Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels

Çınar, Göksu; Özdemir, Ayşe; Hamsici, Seren; Günay, Gökhan; Dâna, Aykutlu; Tekinay, Ayşe B.; Güler, Mustafa O.

doi:10.1039/c6bm00656f

Cited by 56 publications

(32 citation statements)

References 47 publications

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“…Furthermore, the co-assemblies containing free N-termini on the surface of the nanofibers were able to bind the growth factors bone morphogenetic protein-2 (BMP-2) and transforming growth factor β1 (TGF-β), which are important in stem cell differentiation. Following similar oppositely charged peptide amphiphilic design principles, Guler and co-workers demonstrated supramolecular co-assembled nanofibers for drug delivery and tissue engineering applications 33,34…”

Section: Peptide Co-assembly Strategiesmentioning

confidence: 99%

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

2018

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Molecular self-assembly is a ubiquitous process in nature and central to bottom-up nanotechnology. In particular, the organization of peptide building blocks into ordered supramolecular structures has gained much interest due to the unique properties of the products, including biocompatibility, chemical and structural diversity, robustness and ease of large-scale synthesis. In addition, peptides, as short as dipeptides, contain all the molecular information needed to spontaneously form well-ordered structures at both the nano- and the micro-scale. Therefore, peptide supramolecular assembly has been effectively utilized to produce novel materials with tailored properties for various applications in the fields of material science, engineering, medicine, and biology. To further expand the conformational space of peptide assemblies in terms of structural and functional complexity, multicomponent (two or more) peptide supramolecular co-assembly has recently evolved as a promising extended approach, similar to the structural diversity of natural sequence-defined biopolymers (proteins) as well as of synthetic covalent co-polymers. The use of this methodology was recently demonstrated in various applications, such as nanostructure physical dimension control, the creation of non-canonical complex topologies, mechanical strength modulation, the design of light harvesting soft materials, fabrication of electrically conducting devices, induced fluorescence, enzymatic catalysis and tissue engineering. In light of these significant advancements in the field of peptide supramolecular co-assembly in the last few years, in this tutorial review, we provide an updated overview and future prospects of this emerging subject.

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Section: Peptide Co-assembly Strategiesmentioning

confidence: 99%

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

2018

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“…Nanofiber gels containing Dox to treat breast cancer locally (Fig. 4) were also formed by a different strategy [60]. Oppositely charged peptides that contained aliphatic alkyl tails self-assembled into gels.…”

Section: Pre-clinial Delivery Platforms Of Doxmentioning

confidence: 99%

Advances in Delivery Systems for Doxorubicin

Zhao

Woodle²,

Mixson

2018

J Nanomed Nanotechnol

179

104

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Doxorubicin is a widely used chemotherapy agent. Despite its utility, several adverse side effects, especially its irreversible cardiotoxicity and reversible nephrotoxicity, have prompted the development of liposomal carriers, many of which are FDA approved. Antitumor efficacies of approved liposome-Dox preparations can equal or exceed that of conventional doxorubicin. Because these liposomes carriers accumulate in solid tumor tissues via an enhanced permeation and retention (EPR) effect, these carriers have an improved safety profile. Nevertheless, a significant problem with the current drug delivery preparations of doxorubicin is a lack of efficacy toward tumors that exhibit multidrug resistance. In this review, we consider the development of drug delivery systems for doxorubicin, which improve the therapeutic window (efficacy and safety) and which address limitations of the current FDA-approved doxorubicin formulations.

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“…More recent examples combine two different peptides, A and B, that can self-associate (i.e., AA or BB) as well as co-assemble (i.e., AB). This approach can lead to biomaterials with new nanoscale structures 23 , hydrogelators 24 , gradated protein display 25 , scaffolding for anchorage-dependent cells 26 , drug delivery 27 , and insights into protein-misfolding diseases 28 .…”

mentioning

confidence: 99%

Charge guides pathway selection in β-sheet fibrillizing peptide co-assembly

et al. 2020

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Peptide co-assembly is attractive for creating biomaterials with new forms and functions. Emergence of these properties depends on the peptide content of the final assembled structure, which is difficult to predict in multicomponent systems. Here using experiments and simulations we show that charge governs content by affecting propensity for self- and co-association in binary CATCH(+/−) peptide systems. Equimolar mixtures of CATCH(2+/2−), CATCH(4+/4−), and CATCH(6+/6−) formed two-component β-sheets. Solid-state NMR suggested the cationic peptide predominated in the final assemblies. The cationic-to-anionic peptide ratio decreased with increasing charge. CATCH(2+) formed β-sheets when alone, whereas the other peptides remained unassembled. Fibrillization rate increased with peptide charge. The zwitterionic CATCH parent peptide, “Q11”, assembled slowly and only at decreased simulation temperature. These results demonstrate that increasing charge draws complementary peptides together faster, favoring co-assembly, while like-charged molecules repel. We foresee these insights enabling development of co-assembled peptide biomaterials with defined content and predictable properties.

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Local delivery of doxorubicin through supramolecular peptide amphiphile nanofiber gels

Cited by 56 publications

References 47 publications

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

Minimalistic peptide supramolecular co-assembly: expanding the conformational space for nanotechnology

Advances in Delivery Systems for Doxorubicin

Charge guides pathway selection in β-sheet fibrillizing peptide co-assembly

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