Abstract:Previously, it was believed that immunoglobulin E (IgE) class switching, in response to exposure to airborne and food allergens, took place only in the spleen and large lymphoid structures of the body, before being transported to various mucosal and epithelial surfaces. However, recent studies have demonstrated that this process can take place directly in locally symptomatic regions of both the upper and lower aerodigestive tracts, without evidence of sensitization in the serum. This raises questions concernin… Show more
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