Local drug delivery systems in the management of periodontitis: A scientific review

Rajeshwari, H R; Dhamecha, Dinesh; Jagwani, Satveer; Rao, Meghana; Jadhav, Kiran; Shaikh, Shabana; Puzhankara, Lakshmi; Jalalpure, Sunil

doi:10.1016/j.jconrel.2019.06.038

Cited by 131 publications

(94 citation statements)

References 169 publications

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“…6 However, the destruction of normal flora and difficulty in maintaining local therapeutic concentrations have limited the use of antibiotics. 7 And overuse of antibiotics has led to the emergence of the drug-resistant bacteria, thus making antibiotic treatments ineffective. Therefore, it is vital to develop a new strategy for not only achieving the removal of residual bacteria in the early stage of treatment, but also for maintaining a low number of bacteria in the long term.…”

Section: Introductionmentioning

confidence: 99%

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

Lin¹,

He²,

Liu³

et al. 2020

IJN

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Background: Periodontal pathogenic bacteria promote the destruction of periodontal tissues and cause loosening and loss of teeth in adults. However, complete removal of periodontal pathogenic bacteria, at both the bottom of the periodontal pocket and the root bifurcation area, remains challenging. In this work, we explored a synergistic antibiotic and photothermal treatment, which is considered an alternative strategy for highly efficient periodontal antibacterial therapy. Methods: Mesoporous silica (MSNs) on the surface of Au nanobipyramids (Au NBPs) were designed to achieve the sustained release of the drug and photothermal antibacterials. The mesoporous silica-coated Au NBPs (Au NBPs@SiO 2) were mixed with gelatin methacrylate (GelMA-Au NBPs@SiO 2). Au NBPs@SiO 2 and GelMA-Au NBPs@SiO 2 hybrid hydrogels were characterized, and the drug content and photothermal properties in terms of the release profile, bacterial inhibition, and cell growth were investigated. Results: The GelMA-Au NBPs@SiO 2 hybrid hydrogels showed controllable minocycline delivery, and the drug release rates increased under 808 nm near-infrared (NIR) light irradiation. The hydrogels also exhibited excellent antibacterial properties, and the antibacterial efficacy of the antibiotic and photothermal treatment was as high as 90% and 66.7% against Porphyromonas gingivalis (P. gingivalis), respectively. Moreover, regardless of NIR irradiation, cell viability was over 80% and the concentration of Au NBPs@SiO 2 in the hybrid hydrogels was as high as 100 µg/mL. Conclusion: We designed a new near-infrared light (NIR)-activated hybrid hydrogel that offers both sustained release of antibacterial drugs and photothermal treatment. Such sustained release pattern yields the potential to rapidly eliminate periodontal pathogens in the periodontal pocket, and the photothermal treatment maintains low bacterial retention after the drug treatment.

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Section: Introductionmentioning

confidence: 99%

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

Lin¹,

He²,

Liu³

et al. 2020

IJN

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“…In particular, in supportive periodontal therapy, local antimicrobials are applied to treat residuals pockets [8]. Topical application can lead to a high concentration of the antimicrobial which is active in the diseased area and selectively targets microorganisms in the diseased area [9,10]. Systemic side effects can be reduced and application of controlled compliance by the periodontist to the patient is guaranteed [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…In order to avoid rapid depletion of the therapeutics and to keep them in place, sustained or controlled release devices are needed [9]. Desirable properties of the devices include easy application, biodegradability, and a continuous release of an antimicrobial-active substance over a defined time [9,10].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy

et al. 2020

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Periodontal therapy using antimicrobials that are topically applied requires slow or controlled release devices. The in vitro antimicrobial activity of biodegradable polymer formulations that contain a new minocycline lipid complex (P-MLC) was evaluated. The new P-MLC formulations that contained 11.5% minocycline were compared with pure minocycline or an existing commercial formulation, which included determination of minimal inhibitory concentration (MIC) values against two oral bacteria and activity on six-species periodontal biofilm. Moreover, the flow of gingival crevicular fluid (GCF) was modeled up to 42 days and the obtained eluates were tested both for MIC values and inhibiting biofilm formation. In general, MICs of the P-MLC formulations were slightly increased as compared with pure minocycline. Biofilm formation was clearly inhibited by all tested formulations containing minocycline with no clear difference between them. In 3.5 day old biofilms, all formulations with 250 µg/mL minocycline decreased bacterial counts by 3 log10 and metabolic activity with no difference to pure antimicrobials. Eluates of experimental formulations showed superiority in antimicrobial activity. Eluates of one experimental formulation (P503-MLC) still inhibited biofilm formation at 28 days, with a reduction by 1.87 log10 colony forming units (CFU) vs. the untreated control. The new experimental formulations can easily be instilled in periodontal pockets and represent alternatives in local antimicrobials, and thus warrant further testing.

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“…Periodontal disease or periodontitis, which is a common inflammatory chronic disease, causes irreversible periodontal complex destruction, disconnection of principal fibrous ligamentous tissues, and consequent loss of barrier function [19,20,21]. The invasion of oral bacteria or the formation of dental biofilm (or the maturation of dental plaque) on tooth surfaces are mainly associated with pathogenesis of periodontal disease caused by host inflammatory responses [21,22].…”

Section: Introductionmentioning

confidence: 99%

Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms

Park

2019

IJMS

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Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey’s fiber anchorages for state-of-the-art periodontal tissue engineering.

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Local drug delivery systems in the management of periodontitis: A scientific review

Cited by 131 publications

References 169 publications

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

<p>Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect</p>

In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy

Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms

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