1950
DOI: 10.1136/adc.25.121.1
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Local Paralysis in Children after Injections

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Cited by 51 publications
(3 citation statements)
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References 11 publications
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“…Bodian, 1952). But when it was recognized that localized paralysis in poliomyelitis was sometimes precipitated by injections of diphtheria prophylactics and the like (Martin, 1950;McCloskey, 1950) it was suggested that a reflex mechanism might in some way predispose to a local invasion of the nervous system from the blood-stream (Burnet, 1950). That such localized reflexes occurred was shown by Field, Grayson & Rogers (1949.…”
Section: Printed In Great Britainmentioning
confidence: 99%
“…Bodian, 1952). But when it was recognized that localized paralysis in poliomyelitis was sometimes precipitated by injections of diphtheria prophylactics and the like (Martin, 1950;McCloskey, 1950) it was suggested that a reflex mechanism might in some way predispose to a local invasion of the nervous system from the blood-stream (Burnet, 1950). That such localized reflexes occurred was shown by Field, Grayson & Rogers (1949.…”
Section: Printed In Great Britainmentioning
confidence: 99%
“…'6 These reports were based on observations made in one or several cases. During 1950 a number of British and Australian investigators reported on studies in groups of cases [17][18][19][20][21][22][23] which indicated that in children recently inoculated with pertussis vaccine, diphtheria toxoid, or tetanus toxoid the injected limb was more frequently the site of paralysis than was the case in children not recently inoculated. Hill and Knowelden,24 in a careful statistical study, corroborated these findings.…”
mentioning
confidence: 99%
“…When diphtheria and pertussis vaccines were introduced in the 1940s, cases of paralytic poliomyelitis skyrocketed ( Figure 1) [10]. This was documented in Lancet and other medical journals [11][12][13]. In 1949, the Medical Research Council in Great Britain set up a committee to investigate the matter and ultimately concluded that individuals are at increased risk of paralysis for 30 days following injections; injections alter the distribution of paralysis; and it did not matter whether the injections were subcutaneous or intramuscular [14,15].…”
mentioning
confidence: 99%