Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis

Rondón, Carmen; Romero, J. J.; Lopez, Soledad; Antúnez, C.; Martín-Casañez, Enrique; Torres, Marı́a José; Mayorga, Cristobalina; R-Pena, R.; Blanca, Miguel

doi:10.1016/j.jaci.2007.01.006

Cited by 276 publications

(443 citation statements)

References 27 publications

(40 reference statements)

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“…Previous studies have shown that IgE is frequently present in the mucosal secretions of airway tract, and its level can be enhanced in human patients with asthma (8,11). Transferring of the intact allergen molecule across the airway epithelial barrier may be an important event in priming a host for an allergen, and subsequent exposure of same allergen leads to the development of allergic inflammation.…”

Section: Cd23 Transcytoses Ige-derived Ic Across Polarized Calu-3 Cellsmentioning

confidence: 99%

“…IgE is considered a major player in airway allergic inflammation. Clinical studies have found a close association between asthma and serum IgE levels, and the amount of allergen-specific IgE can be dramatically increased in sensitized or atopy patients (7,8). Allergen-specific IgE is located in the human airway, such as in nasal mucosa from allergic patients who suffer allergic rhinitis in sinonasal tissue, nasal polyposis, and allergic fungal rhinosinusitis (9)(10)(11)(12).…”

mentioning

confidence: 99%

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CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

Palaniyandi

Tomei

et al. 2011

The Journal of Immunology

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IgE-mediated allergic inflammation occurs when allergens cross-link IgE on the surface of immune cells, thereby triggering the release of inflammatory mediators as well as enhancing Ag presentations. IgE is frequently present in airway secretions, and its level can be enhanced in human patients with allergic rhinitis and bronchial asthma. However, it remains completely unknown how IgE appears in the airway secretions. In this study, we show that CD23 (FcεRII) is constitutively expressed in established or primary human airway epithelial cells, and its expression is significantly upregulated when airway epithelial cells were subjected to IL-4 stimulation. In a transcytosis assay, human IgE or IgE-derived immune complex (IC) was transported across a polarized Calu-3 monolayer. Exposure of the Calu-3 monolayer to IL-4 stimulation also enhanced the transcytosis of either human IgE or the IC. A CD23-specific Ab or soluble CD23 significantly reduced the efficiency of IgE or IC transcytosis, suggesting a specific receptor-mediated transport by CD23. Transcytosis of both IgE and the IC was further verified in primary human airway epithelial cell monolayers. Furthermore, the transcytosed Ag–IgE complexes were competent in inducing degranulation of the cultured human mast cells. Because airway epithelial cells are the first cell layer to come into contact with inhaled allergens, our study implies CD23-mediated IgE transcytosis in human airway epithelial cells may play a critical role in initiating and contributing to the perpetuation of airway allergic inflammation.

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Section: Cd23 Transcytoses Ige-derived Ic Across Polarized Calu-3 Cellsmentioning

confidence: 99%

mentioning

confidence: 99%

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

Palaniyandi

Tomei

et al. 2011

The Journal of Immunology

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“…However, local IgE production and positive nasal provocation tests can be observed in some of these patients (10)(11)(12)(13). The role of local IgE production in the inflammatory mechanisms of NAR is however unknown.…”

Section: Magnitude Of the Problemmentioning

confidence: 99%

“…Local IgE response should be studied by nasal challenge with allergens (12). Local IgE production should be tested and compared in allergic and NAR (70)(71)(72).…”

Section: Phenotype Of Narmentioning

confidence: 99%

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Bousquet

Fokkens

Burney

et al. 2008

Allergy

169

148

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA 2 LEN paper Nonallergic rhinitis (NAR) can be defined as a chronic nasal inflammation which is not caused by systemic IgE-dependent mechanisms. It is common and probably affects far more than 200 million people worldwide. Both children and adults are affected. However, its exact prevalence is unknown and its phenotypes need to be evaluated using appropriate methods to better understand its pathophysiology, diagnosis and management. It is important to differentiate between infectious rhinitis, allergic/NAR and chronic rhinosinusitis, as management differs for each of these cases. Characterization of the phenotype, mechanisms and management of NAR represents one of the major unmet needs in allergic and nonallergic diseases. Studies on children and adults are required in order to appreciate the prevalence, phenotype, severity and co-morbidities of NAR. These studies should compare allergic and NAR and consider different age group populations including elderly subjects. Mechanistic studies should be carried out to better understand the disease(s) and risk factors and to guide towards an improved diagnosis and therapy. These studies need to take the heterogeneity of NAR into account. It is likely that neuronal mechanisms, T cells, innate immunity and possibly auto-immune responses all play a role in NAR and may also contribute to the symptoms of allergic rhinitis.

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“…Althougt indication of Omalizumab restricted with moderate to severe persistent asthma who have a positive skin test or in vitro reactivity to a perennial aeroallergens, some case reports shows that omalizumab can be effective in patients with high or even low IgE level non atopic severe asthma [3]. In recent years, evidence has emerged showing that increasing number of patients previously diagnosed with nonallergic or idiopathic rhinitis developed a local allergic response with nasal-specific IgE (sIgE) production and positive nasal allergen provocation test [4]. These findings suggest the presence of local allergic rhinitis (entopy) which could not be revealed by the classic skin tests.…”

Section: To the Editormentioning

confidence: 99%

Does Local Allergy (Entopy) Exists in Asthyma?

Kılıç¹,

Kutlu²

2016

Ann Clin Anal Med

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Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis

Cited by 276 publications

References 27 publications

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper

Does Local Allergy (Entopy) Exists in Asthyma?

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Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis

Cited by 276 publications

References 27 publications

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

CD23-Dependent Transcytosis of IgE and Immune Complex across the Polarized Human Respiratory Epithelial Cells

Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper

Does Local Allergy (Entopy) Exists in Asthyma?

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Product

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Important research questions in allergy and related diseases: nonallergic rhinitis: a GA²LEN paper