Local infusion of ghrelin into the lateral amygdala blocks extinction of conditioned taste aversion in rats

Ge, Song; Zhu, Qianqian; Han, Fubing; Liu, Shuai; Zhao, Chenyang; Zhou, Yu

doi:10.1016/j.neulet.2017.10.012

Cited by 11 publications

(2 citation statements)

References 28 publications

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“…Ghrelin administration attenuates CFA induced by lithium chloride, at least in part, by acting specifically in the lateral amygdala in rats. For example, while ip injection of the GHSR antagonist JMV2959 alone has no impact on CFA [132], infusion of ghrelin directly in the lateral amygdala prevents the acquisition of a lithium chloride-induced CFA in a GHSRdependent manner [133,134] but also its extinction [135]. In addition, GHSR signaling may provide an avenue to reduce food intake without promoting CFA as treatment with novel GHSR inverse agonists inhibits standard chow intake without promoting CFA in mice [136].…”

Section: Rodent Studiesmentioning

confidence: 99%

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

Décarie-Spain

Kanoski

2021

Nutrients

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Eating behaviors are influenced by the reinforcing properties of foods that can favor decisions driven by reward incentives over metabolic needs. These food reward-motivated behaviors are modulated by gut-derived peptides such as ghrelin and glucagon-like peptide-1 (GLP-1) that are well-established to promote or reduce energy intake, respectively. In this review we highlight the antagonizing actions of ghrelin and GLP-1 on various behavioral constructs related to food reward/reinforcement, including reactivity to food cues, conditioned meal anticipation, effort-based food-motivated behaviors, and flavor-nutrient preference and aversion learning. We integrate physiological and behavioral neuroscience studies conducted in both rodents and human to illustrate translational findings of interest for the treatment of obesity or metabolic impairments. Collectively, the literature discussed herein highlights a model where ghrelin and GLP-1 regulate food reward-motivated behaviors via both competing and independent neurobiological and behavioral mechanisms.

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Section: Rodent Studiesmentioning

confidence: 99%

Ghrelin and Glucagon-Like Peptide-1: A Gut-Brain Axis Battle for Food Reward

Décarie-Spain

Kanoski

2021

Nutrients

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“…Using GHS‐R1a agonists and antagonists, it was shown that receptor activation leads to changes in many cascades of intracellular reactions (see Figure 1 ). These intracellular pathways appear to be specific for a certain region of the brain and probably depend on the metabolic or stress status of the individual, as well as on the microenvironment, which contains various signaling molecules (Guo et al, 2019 ; Song et al, 2018 ).…”

Section: Ghs‐r1a In the Brainmentioning

confidence: 99%

Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain

Айрапетов

Ереско

Лебедев

et al. 2021

Physiological Reports

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The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of the receptor in many physiological processes. Using various organisms, data have been obtained regarding the participation of the GHS‐R1a in the regulation of the anti‐ and pro‐inflammatory response, proliferation, and apoptosis. It is known that the receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of drug addiction, obesity, and chronic alcohol consumption. Based on this, research is underway with the use of various therapeutic agents that can be used for the pharmacological correction of these conditions. This review also presents hypothetical pathways of intracellular signaling, in which GHS‐R1a may participate. A complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular signaling seem to be specific to brain region and, probably, also depend on the metabolic or stress status of the organism.

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