Local detection of pH-induced disaggregation of biocompatible micelles by fluorescence switch ON

Abstract

Fluorogenic nanoparticles (NP) able to sense different physiological environments and respond with disaggregation and fluorescence switching OFF/ON are powerful tools in nanomedicine as they can combine diagnostic with therapeutic action....

pH Switchable Water Dispersed Photocatalytic Nanoparticles

“…Hence, ROS generation can be switched ON/OFF in time simply by controlling the irradiation intensity, and in space by focusing the excitation light on the desired target volume. In this framework, the additional possibility of triggering the response to light by an additional chemical stimulus (local pH) promises to guarantee enhanced control of the process as well as specificity [9] …”

“…In this framework, the additional possibility of triggering the response to light by an additional chemical stimulus (local pH) promises to guarantee enhanced control of the process as well as specificity. [9] Here we describe dual stimuli-responsive nanoparticles (DSR NP) that efficiently generate ROS only upon simultaneous luminous and chemical stimulation. In particular these NP are poorly efficient ROS photo-generators at neutral pH, but they produce ROS very efficiently at acidic pH.…”

Design of biomaterials through direct ring-opening metathesis polymerisation of functionalised cyclic alkenes

“…Various types of fluorescent molecules can be introduced, as long as they can coexist with the metathesis catalyst used, and their structure does not interfere with the reaction activity of the monomer. For example, coumarin, 244 DABCYL, fluorescein, 208,236,245 EDANS, anthracene, rhodamine B, 207,208,244,[246][247][248] 7-chloro-4nitrobenzo-2-oxa-1,3-diazole (NBD), 244,249 Cy5.5, 250 Oregon Green, 251 indocyanine green, 195,[252][253][254] perylene diimide, 255 9,10-diphenylanthracene, 208 pyrene, 256 fluorene, 257 and nearinfrared (NIR) fluorescent cyanine, 258 can all be used. Lienkamp et al synthesised derivatives of oxanorbornenimide and 5-norbornene-2-carboxylic acid amide, modified with nitrobenzofurazan, coumarin, and rhodamine B 244 (Fig.…”

Recent Applications of Melanin-like Nanoparticles as Antioxidant Agents

“…Some nanosized materials present unique properties [ 45 , 46 , 47 , 48 ] including preventive or radical trapping activity possess characteristics that are similar to the aforementioned enzymes and are, therefore, called nanozymes [ 49 ]. These nano-AOXs present several advantages with respect to other molecular AOXs [ 50 ].…”