Local Nasal Response Against COVID-19: Debate Regarding the Absence of Nasal Inflammatory Symptoms

Sayın, İbrahim; Yazıcı, Zahide Mine; Akgül, Ahmet

doi:10.1177/0145561321992505

Ear Nose Throat J

2021

DOI: 10.1177/0145561321992505

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Local Nasal Response Against COVID-19: Debate Regarding the Absence of Nasal Inflammatory Symptoms

İbrahim Sayın

Zahide Mine Yazıcı

Ahmet Akgül

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Cited by 3 publications

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“…We read with interest the article by Sayin et al, debating the significance of the paucity of nasal symptomatology, except for anosmia, in COVID-19. 1 However, the authors didn’t provide any pathophysiological mechanism for this low incidence of sneezing, rhinorrhea, nasal obstruction, and sinusitis-like manifestations of the usual viral rhinitis in COVID-19. We, herein, take an opportunity to explain these differences based on our “epithelial-endothelial cross-talk hypothesis” of COVID-19 pneumonia.…”

mentioning

confidence: 99%

Upregulation of ACE/ACE2 Balance in Nasal Mucosa: A Working Hypothesis to Explain the Absence of Nasal Inflammatory Symptoms in COVID-19 Disease

Jain¹,

Lamperti²

2021

Ear Nose Throat J

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mentioning

confidence: 99%

Upregulation of ACE/ACE2 Balance in Nasal Mucosa: A Working Hypothesis to Explain the Absence of Nasal Inflammatory Symptoms in COVID-19 Disease

Jain¹,

Lamperti²

2021

Ear Nose Throat J

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Could smell and taste dysfunction in COVID-19 patients be a sign of the clinical course of the disease?

Bayrak

Karaca

Özkul

2021

Egypt J Otolaryngol

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Background It could be of great benefit to determine smell and taste dysfunction in COVID-19 patients and to investigate the relationship between these symptoms and clinical characteristics as the determination of points requiring attention during the clinical course of the disease. Method Evaluations of patients diagnosed with COVID-19 were made using a questionnaire method. Those with smell and taste dysfunction completed a visual analog scale (VAS) to determine severity. The patients were evaluated at the end of 1 and 2 months. Results Evaluation was made of a total of 105 patients with a mean age of 55.9±17.6 years. Smell and taste dysfunction was present in 56 (53.3%) patients with a mean age of 48.7±17.6 years and the 49 (46.7%) patients with no smell and taste dysfunction had a mean age of 64±13.6 years. It was determined that as age increased, the complaints of smell and taste dysfunction decreased. Full recovery was determined in 31 (55%) patients after 1 month, and in 16 (28%) patients, smell and taste dysfunction continued at the end of the second month. The symptoms of smell and taste dysfunction were determined to last longer in patients with no comorbidities, no symptoms of fever or shortness of breath, and those treated as outpatients (p=0.043, p=0.031, p=0.034, p=0.028, respectively). In the older age patient group, the VAS scores were observed to be higher and the time to recovery was shorter (p=0.007, p=0.018, respectively). Conclusion Smell and taste dysfunction in COVID-19 patients is seen more as age decreases and recovery takes longer. Smell and taste dysfunction is seen more in patients with symptoms of cough, nasal obstruction, and headache and lasts longer in patients without symptoms of fever and shortness of breath, with no comorbidities and in those treated as outpatients.

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Smell and Taste Impairment in COVID-19 Positive Pediatric Patients: A Prospective Cohort on Different Stages of The Disease

Yazıcı¹,

Sağlam²,

Akçay³

et al. 2022

BMB

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Local Nasal Response Against COVID-19: Debate Regarding the Absence of Nasal Inflammatory Symptoms

Cited by 3 publications

References 12 publications

Upregulation of ACE/ACE2 Balance in Nasal Mucosa: A Working Hypothesis to Explain the Absence of Nasal Inflammatory Symptoms in COVID-19 Disease

Upregulation of ACE/ACE2 Balance in Nasal Mucosa: A Working Hypothesis to Explain the Absence of Nasal Inflammatory Symptoms in COVID-19 Disease

Could smell and taste dysfunction in COVID-19 patients be a sign of the clinical course of the disease?

Smell and Taste Impairment in COVID-19 Positive Pediatric Patients: A Prospective Cohort on Different Stages of The Disease

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