Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations

McKinnon, Sally; Guatelli, Susanna; Incerti, S.; Ivanchenko, V. N.; Konstantinov, Konstantin; Corde, Stéphanie; Lerch, Michael L. F; Tehei, Moeava; Rosenfeld, Anatoly B.

doi:10.1016/j.ejmp.2016.11.112

Cited by 30 publications

(23 citation statements)

References 38 publications

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“…Cerium oxide nanoparticles could sensitize pancreatic cancer cells to kV X-rays by improving ROS production, as shown by in vitro assays as well as xenografts 185 . Other groups also reported similar results when evaluating X-rays, electrons, and protons 186 - 188 . Thus, like PtNPs and Bi 2 Se 3 NPs, CeO 2 NPs have dual effects on radiotherapy.…”

Section: Metal-based Nanoenhancers For Ionizing Rasupporting

confidence: 56%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past decade, there has been growing interest in using high Z (atomic number) elements (materials) as radiosensitizers. New strategies in nanomedicine could help to improve cancer diagnosis and therapy at cellular and molecular levels. Metal-based nanoparticles usually exhibit chemical inertness in cellular and subcellular systems and may play a role in radiosensitization and synergistic cell-killing effects for radiation therapy. This review summarizes the efficacy of metal-based NanoEnhancers against cancers in both in vitro and in vivo systems for a range of ionizing radiations including gamma-rays, X-rays, and charged particles. The potential of translating preclinical studies on metal-based nanoparticles-enhanced radiation therapy into clinical practice is also discussed using examples of several metal-based NanoEnhancers (such as CYT-6091, AGuIX, and NBTXR3). Also, a few general examples of theranostic multimetallic nanocomposites are presented, and the related biological mechanisms are discussed.

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Section: Metal-based Nanoenhancers For Ionizing Rasupporting

confidence: 56%

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

et al. 2018

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“…The results of this research have significant impact on studies which intend to investigate the physics mechanism at the basis of the radiobiological effects of radiation at cellular and sub-cellular level in radiotherapeutic applications (Incerti et al 2016), such as the investigation of dose enhancement produced by high-Z nanoparticles (e.g. (Sakata et al 2016, Douglass et al 2013, Engels et al 2016, McKinnon et al 2016a, McKinnon et al 2016b), the characterisation of radio-emitters for Targeted Particle Therapy (e.g. (Huang et al 2012)), the study of the effect of radiation in cellular targets other than the nucleus (e.g.…”

Section: Discussionmentioning

confidence: 99%

Investigation of track structure and condensed history physics models for applications in radiation dosimetry on a micro and nano scale in Geant4

Lazarakis

Incerti

Ivanchenko³

et al. 2018

Biomed. Phys. Eng. Express

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“…The experimental setup of this work has been chosen primarily for the evaluation of the Geant4 models available for nanoscale simulation and therefore it has been as simple as possible. McKinnon et al (2016) implemented a more realistic geometry comprising the simulation of the full proton track structure through and outside the NP. The different geometry implemented resulted to different dose enhancement values.…”

Section: Discussionmentioning

confidence: 99%

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

Sotiropoulos

Taylor

Henthorn

et al. 2017

Biomed. Phys. Eng. Express

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Gold nanoparticles (GNPs) have shown a potential as a radiosensitizer in radiotherapy. The radiosensitization effect is thought to be linked to the increased dose deposition around the GNP. Monte Carlo simulations have been implemented for the calculation of the dose distributions around the GNPs and have been used for the calculation of the dose enhancement. They have also been imported to radiobiological models to predict biological endpoints. This work assessed the implications of different physical interaction models on the dose distribution and dose enhancement of GNPs surrounded by water under proton irradiation. The Penelope and Livermore physical interaction model implementation of the Geant4 simulation toolkit were compared considering the following parameters: i) GNP size, ii) proton energy, and iii) alternative physics model parameters in the gold or water medium. We found that neither the dose distribution nor the dose enhancement is sensitive to the model selection after the first 100 nm from the GNP surface. Within the first 100 nm the Livermore models calculated a higher dose, attributed to a higher production of low energy secondary electrons inside the GNP.

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Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations

Cited by 30 publications

References 38 publications

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Investigation of track structure and condensed history physics models for applications in radiation dosimetry on a micro and nano scale in Geant4

Geant4 interaction model comparison for dose deposition from gold nanoparticles under proton irradiation

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