Local immune system in oviduct physiology and pathophysiology: attack or tolerance?

Marey, Mohamed Ali; Yousef, Mohamed Samy; Kowsar, Rasoul; Hambruch, Nina; Shimizu, Takashi; Pfarrer, Christiane; Miyamoto, Akio

doi:10.1016/j.domaniend.2016.02.005

Cited by 46 publications

(34 citation statements)

References 66 publications

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“…1,37 In contrast, the oviduct activates its innate immunity under pathological conditions such as infection by a pathogen. 1,37 In contrast, the oviduct activates its innate immunity under pathological conditions such as infection by a pathogen.…”

Section: Discussionmentioning

confidence: 99%

“…1,37 In contrast, the oviduct activates its innate immunity under pathological conditions such as infection by a pathogen. 37 It has been suggested that neutrophils within the oviduct play a role in phagocytizing sperm by cell-cell attachment or by entrapping them with neutrophil extracellular traps, as well as in protecting them from potentially pathogenic microorganisms. 38 In bovine oviductal tissues, neutrophils exist constantly in stable numbers throughout the estrous cycle.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophils are the most important immune cells, being the first line of cellular defense against an acute inflammatory reaction. 37 It is well recognized that IL-8 is one of the major chemo-attractants for neutrophils. 37 It has been suggested that neutrophils within the oviduct play a role in phagocytizing sperm by cell-cell attachment or by entrapping them with neutrophil extracellular traps, as well as in protecting them from potentially pathogenic microorganisms.…”

Section: Discussionmentioning

confidence: 99%

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Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

Ohtsu

Tanaka

Seno

et al. 2017

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

Ohtsu

Tanaka

Seno

et al. 2017

American J Rep Immunol

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“…In addition, extension of infection or inflammation to the oviduct likely disrupts the delicate balance of the immune systems that are required for fertilization (Marey et al, 2016). However, an important observation for mechanisms that perturb fertility, is that postpartum uterine infection also impacts fertility after resolution of the clinical disease (Borsberry and Dobson, 1989).…”

Section: Impact Of Uterine Disease On Animal Health and Fertilitymentioning

confidence: 99%

Postpartum uterine infection and endometritis in dairy cattle

Sheldon¹,

Owens²

2017

Anim Reprod

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After parturition, uterine involution, regeneration of the endometrium, return of ovarian cyclic activity, and the control of pathogenic bacteria in the uterus is required before cows are likely to conceive again. However, pathogenic bacteria often cause uterine disease in modern dairy cattle, leading to decreased productivity and reduced fertility. This review aims to provide an overview of postpartum uterine infection and disease in dairy cattle. Metritis and endometritis are the main postpartum clinical conditions; although, subclinical endometritis is an emerging issue. Postpartum uterine disease is associated with the isolation of Escherichia coli, Trueperella pyogenes, and anaerobic pathogenic bacteria. Sensing of bacteria or their pathogen-associated molecules, such as lipopolysaccharide, by the innate immune system generates inflammatory responses. Endometrial inflammation includes increased expression of complement, calgranulins, interleukins and acute phase proteins, as well as the chemotaxis of neutrophils and macrophages to the site of infection. Uterine disease is also characterised by tissue damage, including endometrial cytolysis caused by the cholesteroldependent cytolysin, pyolysin. The responses to pathogens are energetically expensive, and depletion of the key cellular nutrients, glucose or glutamine, impairs inflammatory responses by endometrial tissues. For sustainable intensification of the dairy industry over the next 50 years, it is vital to understand why high-milkyield cows are so susceptible to uterine pathology and develop new ways to prevent uterine disease.

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“…Besides parameters used in general toxicity studies, assessment of tissue toxicity may be an assumable minimum consensus, and other Special toxicity studies and cell-based medicinal products: Special toxicity studies required for low-molecular weight compounds include carcinogenicity studies; antigenicity studies; genotoxicity studies; reproductive and developmental toxicity studies; and, if appropriate, local tolerance studies, dependence studies, and photo toxicity studies [10][11][12]. Carcinogenicity studies of chemical compounds are to be conducted if (1) the results of genotoxicity studies suggest a concern about carcinogenic potential, (2) a possible risk of cancer in humans has previously been indicated, (3) the structure-activity relationship suggests genotoxic and/or carcinogenic potential, (4) repeated-dose toxicity studies provide evidence of paraneoplastic changes, and/or (5) the parent compound or its metabolite(s) remain in the tissue for a long time, possibly resulting in local histological or pathological changes.…”

Section: Translational Medicinementioning

confidence: 99%

Regulatory Aspect of Pre-clinical Studies for Regenerative Medicine

Okura¹,

Matsuyama²

2016

Transl Med (sunnyvale)

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Regenerative cell therapy is a discipline in youth, with only limited experience in clinical practice. Once manufacturing protocols of cells have been established in vitro studies, the manufactured cells were assigned as candidates for cell-based medicinal products. To judge whether the cell-based medicinal products manufactured according to the established protocols should be valuable for further development for clinical practice, pre-clinical studies shall be conducted. In construction of a pre-clinical study package for cell-based medicinal products, the preclinical study package used for chemical compounds will help a lot. The requirements and contents of the pre-clinical studies are classified into toxicity studies (general toxicity studies and special toxicity studies), pharmacological studies (primary pharmacodynamics studies and safety pharmacological studies), pharmacokinetic studies, formulation studies, and others. The pre-clinical studies for the cell-based medicinal products are conducted to evaluate and qualify the efficacy and safety of the candidates. No wonder there is an argument about the selection of assessment parameters in toxicity, pharmacological and pharmacokinetics studies for cell-based medicinal product, because it is well-known that the cell-based medicinal products are different in properties from chemical compounds. Besides parameters used in these studies, the assessment issues may be an assumable minimum consensus, and others should be added on a case-by-case basis, depending on the cell manufacturing processes. In anticipation of the approval as the cell-based medicinal products, the possible requirements should be discussed here in the development process of such products from the standpoint of regulatory science, especially focusing on those in pre-clinical studies.

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Local immune system in oviduct physiology and pathophysiology: attack or tolerance?

Cited by 46 publications

References 66 publications

Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

Palmitic acid stimulates interleukin‐8 via the TLR4/NF‐κB/ROS pathway and induces mitochondrial dysfunction in bovine oviduct epithelial cells

Postpartum uterine infection and endometritis in dairy cattle

Regulatory Aspect of Pre-clinical Studies for Regenerative Medicine

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