rubiothiazepine. Its structure was determined on the basis of 1D and 2D NMR ( 1 H-, 13 C-NMR, 1 H-1 H COSY, 1 H-13 C HETCOR, 1 H-13 C HMBC, 1 H-15 N HMBC and DIFNOE), high resolution ESI-CID-MS/MS, UV and IR spectroscopy. The isolated compound showed cytotoxic activity against EL 4 (Murine Leukemia) with IC 50 >100 µg/mL, and also showed cytotoxic and HIV-1 activity against MT-4 and HIV-1IIIB with CC 50 >100 µg/mL and EC 50 >100 µg/mL, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%