Local excision of duodenal gastrointestinal stromal tumor

Lanuke, Kathryn; Bathe, Oliver F.; Mack, Lloyd A.

doi:10.1002/jso.20618

Cited by 15 publications

(6 citation statements)

References 8 publications

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“…The main question here is whether limited resection is an oncologically adequate alternative to pancreaticoduodenectomy. So far, there have been few data regarding the oncological results of either procedure50–53; the only series advocating the use of Whipple's procedure did not assess the outcome of other, more limited approaches54.…”

Section: Duodenummentioning

confidence: 99%

Enantioselective Total Synthesis of Octalactin A Using Asymmetric Aldol Reactions and a Rapid Lactonization To Form a Medium‐Sized Ring

Shiina

Hashizume

Yamai

et al. 2005

Chemistry A European J

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Octalactin A, an antitumor agent containing an eight-membered lactone moiety, has been stereoselectively prepared by means of enantioselective aldol reactions of selected silyl enolates with achiral aldehydes, promoted by a chiral Sn(II) complex. The medium-sized lactone part was effectively constructed by way of a new and rapid mixed-anhydride lactonization using 2-methyl-6-nitrobenzoic anhydride (MNBA) with a catalytic amount of 4-(dimethylamino)pyridine (DMAP) or 4-(dimethylamino)pyridine 1-oxide (DMAPO). The use of only 5 mol % of DMAP or 2 mol % of DMAPO rapidly promoted formation of the medium-sized ring of the octalactin, demonstrating the remarkable efficiency of the new lactonization protocol.

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Section: Duodenummentioning

confidence: 99%

Enantioselective Total Synthesis of Octalactin A Using Asymmetric Aldol Reactions and a Rapid Lactonization To Form a Medium‐Sized Ring

Shiina

Hashizume

Yamai

et al. 2005

Chemistry A European J

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“…2,4,6,[11][12][13] Unlike carcinomas, GISTs typically do not infiltrate into adjacent structures and rarely metastasize to lymph nodes. 14 Because of their anatomic location, the optimal surgical procedure for duodenal GISTs remains poorly defined. Specifically, while local resection (LR) may be technically feasible, anatomical considerations may make LR more difficult due the proximity of other anatomical structures, including the duodenal papilla, pancreas, and the biliary and pancreatic ducts.…”

mentioning

confidence: 99%

Presentation and Management of Gastrointestinal Stromal Tumors of the Duodenum: A Multi-Institutional Analysis

et al. 2012

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“…For stromal tumors where there is more expansive growth or rare lymph node metastasis, excessive expansion excision would not prolong the survival time of the patients. In a study that advocated ensuring a negative margin necessary to perform the required surgical resection, a wide range of lymph node dissection was not advocated (20). In our study, there were two cases of non-ampullary duodenal tumors.…”

Section: Discussionmentioning

confidence: 99%

Experience in clinical diagnosis and treatment of duodenal tumors

Wang¹,

Ding

Huang

et al. 2016

Molecular and Clinical Oncology

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Small bowel tumors are rare tumors. Duodenal tumors occur more commonly compared with other small intestinal tumors. To summarize the clinicopathological features of duodenal tumors, in the present study 44 cases of duodenal tumors were collected, and the comparative clinicopathological characteristics between tumors of the ampulla and non-ampulla, the choice of treatment, and differences in the prognosis, were analyzed. The pathological type identified was predominantly adenocarcinoma; periampullary duodenal tumors were almost classifiable as adenocarcinoma in terms of their type. Non-ampulla duodenal tumors also included rare pathological types, such as stromal tumor and large B-cell lymphoma. The symptoms of duodenal tumors were non-specific, therefore rendering early diagnosis and treatment difficult. Due to jaundice, periampullary duodenal tumors were diagnosed earlier than non-ampulla duodenal tumors. Endoscopy and computed tomography (CT) examinations were valuable in terms of diagnosis, and were used as a means of screening. Carcinoembryonic antigen (CEA) and cancer antigen 199 (CA199) were revealed to be important as biomarkers. Radical surgery was the most effective treatment. Pancreaticoduodenectomy was revealed to be applicable in all cases of duodenal tumors. For non-ampulla duodenal tumors, partial duodenum resection and subtotal gastrectomy were appropriate for selection as methods of treatment. No survival benefits were identified for adjuvant chemotherapy. Duodenal tumors were shown to be a rare neoplasm with atypical symptoms; they should be diagnosed and treated as early as possible; CT and gastroscopy may be used for screening, radical surgery offers the best treatment; pancreatoduodenectomy is not the only surgery option available; and chemotherapy did not result in any survival benefits.

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Local excision of duodenal gastrointestinal stromal tumor

Cited by 15 publications

References 8 publications

Enantioselective Total Synthesis of Octalactin A Using Asymmetric Aldol Reactions and a Rapid Lactonization To Form a Medium‐Sized Ring

Enantioselective Total Synthesis of Octalactin A Using Asymmetric Aldol Reactions and a Rapid Lactonization To Form a Medium‐Sized Ring

Presentation and Management of Gastrointestinal Stromal Tumors of the Duodenum: A Multi-Institutional Analysis

Experience in clinical diagnosis and treatment of duodenal tumors

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