Local delivery of EGF–liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression

Alves, José Bento; Ferreira, Cynthia Lopes; Martins, Aline Stangherlin; Silva, Gerluza A.B.; Alves, Guilherme Dias; Paulino, Tony de Paiva; Ciancaglini, Pietro; Thedei, Geraldo; Napimoga, Marcelo Henrique

doi:10.1016/j.lfs.2009.09.010

Cited by 37 publications

(41 citation statements)

References 36 publications

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“…Those experiments would validate the use of these nanovesicles in promoting or delaying calcification, and such an artificial nanovesicular system could also potentially prove useful for the repair/treatment of craniofacial and other skeletal defects and to facilitate the mineralization of titanium-based tooth implants. In addition, the property of liposome to carrying in aqueous or lipid bilayers could be used as a system for delivery of drug or dyes with many applications (Santos et al 2005(Santos et al , 2007Saddi et al 2008;Alves et al 2009). …”

Section: New Perspectives For Applications Of Proteoliposomesmentioning

confidence: 99%

Proteoliposomes in nanobiotechnology

et al. 2012

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Proteoliposomes are systems that mimic lipid membranes (liposomes) to which a protein has been incorporated or inserted. During the last decade, these systems have gained prominence as tools for biophysical studies on lipid-protein interactions as well as for their biotechnological applications. Proteoliposomes have a major advantage when compared with natural membrane systems, since they can be obtained with a smaller number of lipidic (and protein) components, facilitating the design and interpretation of certain experiments. However, they have the disadvantage of requiring methodological standardization for incorporation of each specific protein, and the need to verify that the reconstitution procedure has yielded the correct orientation of the protein in the proteoliposome system with recovery of its functional activity. In this review, we chose two proteins under study in our laboratory to exemplify the steps necessary for the standardization of the reconstitution of membrane proteins in liposome systems: (1) alkaline phosphatase, a protein with a glycosylphosphatidylinositol anchor, and (2) Na,K-ATPase, an integral membrane protein. In these examples, we focus on the production of the specific proteoliposomes, as well as on their biochemical and biophysical characterization, with emphasis on studies of lipid-protein interactions. We conclude the chapter by highlighting current prospects of this technology for biotechnological applications, including the construction of nanosensors and of a multiprotein nanovesicular biomimetic to study the processes of initiation of skeletal mineralization.

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Section: New Perspectives For Applications Of Proteoliposomesmentioning

confidence: 99%

Proteoliposomes in nanobiotechnology

et al. 2012

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“…The use of endothelial growth factors [20], prostaglandins [21], RANKL [22], and leukotrienes [23] was reported with questionable efficiency and limited understanding of their mechanism of action. Recently, device-assisted orthodontic therapy has become an area of interest.…”

Section: Introductionmentioning

confidence: 99%

Velocity of orthodontic active space closure with and without photobiomodulation therapy: a single-center, cluster randomized clinical trial

Samara¹,

Nahas²,

Rastegar-Lari

2018

Laser Dent Sci

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“…The superelasticity of the coil spring ensured a constant force during the whole time of coil spring activation according to the methodology used by Alves et al . and Suzuki et al . .…”

Section: Methodsmentioning

confidence: 90%

“…It has been a consensus that OPG/RANK-L/RANK system regulates the bone turnover (3,5,30,42,43) by exerting biologic effects on osteoblasts/osteoclasts cells and that photobiomodulation may modulate this bone turnover mechanism (9,33). The major role of RANK-L/RANK is to induce osteoclast activation and stimulate bone resorption.…”

Section: Discussionmentioning

confidence: 99%

Effects of Photobiomodulation on SOFAT, A T‐cell‐derived Cytokine, May Explain Accelerated Orthodontic Tooth Movement

Jettar

Napimoga

Freitas

et al. 2018

Photochem & Photobiology

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Orthodontic tooth movement is based on mechanical forces inducing bone remodeling, and several methods have been proposed to increase tooth movement, including photobiomodulation. This study evaluated, in an animal model, the effects of photobiomodulation on SOFAT-a secreted osteoclastogenic factor of activated T cells and RANK-L during tooth movement. The results showed that tooth displacement, RANK-L and SOFAT levels were significantly greater compared to Control group. SOFAT may play an important role in bone remodeling during orthodontic movement, possibly increasing the osteoclast cells at the compression area and bone remodeling activity.

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Local delivery of EGF–liposome mediated bone modeling in orthodontic tooth movement by increasing RANKL expression

Cited by 37 publications

References 36 publications

Proteoliposomes in nanobiotechnology

Proteoliposomes in nanobiotechnology

Velocity of orthodontic active space closure with and without photobiomodulation therapy: a single-center, cluster randomized clinical trial

Effects of Photobiomodulation on SOFAT, A T‐cell‐derived Cytokine, May Explain Accelerated Orthodontic Tooth Movement

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