Local Hyperthermia in Oncology – To Choose or not to Choose?

Szász, András; Iluri, Nora; Szász, Olivér

doi:10.5772/52208

Cited by 27 publications

(33 citation statements)

References 239 publications

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“…It affects microvasculature nearby by elevated temperature, but only in the mild (fever) range [13]. The method has a strong synergy of the electric field and temperature [14], and shows clinical advantages [15]. These results are based on some theoretical considerations, which are presented in this article together with other supportive clinical trials with mEHT.…”

Section: Methodsmentioning

confidence: 95%

Electrokinetics of Temperature for Development and Treatment of Effusions

Szász¹,

Szigeti²,

Szász³

2017

ABB

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Introduction: Hyperthermia is a complementary therapy in oncology having various pros and contras for its application. Ascites, pleural effusion, edema and other electrolyte accumulations are frequently excluded from the treatability of the patients with heating locally or systemically. The special gathering of electrolytes is sometimes contraindicated, at times not mentioned in the clinical protocols. However, it is certainly challenging in the oncology where micro and macro edemas, as well as larger electrolyte accumulations (e.g. ascites, pleural effusion), are very frequent. Methods: Excluding patients with accumulation of free electrolytes limits the applications of hyperthermia. To find a solution we are studying the microvasculature and fluid dynamism together with the electric field effects, including the injury currents. The hyperthermia method which we investigate is the modulated electro-hyperthermia (mEHT). We use the Starling's equation and the injury current in the frame of non-equilibrium thermodynamics and in connection with the biologically closed electric circuits. Results: It is shown that mEHT, unlike the conventional hyperthermia, is applicable for patients who have edema and other free-electrolytes in the volume which is targeted. The heterogeneous heating (unlike the homogeneous, isothermal conventional hyperthermia) promotes the development of tumor-specific immune actions, and so has less adverse-effects, and longer survival time for patients in advanced, metastatic cancers too. Conclusion: mEHT is well applicable in cases of ascites, pleural effusion, edema and other electrolyte accumulations when a patient is treated in complex (complementary) oncological therapy.

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Section: Methodsmentioning

confidence: 95%

Electrokinetics of Temperature for Development and Treatment of Effusions

Szász¹,

Szigeti²,

Szász³

2017

ABB

Self Cite

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“…However, some patients developed serious complications [5]. Moreover, the published studies [4,6,7] provide no evaluation of immediate and long-term results of adjuvant chemoradiotherapy with temozolomide/lomustine (CCNU) combined with LHT in the patients with newly diagnosed MG. The purpose of our research was to assess treatment rates and acceptability of MG treatment in the course of radiosensibility enhanced by LHT.…”

Section: Introductionmentioning

confidence: 99%

“…The temperature increasing, the tumor tissue keeps on heating due to impaired blood supply, while healthy tissue is effectively cooled by the blood flow. As a result, the temperature difference is formed on both sides of the cell membrane, eventually damaging the membrane and leading to death of the tumor cells [6].…”

Section: Introductionmentioning

confidence: 99%

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Concurrent thermochemoradiotherapy for brain high-grade glioma

Ryabova¹,

Novikov²,

Чойнзонов³

et al. 2016

AIP Conference Proceedings

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Abstract. Despite the achievements in the current strategies for treatment, the prognosis in malignant glioma patients remains unsatisfactory. Hyperthermia is currently considered to be the most effective and universal modifier of radiotherapy and chemotherapy. Preliminary treatment outcomes for 28 patients with newly diagnosed (23) and recurrent (5) high-grade gliomas were presented. All the patients received multimodality treatment including surgery, thermochemoradiotherapy followed by 4 cycles of adjuvant chemotherapy. All the patients endured thermochemoradiotherapy well.

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“…The membrane structure of malignant cells absorbs the provided electromagnetic energy, and controlled signal pathways are excited. This kind of nano-targeting approach establishes a new paradigm, [3]; which was successfully applied for various malignancies [4], which could be applied not only in case of malignancies but other diseases too. When the tissue is not malignant, but partly could be selected by the radiofrequency (RF) current OTM does effect to repair the irregularities as proliferation of non-malignant tissues.…”

Section: Introductionmentioning

confidence: 99%

Newer application of Oncothermia to non-malignant diseases such as Dupuytren's contracture of the hand and chronic lower back pain lasting more than 4 weeks

Máté¹,

Molnár²,

Szőke³

et al. 2017

acupunct electrother res

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ABSTRACT:Oncothermia (OTM) is based on electromagnetic interactions with the living matter. Its nano-targeting approach establishes a new paradigm. OTM could be applied not only to treat malignancies but it is feasible to apply for other diseases too. OTH is well proven method from the laboratory level to the clinical applications, promoting the natural processes, re-establishing of the synchronization between the cells. This approach allows therapy of some nonmalignant diseases too. Our objective is to use OTM for the irregularities of tissue-growth and for pain syndromes as well. OTM uses precisely tuned radiofrequency (RF) current flowing through the treated part of the body. We made extensive study, proving in details the applicability of the OTM for Dupuytren's contracture and chronic low back pain, in conjunction with permanent acupuncture method, a modified process of traditional Chinese Medicine (TCM). The synergy of the ancient and the state-of-art medical knowledges is the basic method of the present research. Our results with application of OTM for chronic low back pain and Dupuytren's contracture shows definite improvements of the patients involved in the study. We measured the success with the Visual Analog Scale (VAS), with anecdotic quality of life (QoL), and the shortening of the of-work period due to the disease. We measured that VAS decreased significantly, the hand contracture became less rigid and less contracted. The QoL of patients improved and their complaints which blocked their regular activity has significantly reduced. OTM method was safe & no adverse effects were observed. Recognition of the distortions in the healthy tissue have some common principles and possibilities in TCM and OTM: both the methods recognize the loss of complexity of the living organization. Data of our 122 HEgYI, g., MATE, A., MOLNAR, I., SzOkE, H.` 2 recent study verified the relevant end-points of our present study: the safety, the quality of life (QoL), the prolonged painless status of the patient.

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Local Hyperthermia in Oncology – To Choose or not to Choose?

Cited by 27 publications

References 239 publications

Electrokinetics of Temperature for Development and Treatment of Effusions

Electrokinetics of Temperature for Development and Treatment of Effusions

Concurrent thermochemoradiotherapy for brain high-grade glioma

Newer application of Oncothermia to non-malignant diseases such as Dupuytren's contracture of the hand and chronic lower back pain lasting more than 4 weeks

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