Local nasal immunotherapy for birch allergic rhinitis with extract in powder form

Andri, L; Senna, Gianenrico; Andri, G; Dama, Annarita; Givanni, S; Betteli, C.; Dimitri, Gabriella; Falagiani, P.; Mezzelani, Paolo

doi:10.1111/j.1365-2222.1995.tb03256.x

Cited by 45 publications

(30 citation statements)

References 25 publications

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“…So far, 21 studies are available for LNIT, and 14 of them were properly performed (43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56), Of these, 13 report a significant improvement of rhinitic symptoms. Furthermore, a reduction of the nasal reactivity and local immunologic response was found in some studies, while systemic immunologic changes were usually absent or equivocal: this may suggest that LNIT exerts its actions only on the target organ.…”

Section: Experimental Evidence: Clinical Efficacymentioning

confidence: 99%

Local immunotherapy: pharmacokinetics and efficacy

Passalacqua

Bagnasco

Mariani

et al. 1998

Allergy

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Section: Experimental Evidence: Clinical Efficacymentioning

confidence: 99%

Local immunotherapy: pharmacokinetics and efficacy

Passalacqua

Bagnasco

Mariani

et al. 1998

Allergy

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“…Allergen-specific IT is the only treatment recognized to be effective. It has been shown to prevent new sensitization, and the clinical efficacy of various specific nasal ITs has been documented either using aqueous extract (22,23) or extract in powder form (26,27). However, persistent local reaction and technical difficulty limit its application.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Local Nasal Immunotherapy in Allergic Rhinitis: Using Strips of the AllergenDermatophagoides pteronyssinus

et al. 2009

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Local nasal immunotherapy (LNIT) has been reported to be effective for mite-induced allergic rhinitis. However, its compliance is poor due to persistent nasal reactions and difficult application. The main objective of this study was to develop a Dermatophagoides pteronyssinus (Der p)-coated strip for self-application and to evaluate its clinical efficacy. Randomized, double-blind, placebo-controlled trials were carried out to evaluate the efficacy and compliance of LNIT. A total of 35 patients with allergic rhinitis from the allergy clinic were recruited to receive four months of LNIT. Clinical efficacy was evaluated by the symptoms of sneezing, rhinorrhea and nasal stuffiness. Local and systemic effects were evaluated by measuring histamine and eosinophil cationic protein (ECP) in nasal discharge and allergen-specific IgG1, IgG4 and IgE in sera. LNIT with Der p-coated strips could reduce nasal symptoms and modulate the serum levels of Der p-specific IgG1, IgG4 and IgE. The secretion of both histamine and ECP was reduced within four months after treatment. When the symptomatic and immunological changes were compared between active treatment and placebo groups, the improvements were greater in the active treatment groups for all three symptom scores. There were no severe adverse events except nasal response persisting within the first month in some cases. LNIT with a steady dose of Der p-coated strips can be self-administered at home without any systemic reactions. Both local and systemic immune responses were observed after LNIT. This therapeutic modality may serve as a good alternative treatment for allergic rhinitis.

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“…Four studies (312)(313)(314)(315) could not be used because of methodological limitations (Table 12). Thirteen out of 14 studies found a significant improvement of nasal symptoms both in perennial (1 study) and seasonal allergic rhinitis (12 studies) (316)(317)(318)(319)(320)(321)(322)(323)(324)(325)(326)(327)(328)(329). In general, the effectiveness of nasal immunotherapy seems to be dose-related, and clinical improvement appears to have been greater with aqueous and powdered vaccines than with modified ones.…”

Section: Nasal Routementioning

confidence: 99%