Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice
Verena M. Merk,
Truong San Phan,
Alice Wiedmann
et al.
Abstract:BackgroundExtra-adrenal glucocorticoid (GC) synthesis at epithelial barriers, such as skin and intestine, has been shown to be important in the local regulation of inflammation. However, the role of local GC synthesis in the lung is less well studied. Based on previous studies and the uncontentious efficacy of corticosteroid therapy in asthma patients, we here investigated the role of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1/Hsd11b1)-dependent local GC reactivation in the regulation of allergic airway infl… Show more
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