Local Inductive Heating Method Using Novel High-Temperature Implant for Thermal Treatment of Luminal Organs

Kotsuka, Youji; Kayahara, H.; Murano, Kimitoshi; Matsui, Hiroko; Hamuro, Masao

doi:10.1109/tmtt.2009.2029743

Cited by 10 publications

(13 citation statements)

References 16 publications

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“…This is an implanted device with which treatment can be done multiple times once the implant is in place, which may make it useful in the treatment of large or recurrent tumours. The technique used in this thermal ablation device also has the advantage that it can be applied to implants of various shapes, including stent-like and plate implants [14]. In addition to ablation treatment, it may also be possible to use the device in heat therapy for hollow viscera or blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Development of a highly efficient implanted thermal ablation device:in vivoexperiment in rat liver

Matsui

Hamuro²,

Nakamura³

et al. 2012

BJR

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Objectives: To evaluate an implanted thermal ablation device that can be heated with high efficiency using a resonant circuit as the implant. Methods: 16 rats were used. The implants, adjusted at a resonance frequency of 4 MHz, were fixed on the surface of the liver of rats under laparotomy. In 14 of 16 rats, an alternating magnetic field (AMF) was applied for 6 min with an output of 300 W from outside the body using a ferrite core applicator. The implant temperature during AMF exposure was measured. The 14 rats were divided into 5 groups, depending on time from AMF application until they were sacrificed (1 h, 1 day, 3 days, 7 days and 1 month after application). Two rats not exposed to AMF were used as controls. Livers were removed and evaluated; the cross-sectional area and width of the ablated region were measured. Results: During AMF exposure, the implant temperature rose to 127.8¡39.3 u C (mean ¡ standard deviation). The cross-sectional area of the ablated region was largest after 1 day and tended to decrease with time. The widths of the ablated region were 4.87¡0.22 mm, 4.15¡0.36 mm, 3.67¡0.58 mm and 3.24¡0.16 mm in the 1 day, 3 day, 7 day and 1 month groups, respectively. No significant differences (p,0.05) were seen in either cross-sectional area or width of the ablated region. Conclusion: Sufficient heat for ablation was obtained in vivo using a newly developed implanted thermal ablation device. This device may be a new option for thermal ablation therapy.

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Section: Discussionmentioning

confidence: 99%

Development of a highly efficient implanted thermal ablation device:in vivoexperiment in rat liver

Matsui

Hamuro²,

Nakamura³

et al. 2012

BJR

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“…The dimensions and schematic details of the shielding plate for analyzing the magnetic field intensity of various materials are shown in Figure 2. Figure 2 represents the model of rectangular shield plate and distance to measure the intensity of the magnetic field [31,33]. After that, we analyzed the effectiveness of magnetic field shielding (SE) of various materials in the following equation [34].…”

Section: Concept and Construction Of Shielding Systemmentioning

confidence: 99%

“…From Table 2, we found that the aperture size of 8 centimeters can perform the best results because the electric loss density is high. Furthermore, it can control the leakage of the magnetic field or the effectiveness of magnetic field shielding (SE) more effectively [33]. Considering the results of Table 2 shows that the aperture sizes of 9 and 10 centimeters the electric loss density are having highly values.…”

Section: Evaluating Electric Loss Densitymentioning

confidence: 99%

Analysis and Design of Magnetic Shielding System for Breast Cancer Treatment with Hyperthermia Inductive Heating

Thongsopa

Thosdeekoraphat

2013

International Journal of Antennas and Propagation

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An analysis and design of magnetic shielding system are presented for breast cancer treatment with hyperthermia inductive heating. It is a technique to control magnetic field intensity and relocate the heating area by using a rectangular shielding with aperture. The distribution of the lossy medium was analyzed using the finite difference time domain method. Theoretical analyses investigate whether a novel shielded system is effective for controlling the magnetic field distribution or heating position. Theoretical and experimental investigations were carried out using a lossy medium. The inductive applicator is a ferrite core with diameter of 7 cm, excited by 4 MHz signal and a maximum output power of 750 W. The results show that size of heating region can be controlled by varying the aperture size. Moreover, the investigation result revealed that the position of heating region can be relocated by changing the orientation of the ferrite core with shielded system in -axis direction. The advantage of the magnetic shielding system is that it can be applied to prevent the side effects of hyperthermia cancer treatment by inductive heating.

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“…Typically, the local temperature surrounding the treated region is maintained under 44 • C to avoid collateral damages, and the body temperature is maintained below 42 • C to make the patient feel comfortable. Different types of HT techniques have been proposed, including capacitive [3], inductive [4], phased array [5], ultrasound [6] and interstitial [7]. Typical operating frequencies include 1-300 MHz in the RF band and 300 MHz-300 GHz in the microwave band [8]; 5 kHz-1 MHz for inductive HT [8], 5-430 MHz for capacitive HT [9], and 70-2,450 MHz for phased-array HT [10].…”

Section: Introductionmentioning

confidence: 99%

Electroquasistatic Model of Capacitive Hyperthermia Affected by Heat Convection

Chen¹,

Kiang²

2019

PIER C

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An electroquasistatic (EQS) model of capacitive hyperthermia for treating lung tumors is proposed, based on which the finite element method is applied to compute the electrical potential in a human thorax model. The temperature distribution in the thorax model, which is surrounded by a bolus maintained at a constant temperature, is computed by numerically solving a bio-heat equation, which includes metabolic heat generated in the tissues, heat convection mechanism in tissues and bolus, as well as the heat delivered by the microwave field computed with the EQS model and finite element method. Temperature-dependent blood perfusion rates of blood and muscle, respectively, are adopted to account for the physiological reaction of tissues to temperature variation. By simulations, it is observed that adjusting the dielectric properties of adipose tissue via injection, the time evolution of temperature distribution can be controlled to some extent, providing more flexibility to customize a hyperthermia treatment plan for specific patient.

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Local Inductive Heating Method Using Novel High-Temperature Implant for Thermal Treatment of Luminal Organs

Cited by 10 publications

References 16 publications

Development of a highly efficient implanted thermal ablation device:in vivoexperiment in rat liver

Development of a highly efficient implanted thermal ablation device:in vivoexperiment in rat liver

Analysis and Design of Magnetic Shielding System for Breast Cancer Treatment with Hyperthermia Inductive Heating

Electroquasistatic Model of Capacitive Hyperthermia Affected by Heat Convection

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