Local infectious complications in cardiac surgery: etiology and the role of antimicrobial prophylaxis

Stepin, A.V.

doi:10.17116/hirurgia202206140

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…In our analysis of causative microorganisms and another study [ 31 ], Gram-negative bacteria emerged as predominant, representing 54% of all causes of infection. However, in a study focusing on local infectious complications of heart surgery the predominance of Gram-positive cocci was observed [ 32 ]. Fungal infections following MHS are much less common.…”

Section: Discussionmentioning

confidence: 99%

Infectious complications following major heart surgery from the day of the surgery to hospital discharge

Pérez-Granda,

Barrio,

Cuerpo

et al. 2024

BMC Infect Dis

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Background At some point in their lives, many people will require major heart surgery (MHS). Patients are generally older adults with various risk factors for infection. However, the incidence of infection after MHS is poorly known, as reported infection data are frequently biased due to different factors like the surgical procedure, postoperative timing, and infectious syndromes or etiologic agents, among others. In addition, most patient data are retrospectively obtained. Purpose and methods Data were prospectively collected regarding the incidence of all nosocomial infections produced from the time of surgery to hospital discharge in a cohort of 800 adults consecutively undergoing a MHS procedure. Results During postoperative hospitalization, 124 of the 800 participants developed one or more infections (15.5%): during their ICU stay in 68 patients (54.8%), during their stay on the general ward post ICU in 50 (40.3%), and during their stay in both wards in 6 (4.8%). The most common infections were pneumonia (related or not to mechanical ventilation), surgical site and bloodstream. As etiological agents, 193 pathogens were isolated: mostly Gram-negative bacilli (54.4%), followed by Gram-positive bacteria (30%), viruses (4.6%) and fungi (1.5%). In our cohort, all-cause mortality was recorded in 33 participants (4.1%) and 9 infection-related deaths (1.1%) were produced. Among subjects who developed infections, overall mortality was 13.7% and in those who did not, this was only 2.3%. Conclusion Infection following MHS remains frequent and severe. Our data suggest that hospital-acquired infection studies should consider episodes of infection in all populations during their entire hospital stay and not only those related to specific clinical syndromes or acquired while the patient is in intensive care.

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Section: Discussionmentioning

confidence: 99%