Local GABA concentration is related to network-level resting functional connectivity

Stagg, Charlotte J.; Bachtiar, Velicia; Amadi, Ugwechi; Gudberg, Christel; Ilie, Andrei; Sampaio‐Baptista, Cassandra; O’Shea, Jacinta; Woolrich, Mark W.; Smith, Stephen M.; Filippini, Nicola; Near, Jamie; Johansen‐Berg, Heidi

doi:10.7554/elife.01465

Cited by 166 publications

(183 citation statements)

References 26 publications

(43 reference statements)

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“…Moreover, previous work using MD has shown that interhemispheric inhibition through callosal inputs weakens deprived eye-evoked responses (60). It has been hypothesized that interhemispheric inhibition (IHI) is an essential component of cortical brain development (61), and increased interhemispheric inhibition is thought to limit spontaneous correlation between homotopic brain regions (46,62,63). Indeed, increased IHI after MD is consistent with the decreased spontaneous ISA correlation resulting from MD in our data.…”

Section: Monocular Visual Deprivation Induces Intranetwork Change In supporting

confidence: 78%

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Kraft

Mitra

Bauer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Decades of work in experimental animals has established the importance of visual experience during critical periods for the development of normal sensory-evoked responses in the visual cortex. However, much less is known concerning the impact of early visual experience on the systems-level organization of spontaneous activity. Human resting-state fMRI has revealed that infraslow fluctuations in spontaneous activity are organized into stereotyped spatiotemporal patterns across the entire brain. Furthermore, the organization of spontaneous infraslow activity (ISA) is plastic in that it can be modulated by learning and experience, suggesting heightened sensitivity to change during critical periods. Here we used wide-field optical intrinsic signal imaging in mice to examine whole-cortex spontaneous ISA patterns. Using monocular or binocular visual deprivation, we examined the effects of critical period visual experience on the development of ISA correlation and latency patterns within and across cortical resting-state networks. Visual modification with monocular lid suturing reduced correlation between left and right cortices (homotopic correlation) within the visual network, but had little effect on internetwork correlation. In contrast, visual deprivation with binocular lid suturing resulted in increased visual homotopic correlation and increased anti-correlation between the visual network and several extravisual networks, suggesting cross-modal plasticity. These network-level changes were markedly attenuated in mice with genetic deletion of Arc, a gene known to be critical for activity-dependent synaptic plasticity. Taken together, our results suggest that critical period visual experience induces global changes in spontaneous ISA relationships, both within the visual network and across networks, through an Arc-dependent mechanism.infraslow activity | functional connectivity | visual critical period | activity-regulated cytoskeleton-associated protein

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Section: Monocular Visual Deprivation Induces Intranetwork Change In supporting

confidence: 78%

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Kraft

Mitra

Bauer

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Increased functional connectivity (FC) was found both in regions proximal to the electrode [30, 34, 38] and in distal regions belonging to the sensorimotor network [31, 36, 39]. Similarly, studies using graph theory, an approach taking into account network topology and synchronization between brain hubs [64], suggested a network-specific enhancement of connectivity following atDCS [32, 33, 35, 37].…”

Section: Local and Distal Connectivity Effects Of Nibsmentioning

confidence: 99%

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

et al. 2018

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Non-invasive brain stimulation (NIBS) is emerging as a promising rehabilitation tool for a number of neurodegenerative diseases. However, the therapeutic mechanisms of NIBS are not completely understood. In this review, we will summarize NIBS results in the context of brain imaging studies of functional connectivity and metabolites to gain insight into the possible mechanisms underlying recovery. We will briefly discuss how the clinical manifestations of common neurodegenerative disorders may be related with aberrant connectivity within large-scale neural networks. We will then focus on recent studies combining resting-state functional magnetic resonance imaging with NIBS to delineate how stimulation of different brain regions induce complex network modifications, both at the local and distal level. Moreover, we will review studies combining magnetic resonance spectroscopy and NIBS to investigate how microscale changes are related to modifications of large-scale networks. Finally, we will re-examine previous NIBS studies in dementia in light of this network perspective. A better understanding of NIBS impact on the functionality of large-scale brain networks may be useful to design beneficial treatments for neurodegenerative disorders.

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“…Furthermore, it appears that resting-state networks can be selectively modulated by local tDCS, with excitatory (anodal) stimulation of primary motor cortex increasing functional connectivity within the motor network (Stagg et al, 2014).…”

Section: Transcranial Electrical Stimulationmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

121

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Local GABA concentration is related to network-level resting functional connectivity

Cited by 166 publications

References 26 publications

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Visual experience sculpts whole-cortex spontaneous infraslow activity patterns through an Arc-dependent mechanism

Non-Invasive Brain Stimulation in Dementia: A Complex Network Story

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

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