Local Delivery of VEGF and SDF Enhances Endothelial Progenitor Cell Recruitment and Resultant Recovery from Ischemia

Anderson, Erin M.; Kwee, Brian J.; Lewin, Sarah A.; Raimondo, Theresa M.; Mehta, Manav; Mooney, David J.

doi:10.1089/ten.tea.2014.0508

Cited by 45 publications

(37 citation statements)

References 52 publications

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“…2 Earlier studies also showed that daily systemic administration of recombinant human VEGF 165 isoform alone over the period of a week mobilized and increased the number of circulating BM-derived EPCs in mice. 5 However, although bolus VEGF injection provided therapeutic benefit in animal studies, there was no significant improvement in clinical trials presumably due to rapid washout of the protein from bolus delivery strategies.…”

Section: Delivery Of Soluble Factors For Enhanced Recruitmentmentioning

confidence: 99%

“…For example, SDF-1, VEGF, sphingosine-1-phosphate (S1P), and other soluble prosurvival factors, are upregulated in the hypoxic tissue and have been shown to play key roles in directing EPC migration. 2,25,43,85 VEGF, a key growth factor involved in both angiogenesis and vasculogenesis, has been shown to mobilize BM-derived progenitors into circulation. 5,45 A central chemokine involved in EPC homing, SDF-1, is also produced within the hypoxic stem cell niches of the BM and mediates chemotaxis of various cell types that express the receptor CXCR4.…”

Section: Matrix Modulation In Vascular Diseasesmentioning

confidence: 99%

“…2,61 Systemic infusion by intracardiac injection of culture-expanded EPCs derived from peripheral blood has been shown to enhance blood perfusion and somewhat prevent limb loss (50% recovery) in murine models of hindlimb ischemia. 33 Here, 56% of blood vessels in the ischemic tissue contained transplanted human EPCs, demonstrating the reparative function of these cells.…”

Section: Systemic Infusion or Local Bolus Injection Of Epcsmentioning

confidence: 99%

“…62 Albeit simple delivery routes, these methods of cellular infusion often have limited efficacy due to high cell death and poor recruitment and/or retention within the ischemic target. 2,70 In particular, the majority of systemically infused cells often get trapped in the microvasculature of other off-target organs/tissues. 27,64 For example, pulmonary passage is a major obstacle due to both the size of the cells and adhesion to the vascular endothelium.…”

Section: Systemic Infusion or Local Bolus Injection Of Epcsmentioning

confidence: 99%

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The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

Williams

Silva

2015

Ann Biomed Eng

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Section: Delivery Of Soluble Factors For Enhanced Recruitmentmentioning

confidence: 99%

Section: Matrix Modulation In Vascular Diseasesmentioning

confidence: 99%

Section: Systemic Infusion or Local Bolus Injection Of Epcsmentioning

confidence: 99%

Section: Systemic Infusion or Local Bolus Injection Of Epcsmentioning

confidence: 99%

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The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

Williams

Silva

2015

Ann Biomed Eng

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“…9 days post-injection, the hydrogel treatment demonstrated 10-fold enhanced recovery of tissue perfusion and vessel network construction in a murine hindlimb ischemia model, which was also verified by CD31 + staining. One other group used alginate hydrogels to co-delivery vascular endothelial growth factor (VEGF) and stromal derived factor (SDF) to PAD injury sites [112]. Although these growth factors were not previously used in the human clinical trials, it was hypothesized that local and sustained delivery of the two growth factors would better recruit and mobilize circulating angiogenic cells to the injury site.…”

Section: Alginate and Gelatin Hydrogels Utilization For Growth Factormentioning

confidence: 99%

Engineering Integrative Stem Cell and Biomaterial Therapies for Peripheral Artery Disease

Balikov

Lee

Boire

et al. 2015

Biosystems &Amp; Biorobotics

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Because of their potential to regenerate tissues and organs, stem cells garner extensive interest worldwide for treating a wide range of degenerative diseases. In numerous efforts, a variety of stem cell formats have been considered for therapeutic purposes to combat such pathologies, one being vascular-related diseases. In particular, the prevalence of peripheral artery disease (PAD) has steadily increased with the growth of the aging population in many first-world countries. Considering this disturbing trend as well as the obesity epidemic and the ballooning population growth in third-world nations, the burden of PAD is expected to increase worldwide to alarming levels in the coming decades. The advent of stem cell treatments could stymie this burden by alleviating the complications and improving upon the less-than-satisfactory outcomes from current standard-of-care surgical/pharmacological interventions for PAD. This chapter reviews the relevant, cutting-edge clinical and animal model research efforts in the field and explores the remaining questions as they pertain to convergence technologies that may provide the potential for stem cells to reverse PAD-induced tissue damage. Harnessing and translating this potential to create more viable and efficacious PAD treatments should be of paramount global and public health concern.

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Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

Wang

Rivera‐Bolanos

Jiang

et al. 2019

Adv Funct Materials

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Stem cell-based therapies can potentially regenerate many types of tissues and organs, thereby providing solutions to a variety of diseases and injuries. However, acute cell death, uncontrolled differentiation, and low functional engraftment yields remain critical obstacles for clinical translation. Advanced functional biomaterial scaffolds that can deliver stem cells to the targeted tissues/organs and promote stem cell survival, differentiation, and integration to host tissues may potentially transform the clinical outcome of stem cellbased regenerative therapies. In this review, the authors briefly summarize sources of stem cells for transplantation, present the current state of the art in biomaterial design for stem cell delivery, and provide critical analysis for existing materials. Applications to the cardiovascular, neural, and musculoskeletal systems are highlighted with recent nonclinical studies and clinical trials. The authors also discuss how advances in biomaterials research can contribute to regenerative medicine research and stem cell therapies. application in the clinical setting. These challenges include the manipulation of stem cell fate pre-and post-transplantation and protection of the cells during and after their delivery to the target site. [3] The microenvironment, also referred to as stem cell niche, plays key roles in stem cell fate determination. [4] In vivo, the interplay among complex microenvironmental cues precisely regulate stem cell function so they may undergo self-renewal to maintain the stem cell pool or to undergo differentiation to regenerate tissue. However, the majority of current stem cell transplant strategies in clinical trials use injections with a buffer fluid, which provides insufficient protection and manipulation of cell fate. [5] As a result, the vast majority of transplanted cells die during their delivery or within a short time thereafter. Engineering approaches, especially in the biomaterials field, offer strategies to address the challenges and current limitations of stem cell therapy. Innovative design of biomaterials enables delicate control of their biophysical and biochemical properties, which provides an artificial niche to regulate stem cell functions. Delivery of cells via engineered biomaterial carriers can promote cell survival by reducing the microenvironmental shock (shear stress, inflammation, etc.), improving cell retention by preventing cell leakage and enhancing regenerative responses from delivered cells by manipulating stem cell fate. [6] In this review, we summarize and provide perspective on stem cell sources and the state of the art in the design, fabrication, and application of advanced functional biomaterials for stem cell delivery. We discuss current stem cell phenotypes and the requirements in biomaterial design and fabrication for successful stem cell transplantation. We also highlight recent nonclinical and clinical studies of stem cell therapy in the cardiovascular, neural, and musculoskeletal systems. Lastly, we conclude with an outlo...

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Local Delivery of VEGF and SDF Enhances Endothelial Progenitor Cell Recruitment and Resultant Recovery from Ischemia

Cited by 45 publications

References 52 publications

The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

The Role of Synthetic Extracellular Matrices in Endothelial Progenitor Cell Homing for Treatment of Vascular Disease

Engineering Integrative Stem Cell and Biomaterial Therapies for Peripheral Artery Disease

Advanced Functional Biomaterials for Stem Cell Delivery in Regenerative Engineering and Medicine

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