Local G-quadruplexes are not a major determinant of altered gene expression in BLM-deficient cells
Thamar Jessurun Lobo,
Peter M Lansdorp,
Victor Guryev
Abstract:Mutations in theBlmgene can cause Bloom Syndrome, a genetic disorder characterized by genome instability and cancer predisposition.Blmencodes a helicase which was reported to resolve G-quadruplex DNA structuresin vitro. The G-quadruplex resolving activity of the BLM helicase has been previously implicated in altering gene expression. However, the exact mechanisms of how G-quadruplex structures may affect gene expression remain to be elucidated. We employed experimentally defined G-quadruplex forming DNA sequen… Show more
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