Local functionalization of CMOS-compatible Si3N4 Mach-Zehnder interferometers with printable functional polymers

Melnik, Eva; Müellner, Paul; Mutinati, Giorgio C.; Koppitsch, Guenther; Schrank, Franz; Hainberger, Rainer; Lämmerhofer, Michael

doi:10.1016/j.snb.2016.05.121

Cited by 16 publications

(7 citation statements)

References 36 publications

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“…Compared to conventional “asymmetric” MZI‐based biosensors with the reference arm under solid cladding, the emerging “symmetric” ones have both arms under liquid environment. [ 117 ] In 2016, the symmetric MZI‐based biosensors were reported using inkjet technique‐enabled localized functionalization of the sensing arm. [ 117 ] The experimental results indicate a nice self‐referencing property of the symmetric MZI design to environmental noises such as the liquid refractive index change.…”

Section: Silicon‐based Label‐free Optical Biosensorsmentioning

confidence: 99%

“…[ 131 ] Furthermore, site‐selective surface functionalization of multiple microrings by a non‐contact “inkjet” method has been developed for multiplexed detection since 2011. [ 117,132 ]…”

Section: Silicon‐based Label‐free Optical Biosensorsmentioning

confidence: 99%

“…[117] In 2016, the symmetric MZI-based biosensors were reported using inkjet technique-enabled localized functionalization of the sensing arm. [117] The experimental results indicate a nice self-referencing property of the symmetric MZI design to environmental noises such as the liquid refractive index change.…”

Section: On-chip Interferometer-based Optical Biosensorsmentioning

confidence: 99%

“…[131] Furthermore, site-selective surface functionalization of multiple microrings by a non-contact "inkjet" method has been developed for multiplexed detection since 2011. [117,132] In addition to silicon on-chip microring-based biosensors, significant achievements have also been accomplished on SiNon-silica platform. Ghasemi [104] Copyright 2015, Elsevier.…”

Section: Microring Resonator-based Optical Biosensorsmentioning

confidence: 99%

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Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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Section: Silicon‐based Label‐free Optical Biosensorsmentioning

confidence: 99%

Section: Silicon‐based Label‐free Optical Biosensorsmentioning

confidence: 99%

Section: On-chip Interferometer-based Optical Biosensorsmentioning

confidence: 99%

Section: Microring Resonator-based Optical Biosensorsmentioning

confidence: 99%

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Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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“…The oscillator signals are mixed and low pass filtered where the difference frequency will be proportional to the amount of target molecules. The sensing layer is inject printed onto the gold surface of the SRR and allows therefore a costless and easy adaptable sensor design [3].…”

Section: Biosensor Based On High Q Microwave Srrsmentioning

confidence: 99%

Microwave Oscillator Design for a SRR Based Biosensor Platform

Brandl¹,

Wagner²

2018

Eurosensors 2018

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A sensor for biomedical markers based on a split ring microwave resonator (SRR) was developed. The surface of the microwave resonator is covered with receptors that specifically bind to the target proteins where the local permittivity is changed. The resonator is part of a microwave oscillator circuit. Changes in the local permittivity caused by coupling of the target proteins result in a change of oscillator frequency which can be easily and accurate measured with high sensitivity.

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Recent Updates on Inkjet‐Printed Sensors

Mani

Prabhu

2019

Bioelectrochemical Interface Engineering

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Local functionalization of CMOS-compatible Si3N4 Mach-Zehnder interferometers with printable functional polymers

Cited by 16 publications

References 36 publications

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Microwave Oscillator Design for a SRR Based Biosensor Platform

Recent Updates on Inkjet‐Printed Sensors

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