Local inflammatory response induced by scorpionfish Scorpaena plumieri venom in mice

Menezes, Thiago N.; Carnielli, Juliana B.T.; Gomes, Helena L.; Pereira, Fausto Edmundo Lima; Lemos, Elenice Moreira; Bissoli, Nazaré Souza; Lopes-Ferreira, Mônica; Andrich, Filipe; Figueiredo, Suely G.

doi:10.1016/j.toxicon.2012.03.008

Cited by 16 publications

(9 citation statements)

References 35 publications

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“…As with nociceptive activity, kinins were indicated in playing a major role in the inflammatory process of T. nattereri [ 112 ]. The kallikrein-kinin pathway was also implicated in the inflammatory action brought on by injection of S. plumieri venom in mice, although venom did not cause a direct release of kinin [ 113 ]. However, the venom of the toadfish Porichthys porosissimus caused an inflammatory response that involved the more classic cellular recruitment of neutrophils that proceeded macrophages and rolling leukocytes [ 110 ].…”

Section: Venom Activitiesmentioning

confidence: 99%

Bioactive Components in Fish Venoms

Ziegman

Alewood

2015

Toxins

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Animal venoms are widely recognized excellent resources for the discovery of novel drug leads and physiological tools. Most are comprised of a large number of components, of which the enzymes, small peptides, and proteins are studied for their important bioactivities. However, in spite of there being over 2000 venomous fish species, piscine venoms have been relatively underrepresented in the literature thus far. Most studies have explored whole or partially fractioned venom, revealing broad pharmacology, which includes cardiovascular, neuromuscular, cytotoxic, inflammatory, and nociceptive activities. Several large proteinaceous toxins, such as stonustoxin, verrucotoxin, and Sp-CTx, have been isolated from scorpaenoid fish. These form pores in cell membranes, resulting in cell death and creating a cascade of reactions that result in many, but not all, of the physiological symptoms observed from envenomation. Additionally, Natterins, a novel family of toxins possessing kininogenase activity have been found in toadfish venom. A variety of smaller protein toxins, as well as a small number of peptides, enzymes, and non-proteinaceous molecules have also been isolated from a range of fish venoms, but most remain poorly characterized. Many other bioactive fish venom components remain to be discovered and investigated. These represent an untapped treasure of potentially useful molecules.

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Section: Venom Activitiesmentioning

confidence: 99%

Bioactive Components in Fish Venoms

Ziegman

Alewood

2015

Toxins

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“…Increased cytokines levels during the acute stage have been described by several authors in accidents involving venomous animals [4,33,[40][41][42]. Studies involving scorpion venom demonstrated a positive physiopathological correlation between cytokine concentrations and severity of clinical manifestations [43][44][45][46] Systemic toxicity is markedly affected by cytokines release.…”

Section: Discussionmentioning

confidence: 97%

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Azevêdo

Figueiredo

Pinto³

et al. 2020

PLoS ONE

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This study investigated the systemic inflammatory response and mechanism of pulmonary lesions induced by Crotalus durissus cascavella venom in murine in the state of Bahia. In order to investigate T helper Th1, Th2 and Th17 lymphocyte profiles, we measured interleukin (IL) -2, IL-4, IL-6, IL-10, IL-17, tumor necrosis factor (TNF) and interferon gamma (IFN-γ) levels in the peritoneal fluid and macerated lungs of mice and histopathological alterations at the specific time windows of 1h, 3h, 6h, 12h, 24h and 48h after inoculation with Crotalus durissus cascavella venom. The data demonstrated an increase of acute-phase cytokines (IL-6 and TNF) in the first hours after inoculation, with a subsequent increase in IL-10 and IL-4, suggesting immune response modulation for the Th2 profile. The histopathological analysis showed significant morphological alterations, compatible with acute pulmonary lesions, with polymorphonuclear leukocyte (PMN) infiltration, intra-alveolar edema, congestion, hemorrhage and atelectasis. These findings advance our understanding of the dynamics of envenomation and contribute to improve clinical management and antiophidic therapy for individuals exposed to venom.

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“…Interleukin-6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and interleukin-10 (IL-10) were simultaneously quantified using the Cytometric Bead Array Mouse commercial kit (BD Biosciences, San Diego, CA, USA) in agreement with the description by Menezes et al (2012). The analysis was made by flow cytometry using the animal's plasma.…”

Section: Quantification Of Pro-and Anti-inflammatory Cytokinesmentioning

confidence: 99%

Reduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage Apoptosis

Filete¹,

Moraes²,

Brasil³

et al. 2019

OnLine Journal of Biological Sciences

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Atherosclerosis is among the major cardiovascular diseases that cause death in the world. Men who are deficient in androgen hormones are more susceptible to this disease. The aim of this study was to evaluate the influence of reduced levels of testosterone on the lipid profile, pro and anti-inflammatory cytokines, apoptosis of peritoneal macrophages and the development of atherosclerosis in LDLr-/-mice, as well as on the levels of OxLDL in healthy male humans. Tissues and organs of the experimental animals were used to evaluate lipid deposition in aorta and apoptosis of peritoneal macrophages. In humans the levels of testosterone and OxLDL were analyzed in blood samples from healthy male subjects, who were divided into two groups: low level and high level of testosterone. Animals with decreased testosterone did not present changes in the lipid profile or the levels of IL-6 and TNF-α. However, a decrease in IL-10 and an increase in the IL-6/IL-10 and TNF-α/IL-10 ratios were observed. An increase in the aorta lipid deposition was observed and a decrease in macrophage apoptosis was also demonstrated. In humans, there was an increase of OxLDL in the group with lower levels of testosterone. The findings suggest that decreasing endogenous testosterone levels may induce the development of atherosclerosis, with participation of inflammatory response and macrophage apoptosis. This is reinforced by our human studies, where individuals with low testosterone levels had higher LDL oxidation, which may predict a high atherosclerotic risk for these men.

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Local inflammatory response induced by scorpionfish Scorpaena plumieri venom in mice

Cited by 16 publications

References 35 publications

Bioactive Components in Fish Venoms

Bioactive Components in Fish Venoms

Evaluation of systemic inflammatory response and lung injury induced by Crotalus durissus cascavella venom

Reduced Levels of Testosterone Induce LDL Oxidation and Atherosclerotic Lesions Involving Inflammatory Imbalance and Reduced Macrophage Apoptosis

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