Local drug delivery for oral mucosal diseases: challenges and opportunities

Sankar, Vidya; Hearnden, Vanessa; Hull, Katrusha; Juras, Danica Vidović; Greenberg,; Kerr, A. Ross; Lockhart, PB; Patton, Lauren L.; Porter, Stephen; Thornhill, Martin H.

doi:10.1111/j.1601-0825.2011.01793.x

Cited by 129 publications

(124 citation statements)

References 102 publications

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“…Cancers originating in the head and neck region and oral cavity are potentially more accessible to local chemotherapeutic drug delivery 17 and could ultimately utilise the transmucosal delivery capability of these polymersomes seen in vitro 18 . Here we investigate the use of polymersomes comprised of the amphiphilic block copolymer poly 2-(methacryloyloxy)ethyl phosphorylcholine (PMPC) coupled with the pH-sensitive copolymer poly 2-(diisopropylamino)ethyl methacrylate (PDPA) for anti-cancer drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation

et al. 2014

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Polymersomes have the potential to encapsulate and deliver chemotherapeutic drugs into tumour cells, reducing off-target toxicity that often compromises anti-cancer treatment. Here we assess the ability of the pH-sensitive poly 2-(methacryloyloxy)ethyl phosphorylcholine (PMPC)-poly 2-(diisopropylamino)ethyl methacrylate (PDPA) polymersomes to encapsulate chemotherapeutic agents for effective combinational anti-cancer therapy. Polymersome uptake and ability to deliver encapsulated drugs into healthy normal oral cells and oral head and neck squamous cell carcinoma (HNSCC) cells was measured in two and three-dimensional culture systems. PMPC-PDPA polymersomes were more rapidly internalised by HNSCC cells compared to normal oral cells. Polymersome cellular up-take was found to be mediated by class B scavenger receptors.We also observed that these receptors are more highly expressed by cancer cells compared to normal oral cells, enabling polymersome-mediated targeting. Doxorubicin and paclitaxel were encapsulated into pH-sensitive PMPC-PDPA polymersomes with high efficiencies either in isolation or as a dual-load for both singular and combinational delivery. In monolayer culture, only a short exposure to drug-loaded polymersomes was required to elicit a strong cytotoxic effect. When delivered to three-dimensional tumour models, PMPC-PDPA polymersomes were able to penetrate deep into the centre of the spheroid resulting in extensive cell damage when loaded with both singular and dual-loaded chemotherapeutics. PMPC-PDPA polymersomes offer a novel system for the effective delivery of chemotherapeutics for the treatment of HNSCC.Moreover, the preferential internalisation of PMPC polymersomes by exploiting elevated scavenger receptor expression on cancer cells opens up the opportunity to target polymersomes to tumours.3

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Section: Introductionmentioning

confidence: 99%

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation

et al. 2014

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“…From the above nature of the disease it is made evident that the drug used for its treatment should not only cross the permeability barrier but also be retained in the basal layer and the connective tissue. 4 This proves the fact that local drug delivery is more effective in treatment of Oral lichen planus. The drug delivered should not be lost in the systemic circulation unless the disease is of extensive nature.…”

Section: Discussionmentioning

confidence: 80%

Drug Delivery Tailored for the Need– Case Series of Oral Lichen Planus

Venugopal¹,

Maheswari²

2018

JYP

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Lichen planus is an inflammatory mucocutaneous disorder. The pathogenesis of lichen planus is predominantly T cell mediated. The condition is associated with it are hepatitis C, graft versus host disease, medications [antiarrythmic drugs, anti-hypertensive], dental materials [amalgam restoration] etc. Immune modulators have been widely used in the management of lichen planus. Corticosteroids are the most widely used among them. There is various mode of delivering corticosteroids in oral lichen planus. The systemic administration is reported to cause more adverse drug reaction when compared to local drug delivery systems. The case series describes three cases of lichen planus at different sites. It also high lights the site-specific treatment applied in them.

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“…Membrane coated granules released from suprabasal cells of epithelium, in turn, release lipophilic materials into the intercellular spaces, increasing epithelial cohesion. [9] Patient acceptability Topical drugs cause taste disturbances, may interfere in speech and eating. The drug should be easy for self-administration.…”

Section: Lipid Compositionmentioning

confidence: 99%

Topical drug delivery: An essential aid in the management of oral diseases

Shastry¹,

Sanjay²,

Kaul³

et al. 2015

JCRI

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Topical medications play an important role in the management of oral lesions. Various topical medications ranging from topical anesthetics to topical antineoplastics have been widely used in dentistry. Topical medications have been extensively used as the first line of therapy in many conditions such as vesiculobullous diseases, oral infections like candidiasis, herpes simplex, potentially malignant disorders, neuropathic pain, and oral mucositis. Topical drug therapy provides targeted and a more efficient drug delivery options for the local oral lesions as compared to systemic therapy. While accessibility, lower systemic side effects, and many other advantages are associated with the usage of topical oral medications, several challenges are also faced such as taste alterations, poor penetration, and limited surface area. The objective of this review is to provide insight into the mechanism of topical drug delivery, summary of various topical medications used in oral lesions, advantages and disadvantages, characteristic of oral mucosa and various challenges faced in delivering topical medications.

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Local drug delivery for oral mucosal diseases: challenges and opportunities

Cited by 129 publications

References 102 publications

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation

Polymersome-Mediated Delivery of Combination Anticancer Therapy to Head and Neck Cancer Cells: 2D and 3D in Vitro Evaluation

Drug Delivery Tailored for the Need– Case Series of Oral Lichen Planus

Topical drug delivery: An essential aid in the management of oral diseases

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