Local Interferon-Alpha2b is Not an Effective Treatment in Early-Stage Peyronie's Disease

Wegner, H; Andresen, Reimer; Knispel, Helmut H.; Miller, Kurt

doi:10.1097/00005392-199805000-00132

Cited by 20 publications

(28 citation statements)

References 2 publications

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“…27 In an other study by Wegner et al, the curvature improved only in 3.3% while remaining stable in 86.7% after local injections of INF-a2b, which is proposed to alter metabolic activities of myo®broblasts. 28 However, they also underlined the controversies about local INF-a2b therapy since the disease is not limited to the initial plaque site. 28 The search for a`tablet' cure, has put pressure on the investigators and by the mid-twentieth century, oral vitamin E, estrogens and procarbazine joined the treatment armoury.…”

Section: Discussionmentioning

confidence: 99%

“…28 However, they also underlined the controversies about local INF-a2b therapy since the disease is not limited to the initial plaque site. 28 The search for a`tablet' cure, has put pressure on the investigators and by the mid-twentieth century, oral vitamin E, estrogens and procarbazine joined the treatment armoury. 18 However, these agents deemed to be of limited ef®ciency with severe side-effects, except vitamin E, and the lack of control data was highlighted.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

et al. 2000

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“…They ultimately concluded that intralesional therapy with IFN-a-2b was not effective. 28 However, this study appears to present a surgical bias and lacks the inclusion of a placebo control group.…”

Section: Figure 1 Demonstration Of Ifn-a-2b Injected Directly Into Amentioning

confidence: 98%

Intralesional interferon-alpha-2b for the treatment of Peyronie's disease

Lacy

Adams

2002

Int J Impot Res

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Peyronie's disease can best be described as a localized connective tissue disorder that primarily affects the tunica albuginea of the penis. The disease may be attributed to repetitive vascular trauma that initiates an inflammatory process and ultimately leads to the formation of a fibrous penile plaque. The plaque consists mainly of collagen and can significantly alter penile anatomy and function. Patients with Peyronie's disease will most often present with penile curvature, pain on erection, a palpable nodule most commonly located on the dorsal shaft of the penis, and erectile dysfunction. There is no definitive treatment for Peyronie's disease and the treating physician has many options. They may wait for spontaneous resolution of the plaque, choose medical therapy (which includes both oral and intralesional regimens), or opt for surgical management. The main purpose of this article is to discuss the advances in medical therapy for Peyronie's disease, in particular intralesional injection of interferon-alpha-2b (IFN-a-2b). Several studies have concluded that IFN-a-2b can be an effective modality of treatment and that many patients placed on a regimen of IFN-a-2b experienced a significant reduction in penile curvature, diminished pain with erection, and decreased size of the plaque. Further clinical studies are currently being undertaken to determine the precise quantity and frequency of administration of IFN-a-2b that is most effective with the least amount of side effects.

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“…Pain resolution was observed in 67% of the treatment group versus 28% in the placebo group. Wegner et al [26] demonstrated low rates of improvement and a high incidence of side effects, including myalgia and fever. Limited improvements in curvature observed in these studies are unlikely to have a significant clinical benefit and therefore intralesional IFN is currently not recommended as a treatment for PD.…”

Section: Intralesional Interferonmentioning

confidence: 99%

Nonsurgical treatment options in Peyronie’s Disease: 2016 update

Talib

Ibrahim

Cangüven

2016

Turkish Journal of Urology

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Peyronie's disease (PD) is an inflammatory condition of penile tunica albuginea which commonly ends with penile curvature and difficulty in vaginal penetration. Unfortunately, the pathophysiology of PD has not been completely understood. In this paper, we will review what is known about the pathophysiology of PD and the nonsurgical medical treatment options that have been trialed as a result. In the last 5 years, commonly used oral medications left their places to intralesional therapies. Clostridium collagenase, which is the only Food and Drug Administration (FDA) approved treatment for PD, is now the most prescribed intralesional therapy in the last years. Clostridium collagenase is advised for patients whose penile curvature is > 30° and < 90°. Because of its side effects, patients should be counseled before intralesional Clostridium collagenase treatment. Until finding best treatment solution for PD, more investigations in regards to the basic science of PD need to be carried out in order to elucidate the exact mechanisms of the fibrosis.

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Local Interferon-Alpha2b is Not an Effective Treatment in Early-Stage Peyronie's Disease

Cited by 20 publications

References 2 publications

Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

Intralesional interferon-alpha-2b for the treatment of Peyronie's disease

Nonsurgical treatment options in Peyronie’s Disease: 2016 update

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