Local extraction and detection of early stage breast cancers through a microneedle and nano-Ag/MBL film based painless and blood-free strategy

Chen, Liming; Zhang, Cuicui; Xiao, Jiani; You, Jie; Zhang, Wei; Liu, Yu; Xu, Liang; Liu, Anwen; Xin, Hong‐Bo; Wang, Xiaolei

doi:10.1016/j.msec.2019.110402

Cited by 38 publications

(26 citation statements)

References 43 publications

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“…Wang and co‐workers combined MNs, silver (Ag) nanomaterials, and thin films for semi‐quantitative detection of breast cancer at its early stage. [ 92 ] MNs were first used to pierce the epidermis of the mammary gland skin, and the synthesized MBL membrane (a modified pectin film) was then covered on the surface to extract and collect the extrudated tissue fluid. After being labeled by Ag 3 PO 4 /Ag nanocomposite, the carcino‐embryonic antigen (CEA), a typical tumor marker, on the membrane could be detected via a nano‐Ag‐based magnetic colorimetric sensing platform.…”

Section: Diagnostic Applications Of Mns Integrated With Npsmentioning

confidence: 99%

Microneedle Array Patches Integrated with Nanoparticles for Therapy and Diagnosis

Zhang

Wang

et al. 2021

Small Structures

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Microneedle (MN)‐based techniques are widely explored these years for biomedical applications due to their convenience, high efficiency, and excellent patient compliance. The combination of MN array patches with nanoparticles (NPs) expands the applications of MNs with dynamic characteristics and facilitates on‐demand drug release while reducing systemic toxicity and enhancing therapeutic efficacy. This review summarizes the recent advances of MNs integrated with NPs as a transdermal approach for various applications. Representative therapeutic or diagnostic studies associated with diabetes, cancer, vaccine, obesity, hair growth, and acne vulgaris are highlighted in detail. Future perspectives for such theranostic devices in biomedical fields are also discussed.

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Section: Diagnostic Applications Of Mns Integrated With Npsmentioning

confidence: 99%

Microneedle Array Patches Integrated with Nanoparticles for Therapy and Diagnosis

Zhang

Wang

et al. 2021

Small Structures

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“…The intensity of the blue color is related to the target concentration. Chen et al developed a colorimetric method for early breast cancer detection [120]. Solid MN was adopted to insert into tumor tissue, while ISF was collected through a synthetic breathable thin membrane by siphon effect.…”

Section: Colorimetric Determinationmentioning

confidence: 99%

Engineering Microneedles for Therapy and Diagnosis: A Survey

et al. 2020

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Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs’ micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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“…Recently, MN platforms for bio-uid extraction and biomarker detection via colorimetric reactions attracted signicant interest, especially as they bypass the need for complex in-lab apparatus, and pave the way for future use in self-diagnosis at home. [101][102][103] He et al developed a hydrogel MN patch made of polyvinyl alcohol (PVA) and chitosan (CS) for point-of-care testing. Aer the extraction process, the target biomarkers from the MN patch were rapidly recovered by gentle heating because the PVA/CS hydrogel is water-soluble at higher temperatures.…”

Section: Detection and Diagnosis Using Mnsmentioning

confidence: 99%